Clinical trials: Muscle Relaxants
Low Back Pain
Tolerability, Safety and Activity of a Muscle Relaxant Molecule IDN5243 in Patients With Low Back Pain
This is a prospective cohort study, open-label, uncontrolled proof of concept trial. The trial objective is to evaluate the analgesic tolerability, safety and activity of IDN 5243 (3-glycosyl-3-O-demethylthiocolchicine…
- Trial name
- IDN5243inLBP (NCT02568826)
- Testing
- 3-glycosyl-3-Odemethylthiocolchicine derivative
- Where
- Italy
- Sponsor
- Indena S.p.A
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Disease of Respiratory System
Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures
The purpose of this clinical trial is to observe the use of low-dose muscle relaxants in bronchoscopy intervention surgeries, compared with no muscle relaxants, in terms of the satisfaction of tracheal tube insertion after…
- Trial name
- NCT07035301
- Testing
- Lidocaine Intravenous Infusion, Remimazolam Tosilate, Remifentanil
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Harbin Medical University
Adult Participants Requiring Tracheal Intubation Under General Anesthesia for Elective Surgery
Efficacy and Safety of HRS-9190 in General Anesthesia
A multicenter, randomized, double - blind, placebo - controlled, parallel - group phase III clinical trial was carried out to evaluate the efficacy and safety of HRS - 9190 for skeletal muscle relaxation during tracheal…
- Trial name
- NCT07733245
- Testing
- Administration of intravenous HRS-9190, Administration of intravenous rocuronium
- Where
- China
- Volunteers
- 320 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Postoperative Residual Curarization
Muscle Relaxants and Post-Anesthesia Complications
This Germany-wide, multi-center, epidemiologic study is designed to evaluate the incidence of post-operative/anesthesia effects of muscle relaxants (i.e.
- Trial name
- PORC (NCT00753389)
- Testing
- None (anesthesia)
- Where
- Germany
- Volunteers
- 20,000 people
- Sponsor
- Technical University of Munich
Pain
Interaction of Statins and Nondepolarizing Muscle Relaxants
provide evidence for prevention or reduction muscle pain.
- Trial name
- NCT02222519
- Testing
- Rocuronium
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huang-wei LV
Anesthesia
Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia
Myorelaxation is generally used as a part of general anesthesia for interventional rigid bronchoscopy. Succinylcholine is most often used because its short duration of action but rocuronium can be used since sugammadex permits a…
- Trial name
- Broncho-SR (NCT01579864)
- Testing
- succinylcholine, rocuronium
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Hopital Foch
Muscle Relaxant
Comparison of Intubating Condition of the Mcgrath Videolaryngoscope With and Without Muscle Relaxant
The objective of this study was to evaluate intubating condition using the McGrath® VL Series 5, with and without muscle relaxant
- Trial name
- NCT02575716
- Testing
- Videolaryngoscope
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Sugammadex
Effectiveness of Sugammadex on Muscle Relaxant Reversal in Preterm Neonates
The primary aim of the work is to compare the efficacy of Sugammadex and neostigmine in reversing rocuronium-induced muscle relaxation to reach complete recovery of neuromuscular block (TOF ratio≥ 0.9) in preterm neonates.
- Trial name
- NCT04566796
- Testing
- Sugammadex, Neostigmine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Muscle Relaxants
The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy
This study aimed to compare the effect of no muscle relaxants and reduced-dose rocuronium on the anesthetic induction and emergence with fentanyl in children undergoing adenotonsillectomy.
- Trial name
- NCT02467595
- Testing
- Rocuronium bromide 0.15 mg kg-1, Rocuronium bromide 0.3 mg kg-1, Fentanyl
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Cardiovascular Surgery, Bispectral Index
BIS Monitoring in Relation to Muscle Relaxant Administration
The purpose of this study is to determine the overall optimal timing of when the Bispectral Index (BIS) monitor should be started: before or after the muscle relaxant is given.
