Clinical trials: Muscle Loss
Spinal Muscular Atrophy
Motor Unit Number Estimation (MUNE) in Adults With Spinal Muscular Atrophy (SMA)
The primary objective of this research protocol is to study and follow the course of motor neuron loss in individuals with spinal muscular atrophy (SMA) using the electrophysiological technique of motor unit number estimation…
- Trial name
- NCT04139343
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Disuse Atrophy, Aging
Immobilization and Protein Supplementation (IM-PRO)
In the present study, the effects of 5 days of lower limb immobilization with or without twice-daily protein supplementation on muscle mass and muscle fiber characteristics will be determined.
- Trial name
- IM-PRO (NCT01588808)
- Testing
- Immobilization
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia
Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O.
Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored.
- Trial name
- VD2O (NCT05624333)
- Testing
- Vegan diet (intervention), Omnivorous diet (control)
- Where
- Netherlands
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Sarcopenia
Koji Product Supplementation' s Study
The present project is to identify the effect of black soy beans Koji product supplementation on nutrients absorption and anti-aging effect in elderly.
- Trial name
- KPS (NCT04951843)
- Testing
- Black soybean koji product
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sarcopenia, Frailty
Effectiveness of Individual Physical Activity Programs to Prevent Sarcopenia and Frailty Among Older Adults
Sarcopenia and frailty could be prevented and rehabilitated through individual physical activities in the form of combined exercise that could be practiced at home in daily life.
- Trial name
- NCT06149871
- Testing
- Physical activity
- Where
- Thailand
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand
Sarcopenia, Physical Fitness
Swedish Physical Activity and Fitness Longitudinal Study
Aging means loss of strength, which can affect the ability to lead an active life and be independent. Physical activity can counteract the loss of strength to some extent, but individual differences are large and the mechanisms…
- Conditions
- Sarcopenia, Physical Fitness, Muscle Strength, Dynapenia
- Trial name
- SPAF (NCT06496204)
- Where
- Sweden
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Muscular Atrophy, Spinal
Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants
The study is a randomized, single oral dose, crossover study in up to three parts to investigate the relative bioavailability and bioequivalence of two different formulations of risdiplam 5 mg (dispersible tablets) versus the…
- Trial name
- NCT04718181
- Testing
- risdiplam, omeprazole
- Where
- 4 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Physical Disability
Multi-ingredient Nutrition Supplement in Older Adults
The aims of the present study are: i. To conduct a population study of body composition, muscle function and ability to undertake activities of daily living in elderly Irish individuals ii.
- Trial name
- NCT02001831
- Testing
- Supplement
- Where
- Ireland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Sarcopenia
Muscle Ageing Sarcopenia Study Lifecourse (MASS Lifecourse)
Sarcopenia is the loss of muscle mass and function with age. It has been recognised as an important health problem because it is common in older adults and associated with decline in physical function as well as a reduced quality…
- Trial name
- MASS_LC (NCT04239495)
- Testing
- Observational study: range of clinical and lifestyle factors
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Sarcopenia, Frailty
Prevalence of Two Major Geriatric Syndromes: Sarcopenia and Frailty
Sarcopenia and frailty are two major syndromes in older adults. They are shown to be associated with low levels of functioning and higher rates of morbidity and mortality.
- Conditions
- Sarcopenia, Frailty, Frailty Syndrome
- Trial name
- NCT04146844
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Goztepe Training and Research Hospital
Sarcopenia
Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function
The primary aim of the current research project is to explore whether nutritional supplementation and resistance training might be combined to produce synergistic effects in the prevention of muscle loss during aging.
- Trial name
- NCT03907592
- Testing
- L-carnitine supplementation, Leucine supplementation, Resistance training
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Sarcopenia, Dynapenia
Omega-3 Supplementation and Resistance Training
The purpose of this project is to evaluate whether omega-3 fatty acid supplementation (combined eicosapentaenoic acid and docosahexaenoic acid [EPA/DHA] supplement) augments the effects of a 12-week resistance training program in…
- Conditions
- Sarcopenia, Dynapenia, Inflammation
- Trial name
- NCT02617511
- Testing
- Omega-3 Supplementation
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Spinal and Bulbar Muscular Atrophy, Healthy Subjects
High Intensity Training in Patients With Spinal and Bulbar Muscular Atrophy
We want investigate if high intensity training can increase daily functionality without causing muscle damage in patients Spinal and Bulbar Muscular Atrophy .
- Trial name
- HIT in Kennedy (NCT02156141)
- Testing
- Supervised high intensity training, Optional training, Control period
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karen Brorup Heje Pedersen
Healthy Male Volunteers Over 65
Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults
Occupying ~45-55% of body mass, skeletal muscle is the largest organ of the body and plays a pivotal role in locomotion, structural support and whole-body metabolic health.
- Trial name
- NCT06971822
- Testing
- Protein Supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenic Obesity
Sarcopenic Obesity Among Community Dwelling Elderly
Sarcopenic obesity (SO) is a geriatric syndrome, characterized by reduced muscle mass and function, and increase in body fat. It is classified as a new category of obesity in elderly.
- Trial name
- NCT04140864
- Where
- Malaysia
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Muscle Atrophy, Hypodynamia
Safety Study of HPP593 in Subjects During and After Limb Immobilization
This is a safety and tolerability study investigating the effect of HPP593 in healthy volunteers during and after limb immobilization.
- Trial name
- NCT01524406
- Testing
- HPP593
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- High Point Pharmaceuticals, LLC.
Sarcopenia, Muscle Weakness
Functional Changes and Power Training in Older Women.
Extending quality of life and attenuating functional decline is paramount in older adults. This study investigates the effects of low-intensity power-training in older women and its effects on functional outcomes.
- Trial name
- F-POW (NCT02530723)
- Testing
- power training
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sarcopenia, Frailty
Sarcopenia Prevention With a Targeted Exercise and Protein Supplementation Program
Physical inactivity and protein malnutrition have been implicated to be key and modifiable causes of enhanced muscle mass loss among seniors.
- Conditions
- Sarcopenia, Frailty, Malnutrition; Protein, Fall
- Trial name
- STRONG (NCT03417531)
- Testing
- Protein Supplement, Protein-free Supplement, Active Exercise
- Where
- 2 sites in Switzerland
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sarcopenia
Effect of Ishige Okamurae Extract on Musculoskeletal Biomarkers in Adults With Relative Sarcopenia
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Ishige Okamurae extracts on muscle strength, muscle mass, and muscle function in adults with relative sarcopenia for 12…
- Trial name
- NCT04617951
- Testing
- Ishige Okamurae extracts group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Sarcopenia, Osteoporosis
Ibuprofen Supplementation After Resistance Training and Its Effects on Bone in Older Women
Inflammation increases with aging and is implicated in the reduction of bone mass, muscle mass, and strength. Resistance training is safe and effective for increasing muscle mass and strength in older adults,however resistance…
- Trial name
- NCT01886196
- Testing
- Non-steroidal anti-inflammatory drug (Ibuprofen), Resistance exercise, Flexibility training
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan