Clinical trials: Muscle Protein Synthesis
Muscle, Skeletal, High-Intensity Interval Training
Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT
High intensity interval training (HIIT) has recently emerged as a time efficient alternative to conventional endurance exercise, conferring similar or superior benefits in terms of metabolic and performance adaptations in both…
- Conditions
- Muscle, Skeletal, High-Intensity Interval Training, Exercise
- Trial name
- NCT03570424
- Testing
- Nutrient support to HIIT
- Where
- Ireland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Overweight and Obesity
The Effect of Very Low Calorie Diet With and Without Exercise on Muscle Synthesis in Middle-aged Overweight Male.
The aims of this project are: to investigate the impact of VLCD on control of muscle protein synthesis, muscle structure and function, cardiac function (ejection fraction), vascular function (blood flow and capillary function)…
- Trial name
- VLCDex (NCT03116256)
- Testing
- Very low calorie diet (VLCD), High intensity interval training (HIIT), Resistance exercise training (RET)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Motor Disorder, Reliability and Validity
Turkish Translation , Validity and Reliability of the Hypertonia Assessment Tool in Children With Motor Disorders
Translating batteries with good psychometric properties into Turkish will increase the number of assessment batteries we can use in our language for clinical and academic studies.
- Conditions
- Motor Disorder, Reliability and Validity, Hypertonia
- Trial name
- NCT07267442
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kastamonu University
Muscle Wasting
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years).
- Trial name
- SPRINT (NCT07062562)
- Testing
- NMES, Protein bolus (20g), Standard nutrition
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Muscle Protein Synthesis
Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates
Rationale: Protein ingestion stimulates muscle protein synthesis and augments the muscle protein synthetic response to a single exercise session.
- Trial name
- Blend (NCT05386771)
- Testing
- Whey/collagen protein blend, Resistance exercise
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
The Effect of Menstrual Cycle Phase and Protein Dose on Muscle Protein Synthesis
Adaptation to resistance exercise requires maximal rates of muscle protein synthesis, which can be achieved with post-exercise ingestion of ~20g of protein.
- Trial name
- NCT05178732
- Testing
- Dose of protein, Menstrual cycle phase
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Interventional
Influence of Leucine Enriched Amino Acids on Myofibrillar and Collagen Protein Synthesis
The primary objective will be to determine the effect of leucine-enriched essential amino acids (LEAA) compared to carbohydrate placebo on dietary incorporation of [D5] Phenylalanine \& [D5] Glycine into the three skeletal muscle…
- Trial name
- NCT05554653
- Testing
- Leucine enriched amino acids
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Daniel Moore
Muscle Weakness, Critical Illness
Development of the Italian Version of the ICU Mobility Scale (IMS). Cross-cultural Adaptation, Italian Translation, and Validation Study.
Early mobilisation of the patient admitted to intensive care units (ICUs) is essential to prevent Intensive Care Unit Acquired Weakness (ICUAW).
- Conditions
- Muscle Weakness, Critical Illness, Critical Illness Recovery, Acquired Weakness
- Trial name
- NCT07195942
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Amino Acids, Dietary Protein
Influence of Sex and Training on de Novo Muscle Protein Synthesis
Acute exercise increases the incorporation of dietary amino acids into de novo myofibrillar proteins after a single meal in controlled laboratory studies in males.
- Conditions
- Amino Acids, Dietary Protein, Sex, Resistance Exercise
- Trial name
- TUT (NCT04887883)
- Testing
- Resistance exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Myotonic Dystrophy 1
Myotonic Dystrophy Type 1 and Resistance Exercise
The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1.
- Trial name
- STYRK DM1 (NCT05036447)
- Testing
- Moderate-Heavy Resistance Exercise
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Muscle Protein Synthesis
Impact of Nitrate Ingestion on Protein Synthesis
A diet rich in leafy green vegetables has been shown to reduce the risk of developing chronic metabolic disease. The health benefits from these particular vegetables may be attributed to their high nitrate content.
- Trial name
- PRO-Nitrate (NCT01473576)
- Testing
- Nitrate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Synthesis
Protein Blends (Soy, Whey and Casein) for Muscle Synthesis
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow).
- Trial name
- NCT01358305
- Testing
- Protein Blend
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Healthy
Amino Acid Profile and Muscle Protein Synthetic Response to Consuming Meat or Plant-based Alternatives
The purpose of the study is to quantify and compare the serum amino acid profile, and muscle protein synthesis rates, in response to consuming isonitrogenous amounts of ground meat (beef and pork) or plant-based alternatives…
- Trial name
- NCT04784806
- Testing
- Ground beef, Ground pork, Tofu
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Muscle Weakness, Critical Illness
Translation and Validation of the Intensive Care Unit Mobility Scale (IMS)
Intensive care unit acquired weakness (ICUAW) is a common issue in critically ill patients. Early mobilization can reduce the occurrence of ICUAW. This requires a standardized procedure based on validated scales.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication, Early Mobilization
- Trial name
- TAVIMS (NCT05591950)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Exercise Recovery
Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates
The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes.
- Trial name
- NCT00975390
- Testing
- Carbohydrate, Carbohydrate and protein ingestion, Carbohydrate and caffeine ingestion
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Loss
Muscle Protein Synthesis in Dialysis Patients
The most severe form of chronic renal failure is end-stage-renal-disease with maintenance hemodialysis (MHD) as the most common treatment strategy.
- Trial name
- NCT03478722
- Testing
- Protein Meal, Stable Isotope Amino Acid Infusion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Kidney Diseases, Muscle Loss
Protein and Exercise Training in Chronic KIDNEY Disease
When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent.
- Trial name
- PET KIDNEY (NCT05482243)
- Testing
- Whey protein
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response
Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response…
- Trial name
- BPM (NCT04894747)
- Testing
- Bolus ingestion of protein
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy Elderly Muscle, Anabolically Resistant Elderly Muscle
Protein Nutrition for Muscle Hypertrophy in Older Adults
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.
- Trial name
- NCT02315391
- Testing
- isolated whey protein, micellar whey protein, glycine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)