- Conditions
- Cardiovascular Surgery, Bispectral Index, Anesthesia
- Trial name
- NCT05440058
- Testing
- Bispectral Index (BIS) monitoring system
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Muscle Relaxant Consumption, Mechanical Ventilation
The Impact of Ventilator Synchrony on Muscle Relaxant Consumption and Surgeon Satisfaction During Laparoscopic Cholecystectomy.
The goal of this clinical trial is to investigate the Impact of adding SIMV Synchronization to our standard PCV-VG mode of ventilation on muscle relaxant consumption, the frequency of relaxant top-ups and surgeon satisfaction…
- Conditions
- Muscle Relaxant Consumption, Mechanical Ventilation, Laparoscopic Cholecystectomy
- Trial name
- NCT07647770
- Testing
- Non-Synchronized Group (Control), Synchronized group
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Hitham Mohammed Aly Elsayed
Acute Low Back Pain
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Low back pain causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In a general low back pain (LBP) population, prognosis is poor.
- Trial name
- NCT01587274
- Testing
- Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Montefiore Medical Center
Neuromuscular Blockade, Anesthesia
Rocuronium Dose Finding Study After Single-shot or Steady-state Propofol Anesthesia
This study is designed to determine the effective-doses ED-50 and ED-95 (the doses required for a 50% and 95% twitch inhibition, respectively) of the non-depolarizing muscle relaxant rocuronium after single-shot or steady-state…
- Trial name
- ROSANNA (NCT02054468)
- Testing
- Single-Shot Propofol, 30min infusion Propofol, Remifentanil infusion
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Technical University of Munich
Back Pain, Acute Pain
Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study
This was an interventional, double-blind, placebo controlled, randomized, single dose, proof-of-concept study. It was a single-center clinical trial.
- Trial name
- NCT04799041
- Testing
- GTX 2/3
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Algenis SpA
Muscle Relaxant
Small Doses Muscle Relaxant in General Anesthesia
This study will be held to assess the effect of minimal dose muscle relaxant on postoperative pulmonary function. The time to extubation in minutes will be the primary outcome as a clinical indicator of the return of muscle…
- Trial name
- relaxant (NCT04344262)
- Testing
- Atracurium Besylate regular dose, Atracurium Besylate minial dose
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Muscle Relaxants
Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle relaxants are medications used during surgery to facilitate surgical access. The effect of the muscle relaxant medications is measured by stimulation a motor nerve and measuring the force of the resultant muscle…
- Trial name
- NCT02425449
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Bradycardia, Neostigmine Adverse Reaction
0.6 vs. 1.2 mg Atropine Together With Neostigmine 2.5 mg on Heart Rate in Patient Receiving Muscle Relaxant
Balanced general anesthesia with neuromuscular blocking agents has been widely used for surgery.. At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects…
- Conditions
- Bradycardia, Neostigmine Adverse Reaction, Adverse Reaction to Belladonna or Atropine
- Trial name
- NCT02186132
- Testing
- Atropine 0.6 mg, Atropine 1.2 mg
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Underdosing of Skeletal Muscle Relaxants for Laparotomy, Reversal of Skeletal Muscle Relaxant
Optimal Relaxation Technique for Laparotomies With Rocuronium Infusion Followed by Sugammadex Reversal
Muscle relaxation using rocuronium infusion with sugammadex reversal hypothetically provide better quality of muscle relaxation and rapid recovery from anaesthesia compared with intermittent bolus of rocuronium muscle relaxant…
- Trial name
- ProjectO5Rs (NCT01539044)
- Testing
- Neostigmine, atropine, Sugammadex
- Where
- Malaysia
- Volunteers
- 49 people
- Sponsor
- Hospital Sultanah Aminah Johor Bahru
Prostate Cancer
The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer
The purpose of this study is to determine if there is a difference in intra-abdominal pressure which surgeons use during surgery and post-surgery pain in men who undergo robotic prostate surgery with deep neuromuscular blockade…
- Trial name
- NCT03808077
- Testing
- Rocuronium 0.3mg/kg/hr, Rocuronium 1.5mg/kg/hr
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Memorial Sloan Kettering Cancer Center