Clinical trials: Muscle Protein Synthesis
Dairy Products, Muscle Protein Synthesis
The Effect of Whole Milk to Improve Muscle Health in Older Women
Muscle and strength begin to noticeably decline around 50 years of age, increasing an individual's risk for disease and disability.
- Conditions
- Dairy Products, Muscle Protein Synthesis, Aging, Physical Activity
- Trial name
- NCT04981652
- Testing
- Whole Milk, Skim Milk, Almond Beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Effect of Food Supplement
Effect of Insect-derived Protein Supplements on Protein Synthesis and mTORC1 Activation
The purpose of this study is to determine the ability of insect-derived protein supplements (IPC80 and Whole Buffalo Powder Ynsect®) to activate the mTORC1 pathway and protein synthesis in muscle cells.
- Trial name
- NCT05457218
- Testing
- Whey protein, IPC80, Whole Buffalo Powder
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Old Age; Debility, Muscle Weakness
Probiotic-Muscle Study
This study will examine the effect of probiotic supplementation (Bacillus coagulans) on muscle protein synthesis in older adults in response to a plant-based diet.
- Conditions
- Old Age; Debility, Muscle Weakness, Protein Deregulation, Protein Deposition
- Trial name
- NCT04297111
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Sarcopenia
Protein Synthesis in Midthigh Muscles PET/CT
The purpose of this study is to test a new imaging technique to help scientists study sarcopenia, the process by which muscle becomes weaker with age.
- Trial name
- NCT01008839
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aging
Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
Using stable isotope methodology, investigators will determine the postabsorptive and postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: <30 kg/m2) immediately after an acute bout of resistance…
- Trial name
- NCT02918981
- Testing
- Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Sedentary Lifestyle
Influence of Sedentary Time on Skeletal Muscle Protein Metabolism
This study will investigate the influence of increased sedentary time on long-term measures of muscle protein synthesis and metabolic health.
- Trial name
- NCT02624011
- Testing
- 7 days of habitual physical activity followed by 7 days of reduced physical activity
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscle Protein Synthesis
Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women
This study investigates whether a protein-nutrition beverage can increase muscle protein synthesis to a similar magnitude as a control beverage.
- Trial name
- NCT02282566
- Testing
- Protein-nutrition beverage
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Muscle Protein Synthesis
Effects of Ingesting Multiple Boluses of Collagen on Muscle & Skin Connective Protein Synthesis in Vivo in Humans
Rationale: Collagen protein is the central structural component of extracellular connective tissues within skeletal muscle, bone, cartilage and skin.
- Trial name
- CODIAK (NCT06435637)
- Testing
- Collagen protein, Resistance exercise
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
- Trial name
- NCT03571425
- Testing
- Oral Protein, Enteral Protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Sarcopenia
Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O.
Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored.
- Trial name
- VD2O (NCT05624333)
- Testing
- Vegan diet (intervention), Omnivorous diet (control)
- Where
- Netherlands
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Ketosis, Regulation of Muscle Protein Synthesis
Ketones and Muscle Protein Synthesis
Ketones are natural substances normally produced by the body during prolonged fasting and starvation, or in response to a "ketogenic" diet to be used as fuel by the brain and muscles.
- Trial name
- NCT04565444
- Testing
- Ketone, Ketone + Protein, Protein
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McGill University
Muscle Function
Female Muscle Enhancement
Participating in regular physical activity has been shown to reduce the risk of developing some diseases and disabilities that can occur with ageing.
- Trial name
- FemME (NCT05397418)
- Testing
- Supervised resistance exercise program, Unsupervised resistance exercise program
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Synthesis
Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults
During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility.
- Trial name
- NCT01847261
- Testing
- Soy Dairy Protein Blend, Positive Control (Dairy Whey Protein)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Obesity
Resistance Exercise and Muscle Protein Synthesis in Obese Adults
Obesity has numerous comorbidities that are associated with exceedingly high healthcare costs. In addition to well- characterized impairments in lipid and glucose metabolism, obesity is associated with altered protein metabolism.
- Trial name
- NCT03411681
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Parkinson Disease
Essential Amino Acids and Parkinsons Disease
Parkinson's disease is a neuromuscular disease that is relatively common in elderly that has many potentials symptoms, including a variety of physical features that together reduce quality of life.
- Trial name
- EAAPD (NCT06604065)
- Testing
- AMS2434 (amino acids)
- Sponsor
- University of Arkansas
Aging
The Effects of Whey vs. Collagen on MPS
With aging there is a natural loss of muscle mass and strength called sarcopenia, which increases the risk of falls and metabolic disease (i.e. Type II diabetes) and decreases the ability to perform activities of daily living.
- Trial name
- NCT03281434
- Testing
- Collagen peptide, Whey protein isolate
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hypertrophy
Muscle Protein Synthesis After Whole Egg vs. Egg White Consumption
In crossover trials, ten (N=10) young men (18-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise.
- Trial name
- NCT03117127
- Testing
- Resistance Exercise, Whole Eggs, Egg Whites
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy
Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis
The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
- Trial name
- 2d-BR (NCT03877822)
- Testing
- Habitual activity, Bed rest
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Exeter
Rotator Cuff Tear
Load-induced Changes in Glenohumeral Translation in Patients With Rotator Cuff Tear
The study is to investigate the dose-response relationship between load-induced muscle activation (liMA) and load-induced glenohumeral translation (liTr) in patients with rotator cuff tears and asymptomatic control subjects.
- Trial name
- LiTrans (NCT04819724)
- Testing
- 3D motion analysis, isometric shoulder strength by dynamometer, fluoroscopic images of each shoulder
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland