Clinical trials: Muscle Loss
Weakness, Muscle
Bed Rest and Muscle Strength in ICU: Interest in the Early Association of NEMS With Cyclo-ergometer Mobilization
Muscles atrophy and weakness are common in intensive care units, their origin is multifactorial. Passive then active mobilization with cyclo-ergometer have shown to improve functional abilities and limit muscle weakness among…
- Trial name
- AFMPR (NCT03987997)
- Testing
- Early association of electrical muscle stimulation with cyclo-ergometer
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Sarcopenia, Gestational Diabetes Mellitus (GDM)
Sarcopenia in Gestational Diabetes
Sarcopenia is a syndrome characterized by loss of skeletal muscle mass and strength, and physical performance deterioration. Prevalence of sarcopenia in elderly people is remarkably high (prevalence of about 25% in 60+ years…
- Conditions
- Sarcopenia, Gestational Diabetes Mellitus (GDM), Pregnancy Complications, Adverse Maternal and Neonatal Outcomes
- Trial name
- SiGnal-D (NCT06876090)
- Testing
- Sarcopenia tests (for muscle mass, muscle function, physical performance), Oral Glucose Tolerance Test, Montreal Cognitive Assessment
- Where
- 3 sites in Austria, Italy
- Volunteers
- 200 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
Sarcopenia
Resistance Exercise or Vibration With HMB for Sarcopenia
Sarcopenia is a geriatric syndrome characterised by the progressive loss of skeletal muscle mass and function with a risk of adverse outcomes. In Hong Kong, the prevalence of sarcopenia in community-dwelling older people was 9%.
- Trial name
- NCT04028206
- Testing
- Hydroxymethylbutyrate, Low-magnitude High Frequency Vibration (LMHFV), Elastic-band Exercise
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- Chinese University of Hong Kong
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sarcopenia
Koji Product Supplementation' s Study
The present project is to identify the effect of black soy beans Koji product supplementation on nutrients absorption and anti-aging effect in elderly.
- Trial name
- KPS (NCT04951843)
- Testing
- Black soybean koji product
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Muscular Atrophy, Spinal
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants
Multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of Risdiplam in adult and pediatric participants with Type 2 and Type 3 SMA.
- Trial name
- SUNFISH (NCT02908685)
- Testing
- Risdiplam
- Where
- 45 sites in United States, Belgium and 14 more
- Volunteers
- 231 people
- Sponsor
- Hoffmann-La Roche
Vitamin D Deficiency, Sarcopenia
Impact of Vitamin D on 25-hydroxyvitamin D Levels and Physical Function
This one-year study will test the hypothesis that supplementation with vitamin D will improve lower extremity muscle performance in older men and women with vitamin D insufficiency.
- Trial name
- NCT02293187
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tufts University
Hip Osteoarthritis, Osteoarthritis, Hip
Gluteal Sling Release on Gluteal Dysfunction After in Primary Total Hip Arthroplasty
This study investigates the effects of gluteal sling release during total hip arthroplasty (THA) on gluteal muscle function and hip joint performance.
- Conditions
- Hip Osteoarthritis, Osteoarthritis, Hip, Gluteus Maximus Muscle Atrophy, Muscle Weakness Condition
- Trial name
- NCT06850155
- Testing
- Sling release, Sling release and repair
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Ankara City Hospital Bilkent
Frailty, Sarcopenia
Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients
After obtaining ethical approval, 42 patients with American Society of Anesthesiologists (ASA) scores I-III who were scheduled for surgery under general anesthesia were included in our prospective study.
- Trial name
- NCT06889714
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Muscle Atrophy, Insulin Resistance
Role of Metformin on Muscle Health of Older Adults
Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the…
- Trial name
- NCT03107884
- Testing
- Metformin (Bed Rest), Metformin (2 week run-in only)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
CAPTURE ALS is a long-term data and biorepository platform that will facilitate future ALS research. CAPTURE ALS will provide the standardized systems and tools necessary to collect, store, and analyze vast amounts of multimodal…
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Degeneration
- Trial name
- CAPTURE ALS (NCT05204017)
- Where
- 4 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity, Cardiovascular Disease
IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial
As individuals age, their physical activity decreases and sedentary time increases. Even small changes in these two behaviors can greatly decrease risks for several major health problems, including cardiovascular disease…
- Conditions
- Obesity, Cardiovascular Disease, Cancer, Diabetes
- Trial name
- IMPACT (NCT01869348)
- Testing
- Monitor intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Immune Senescence, Sarcopenia
Effects of PS-IPC Supplementation on Muscle Mass and Functional Outcomes in Older Adults
Sarcopenia, the age-associated loss of skeletal muscle mass and strength, is a frequent precursor to functional impairment, disability, falls, and loss of independence in the elderly.
- Trial name
- PS-IPC (NCT00926250)
- Testing
- Oral PS-IPC supplement
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Neuromuscular Diseases, Sarcopenia
Soft-robotic Glove Support of High-demand Tasks
The hand is important to perform activities of daily living (ADL). However, many people experience a loss of hand function as result of a traumatic brain injury, spinal cord injury, stroke or orthopedic problems, or due to…
- Trial name
- NCT05318638
- Testing
- Soft robotic glove
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Roessingh Research and Development
Kidney Diseases, Muscle Loss
Protein and Exercise Training in Chronic KIDNEY Disease
When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent.
- Trial name
- PET KIDNEY (NCT05482243)
- Testing
- Whey protein
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia
Effects of Dietary Supplements on Sarcopenic Elders
Sarcopenia is defined as a syndrome characterized by decline of skeletal muscle mass and strength or an alteration in physical function.
- Trial name
- NCT03860194
- Testing
- Protison with High Protein 51(Original Flavor)
- Where
- Taiwan
- Volunteers
- 85 people
- Sponsor
- Far Eastern Memorial Hospital
Elderly, Sarcopenia
Human Muscle Gene Expression Profiles in Young and Old Men
To reach the goals of living longer in better medical conditions, many countries reach the same conclusion: new strategies have to be developed to avoid, or at least limit, the effects of age; this requires a better knowledge of…
- Trial name
- CERA (NCT00725166)
- Testing
- Skeletal muscle aging
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aging, Healthy Aging
Eating Habits and Lifestyle Profile of an Italian Aging Cohort
Aging is characterized by low-grade inflammatory state, supported by impairment oxidative balance and endocrine changes, leading to changes in: body composition, such as decrease in lean body mass and increase in adipose tissue…
- Conditions
- Aging, Healthy Aging, Life Style, Eating Habit
- Trial name
- NCT04401930
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Knee Osteoarthritis
Project Arthritis Recovering Quality of Life Through Education 70+
Introduction: Quadriceps weakness was previously associated with functional impairment of osteoarthritis (OA). Evidence also suggests that muscle strength may prevent the progression of existing OA.
- Trial name
- PARQVE (NCT04058002)
- Testing
- Multiprofessional treatment and Educational Program Associated (EPA+C+BCAA) with supplementation of creatine and BCAA., Multiprofessional treatment and Educational Program Associated (EPA+C) with supplementation of creatine only.
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
Frailty, Frailty/Sarcopenia
Clinical and Functional Effectiveness Assessment of Personalized Management Programs for Patients With Frailty
All participants underwent comprehensive geriatric assessment (CGA) and cardiopulmonary exercise testing (CPET). A personalized management program was developed for each patient, including recommendations on physical exercise…
- Trial name
- NCT07623694
- Testing
- Geriatric rehabilitation program based on CGA and CPET
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- Pirogov Russian National Research Medical University