Clinical trials: Muscle Protein Synthesis
Chronic Obstructive Pulmonary Disease, Muscle Wasting
Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in Chronic Obstructive Pulmonary Disease (COPD): Aim 2
Loss of muscle protein is generally a central component of weight loss in Chronic Obstructive Pulmonary Disease (COPD) patients.
- Trial name
- NCT01624792
- Testing
- Olive oil, Fish oil
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Muscle Synthesis
Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults
During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility.
- Trial name
- NCT01847261
- Testing
- Soy Dairy Protein Blend, Positive Control (Dairy Whey Protein)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Plantar Fasciitis
Plantar Heel Pain: Multisegment Foot Motion and Muscle Function, FFI Translation, and Evaluation of Treatments
Plantar fasciitis (PF) is a prevalent musculoskeletal condition of plantar heel pain (PHP) that leads to pain, functional limitations, and reduced quality of life, especially among active adults aged 25 to 65.
- Trial name
- NCT03161314
- Testing
- Strengthening exercises, Stretching exercises
- Where
- 2 sites in Thailand
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypertrophy
Muscle Protein Synthesis After Whole Egg vs. Egg White Consumption
In crossover trials, ten (N=10) young men (18-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise.
- Trial name
- NCT03117127
- Testing
- Resistance Exercise, Whole Eggs, Egg Whites
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Older Adults Without Any Specific Clinical Condition
Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults
Healthy older adults and those who have acute and chronic conditions suffer from reduced protein intake and are at risk of developing both chronic and acute sarcopenia.
- Trial name
- NCT07754760
- Testing
- Essential amino acid supplement
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Hunger, Satiety Response
Effects of Hydrolysed Porcine Proteins on Muscle Protein Synthesis and Appetite
The purpose of the study is to obtain a better understanding of how hydrolysed porcine proteins affect the human metabolism, including the effects on muscle protein synthesis, appetite and secretion of gastrointestinal hormones.
- Conditions
- Hunger, Satiety Response, Protein Synthesis
- Trial name
- SEPA (NCT02477410)
- Testing
- Hydrolysed porcine protein from blood, Hydrolysed porcine protein from muscle, Hydrolysed whey protein
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Phenylketonuria, PKU
Moderate Intensity Exercise and Phenylketonuria
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout…
- Trial name
- NCT01904708
- Testing
- Acute Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Healthy
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
- Trial name
- NCT03571425
- Testing
- Oral Protein, Enteral Protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Mitochondrial Biogenesis
Time-course of Mitochondrial Biogenic Gene and Protein Expression in Exercised Human Skeletal Muscle
This study examines the impact of exercise intensity on the 12-hour time-course of mitochondrial biogenic gene and protein expression in human skeletal muscle.
- Trial name
- NCT03975777
- Testing
- LO, HI
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brendon Gurd, PhD
Nutritional Intervention Using Protein Rich Whole Food Sources
Investigating the Consumption of Different Protein Rich Whole Food Sources on Muscle Growth in Trained Males and Females
Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source.
- Trial name
- FFT (NCT04794153)
- Testing
- whole food sources
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Musculoskeletal Pain, Autonomy
Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian
The cross-cultural adaptation will be performed according to the internationally recommended methodology, using the following guidelines: translation, back-translation; revision by a committee, questionnaire diffusion and data…
- Conditions
- Musculoskeletal Pain, Autonomy, Healthy, Upper Limb Injury
- Trial name
- NCT06685094
- Where
- Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Time Restricted Feeding
Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Recent research shows that timing of nutritional intake and daily periods of fasting may have important health effects. In humans, limiting daily food intake to a narrow window (typically ~8 hours) can bring about some beneficial…
- Trial name
- NCT05420181
- Testing
- Short 10hr fast, Long 16h fast
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Omega-3 Fatty Acids and Muscle Protein Synthesis
The purpose of this study is to determine whether omega-3 fatty acid supplementation influences muscle protein synthesis rates in young and older adults.
- Trial name
- NCT00794079
- Testing
- omega-3 fatty acids, corn oil
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Protein, Diet
A Meal-based Comparison of Protein Quality, Complementary Proteins and Muscle Anabolism
To highlight the importance of protein quality rather than the total protein content of a meal, the investigators will demonstrate that unlike high quality proteins, a single meal containing 30 g of an incomplete protein source…
- Conditions
- Protein, Diet, Skeletal Muscle
- Trial name
- MAPP (NCT03816579)
- Testing
- PRO-A, PRO-B, PRO-C
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Muscle Protein Synthetic Response to Protein, Muscle Protein Synthesis
Diet Synergy in Muscle Protein Synthesis
In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise.
- Conditions
- Muscle Protein Synthetic Response to Protein, Muscle Protein Synthesis, Muscle Health, Protein Metabolism
- Trial name
- POTATO (NCT07367854)
- Testing
- Resistance Exercise, Potato and Beef, Bread and Beef
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Amino Acids, Dietary Protein
Influence of Sex and Training on de Novo Muscle Protein Synthesis
Acute exercise increases the incorporation of dietary amino acids into de novo myofibrillar proteins after a single meal in controlled laboratory studies in males.
- Conditions
- Amino Acids, Dietary Protein, Sex, Resistance Exercise
- Trial name
- TUT (NCT04887883)
- Testing
- Resistance exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Adult Participants
Yeast Protein for Muscle Mass
Protein supplementation is said to be one of the cost-efficient and practical strategies to meet protein needs for growth and exercise, and can help maximize muscle gain from resistance exercise.
- Trial name
- NCT07561619
- Testing
- Yeast Protein, Resistance Training Exercises, Whey Protein
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sarcopenia
Protein Synthesis in Midthigh Muscles PET/CT
The purpose of this study is to test a new imaging technique to help scientists study sarcopenia, the process by which muscle becomes weaker with age.
- Trial name
- NCT01008839
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ketosis, Muscle Protein Synthesis
Exogenous Ketosis and Muscle Protein Synthesis During Exercise Recovery
An acute bout of resistance exercise stimulates muscle protein synthesis (MPS) rates for up to 24-48 hours, supporting muscle growth and repair.
- Conditions
- Ketosis, Muscle Protein Synthesis, Dietary Proteins, Resistance Exercise
- Trial name
- NCT06769100
- Testing
- Ketone Monoester (KET), Ketone Monoester + Whey Protein (KET+PRO), Whey Protein (PRO)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McGill University