Clinical trials: Muscle Relaxant
Unilateral Knee Arthroplasty
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces…
- Trial name
- IVAM (NCT02449369)
- Testing
- Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Muscle Relaxation, Sex
Sex-related Differences in the Response to the Muscle Relaxant Drug Mivacurium
Muscle relaxants are drugs providing muscle relaxation during surgical treatment. Previous studies have shown that males and females respond differently to this kind of drug.
- Trial name
- NCT01906528
- Testing
- Mivacurium
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anesthesia, Bronchoscopy
Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for Bronchoscopy
The goal of this clinical trial is to evaluate whether mivacurium chloride and succinylcholine can provide effective and safe muscle relaxation in adult patients aged 18-60 years undergoing bronchoscopy who require muscle…
- Conditions
- Anesthesia, Bronchoscopy, Muscle Relaxants
- Trial name
- NCT06709066
- Testing
- mivacurium chloride, succinylcholine
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Peng Liang
Chronic Kidney Disease
Measuring Sleep Quality With Puki in Hemodialysis Patients Performing Progressive Muscle Relaxant Exercises
Chronic kidney disease is a chronic disease that negatively affects the quality of life of individuals, physically, socially and psychologically.
- Trial name
- NCT05604833
- Testing
- Progressive Muscle Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Muscle Relaxants
The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy
This study aimed to compare the effect of no muscle relaxants and reduced-dose rocuronium on the anesthetic induction and emergence with fentanyl in children undergoing adenotonsillectomy.
- Trial name
- NCT02467595
- Testing
- Rocuronium bromide 0.15 mg kg-1, Rocuronium bromide 0.3 mg kg-1, Fentanyl
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Muscle Relaxant, General Anesthesia
Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose
This study aimed to evaluate the effect of Neostigmine partial dose towards neuromuscular blockade of rocuronium
- Trial name
- NCT03058263
- Testing
- Dose of Neostigmine
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Muscle Relaxants
Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle relaxants are medications used during surgery to facilitate surgical access. The effect of the muscle relaxant medications is measured by stimulation a motor nerve and measuring the force of the resultant muscle…
- Trial name
- NCT02425449
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Flaccid Muscle Tone
Mapping Human Muscle Satellite Cell Fate By Real-Time Imaging
Mapping Human Muscle Satellite Cell Fate By Real-Time Imaging
- Trial name
- S48 (NCT02685319)
- Testing
- muscle biopsy
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Purdue University
Entropy Device and How Will Muscle Relaxants Affect it
Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia
Many studies have explored the effects of inhalation anesthetics, intravenous anesthetics, and muscle relaxants on spectral entropy, but most did not monitor the degree of neuromuscular block.
- Trial name
- NCT05097508
- Testing
- Atracurium Besylate, Rocuronium Bromide, Entropy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, General
Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly
Laryngeal mask airway (LMA) is currently the most widely used supraglottic airway device with advantages of simple and fast placement, reduced anesthesia drug use, more stable hemodynamics, and less throat discomfort after…
- Trial name
- LMA (NCT05310110)
- Testing
- 10% lidocaine spray, Cisatracurium, Propofol
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
TOF, Sex
Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System
To explore and compare the effects of propoful, sevoflurane, and a combination of both on the pharmacokinetics and pharmacodynamics of rocuronium.
- Trial name
- NCT02364934
- Testing
- Propofol, Sevoflurane
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Preterm Birth
Hammock Positioning's Influence on the Electromyographic Activity in the Flexor Muscles in Newborn Preterm
The individual who is born premature, in addition to a CNS still in accelerated training suffers early loss of intrauterine restraint, conditions that promote hypotonia characteristic of premature birth.
- Trial name
- NCT02621996
- Testing
- hammock, containment nest
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Hypotonia-Cystinuria Syndrome, Muscle Hypotonia
PREPL in Health and Disease
Evaluation of PREPL activity in healthy controls and known or possible PREPL deficient patients
- Conditions
- Hypotonia-Cystinuria Syndrome, Muscle Hypotonia, Healthy Volunteers, Dwarfism, Growth Hormone Deficiency
- Trial name
- PHD (NCT02263781)
- Testing
- Blood draw, muscle biopsy
- Where
- Belgium
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Flaccidity, Muscle
Efficacy and Safety of Poly-L-lactic Acid
This study aims to assess efficacy and safety of Sculptra in the treatment of skin flaccidity in selected areas - arms, anteromedial region, and gluteal regions.
- Trial name
- Sculptra (NCT03225066)
- Testing
- Poly-L-lactic acid - Sculptra
- Where
- 4 sites in Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Galderma Brasil Ltda.
Intubation; Difficult or Failed, Muscle Relaxation
Use of Muscle Relaxants in Parotidectomy Operation With Neuromonitoring
Neuromuscular blockers provide muscle relaxation by blocking the electrical conduction to motor nerves and facilitate endotracheal tube placement while relaxing the whole body for surgical comfort during general anesthesia.
- Conditions
- Intubation; Difficult or Failed, Muscle Relaxation, Anesthesia Intubation Complication, Airway Complication of Anesthesia
- Trial name
- NCT05432570
- Testing
- Group A - Muscle Relaxants Used, Group B - No Muscle Relaxants
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Muscle Tone Poor, Spinal Muscular Atrophy
Myotonometer Intra- and Inter Examiner Reliability on Spinal Muscular Atrophy
The primary aim of the study was to measure the intra-rater and inter-rater reliability of MyotonPRO in measuring postural muscle tone and mechanical properties in individuals with spinal muscular atrophy (SMA).
- Trial name
- NCT05521217
- Testing
- MyotonPRO
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Pain, Postoperative
Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty
This is a prospective, cluster-randomized, two-arm, comparative study aimed at determining whether addition of tizanidine ( an oral muscle relaxant) to a multimodal pain regimen following primary TKA reduces opioid consumption.
- Trial name
- NCT04574791
- Testing
- TiZANidine 2 MG Oral Capsule
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Prader-Willi Syndrome
GH in Adults With PWS, Effect on Hypotonia Evaluated by Functional MRI, Relationship With Strength and Body Composition
Prader-Willi syndrome (PWS) is a genetic disorder associated with growth hormone (GH) deficiency, central hypotonia and hyperphagia that leads to life-threatening obesity.
- Trial name
- NCT03616509
- Testing
- Growth hormone
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Postoperative Pain
Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses
Intubation is a procedure that requires well relaxed muscles while general anesthesia is performed. In order to get adequate muscle relaxation, remifentanil, sevoflurane or both agents in combination have been reported as they…
- Trial name
- NCT02440204
- Testing
- Intubation, Remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Severance Hospital