Clinical trials: Muscle Loss
Hypertrophy, Exercise Training
Resistance Training, Detraining, and Retraining Study 2024 (TraDeRe2024)
The goals of our research project are to identify factors explaining inter-individual variation in responses to resistance training (RT) and the baseline determinants underlying an individual's sensitivity to respond to RT.
- Conditions
- Hypertrophy, Exercise Training, Skeletal Muscle Atrophy, Healthy
- Trial name
- TraDeRe (NCT06573086)
- Testing
- Resistance Training
- Where
- Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Public Health, Sarcopenia
Appendicular Skeletal Muscle Mass Study
There is a lot of discussion concerning the normal cut-off points of skeletal mass among different populations worldwide. Genetic and environmental differences most probably lead to different measurements.
- Trial name
- SmmS (NCT04584944)
- Testing
- Dual energy X-ray absorptiometry
- Where
- Greece
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Henry Dunant Hospital Center
Sarcopenia
Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally
The overall aim of the TEMPUS-FUGIT study is to assess gut microbiota composition in older persons without sarcopenia and to determine the relationship with and between intestinal and systemic inflammation and with…
- Trial name
- TEMPUS-FUGIT (NCT05008770)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sarcopenia
Lysosomal Movement and Anabolic Resistance
Age-associated loss of muscle mass, termed sarcopenia, is strongly associated with functional impairment and physical disability in the elderly.
- Trial name
- NCT03032757
- Testing
- Essential amino acids
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Sarcopenia
Understanding Loss of Muscle Mass and Function
Sarcopenia is a loss of muscle mass and function that develops during aging. But sarcopenia is also observed in several other conditions: chronic diseases, cancers, viral infections, renal / respiratory insufficiency, immobility…
- Trial name
- SAMANTHA (NCT04004039)
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sarcopenia
Bioindicators Associated With Sarcopenia Before and After Intensive Lifestyle Intervention
The goal of this clinical trial is to explore whether the bioindicators of body composition, nutrition-related indicators (lymphocytes, albumin), lipids, and thyroid hormones are associated with sarcopenia and the changes in…
- Trial name
- NCT06128577
- Testing
- 3-month intensive intervention
- Where
- China
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Lijun Yang
Frail Elderly Syndrome, Sarcopenia
TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults
To explore the effect of "Lactobacillus plantarum TWK10 (hereinafter referred to as TWK10)" produced by synbiotech Biotechnology Co., Ltd. on alleviating and improving the aging and debilitating diseases of the elderly.
- Trial name
- NCT04893746
- Testing
- Lactobacillus plantarum TWK10-L, Maltodextrin, Lactobacillus plantarum TWK10-H
- Where
- Taiwan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Sarcopenia
Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle
This study has two protocols the aims of which are: 1. To identify age-related effects of AA on incretin secretion and whether and to what extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in…
- Trial name
- Incretin (NCT02370745)
- Testing
- GLP-1, Insulin Actrapid, Oral amino acids
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia, Spinal Disease
Spinal Sarcopenia Cohort Study (SarcoSpine)
Sarcopenia on lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there are few studies on the precise concept and diagnostic criteria for spinal sarcopenia.
- Trial name
- SarcoSpine (NCT03962530)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Sarcopenia
Effect of Silkworms (Bombyx Mori L.) Pupae Extracts on Musculoskeletal Biomarkers in Adults
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of silkworms (Bombyx mori L.) pupae extracts on muscle strength, muscle mass, and muscle function in adults with relative…
- Trial name
- NCT04994054
- Testing
- silkworms (Bombyx mori L.) pupae extracts group
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Quadriceps Tendon Rupture, Quadriceps Strained Tendon
The Effect of the Reverse Nordic Curl Exercise on Quadriceps Femoris Muscles Injury Rate Among Soccer Players
The reverse Nordic curl is a body-weight exercise which mainly works the quadriceps and hip flexors. It has a large eccentric component, meaning the muscles are working whilst lengthening.
- Conditions
- Quadriceps Tendon Rupture, Quadriceps Strained Tendon, Quadriceps Muscle Atrophy
- Trial name
- NCT04674072
- Testing
- Reverse Nordic curl exercise, Usual warm up
- Where
- Saudi Arabia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
Sarcopenia, Inflammation
Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly
Sarcopenia, which refers to the progressive loss of skeletal muscle mass and strength, shares many characteristics with other disease states typically associated with risks of falling and fracture, including osteoporosis…
- Conditions
- Sarcopenia, Inflammation, Aging
- Trial name
- NCT04985877
- Testing
- Yakult 300 LIGHT Fermented Milk
- Where
- 3 sites in Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics
Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly
Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge…
- Conditions
- Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics, Sarcopenia
- Trial name
- NCT01640145
- Testing
- Protein, Exercise
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Sarcopenia
Clinical Trial of Astaxanthin Formulation With Exercise in Sarcopenia Elderly
The primary objective of this trial is to evaluate the effect of oral administration of an Astaxanthin formulation compared to placebo after one month alone and after an additional 3 months of exercise training on mitochondrial…
- Trial name
- NCT03368872
- Testing
- Astaxanthin formulation, Exercise training
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Astavita, Inc.
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Sarcopenia
Muscle Capillarization and Sarcopenia
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders.
- Trial name
- NCT03984994
- Testing
- Aerobic exercise training, Strength training
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Muscle Mass, Muscle Strength
Multicomponent vs Pilates on Mass, Strength, and Physical Performance in Older Adults
Introduction: The aging process can result in several physiological changes, such as the loss of muscle mass, muscle strength, and physical performance, collectively defined as sarcopenia.
- Conditions
- Muscle Mass, Muscle Strength, Physical Performance
- Trial name
- versus (NCT06719505)
- Testing
- ME, PE
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do Norte do Parana
Sarcopenia, Functional Decline
Impact of Acute Hospitalisation and Resistance Training on Muscle Architecture and Physical Performance in Older Adults
Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline.
- Conditions
- Sarcopenia, Functional Decline, Muscle Architecture, Gait Speed
- Trial name
- NCT05798169
- Testing
- Resistance training
- Where
- Denmark
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Military Operational Stress Reaction, Malnutrition (Calorie)
Physiological Response to Protein and Energy-enhanced Food Products During Winter Military Training
Soldiers commonly lose muscle mass during training and combat operations that produce large energy deficits (i.e., calories burned > calories consumed).
- Conditions
- Military Operational Stress Reaction, Malnutrition (Calorie), Weight Loss, Muscle Wasting
- Trial name
- NCT05210205
- Testing
- EAA, Energy Dense, Control
- Where
- Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine