Clinical trials: Muscle Spasms
Muscle Cramps, Cirrhosis
Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study
The purpose of this study is to determine the safety and efficacy of the medication Baclofen for treatment of muscle cramps in patients with cirrhosis.
- Trial name
- NCT02298868
- Testing
- Baclofen
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Peripheral Arterial Disease
Supervised Treadmill Exercise and Ranolazine for Intermittent Claudication of Lower Extremities
The goal of this study is to evaluate whether supervised treadmill exercise combined with ranolazine 1000 mg twice daily provides an incremental benefit in absolute walking distance over supervised exercise alone in patients with…
- Trial name
- STERILE (NCT00914316)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Corewell Health East
Pain, Spasm
An Effectiveness and Safety Study of Cyclobenzaprine HCl Alone or in Combination With Ibuprofen for Acute Back or Neck Muscle Pain With Muscle Spasm
The purpose of this study is to evaluate the effectiveness and safety of cyclobenzaprine HCl 5 mg (muscle spasm medication) taken three times a day, alone or in combination with ibuprofen 400 mg or 800 mg (pain relief medication)…
- Trial name
- NCT00246389
- Testing
- cyclobenzaprine hydrochloride
- Volunteers
- 1,000 people
- Sponsor
- McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
Infantile Spasm
A Novel Approach to Infantile Spasms
This study proposes to assess the efficacy of Cosyntropin Injectable Suspension, 1 mg/mL compared to vigabatrin. Additionally, this study proposes to determine efficacy of combination therapy of Cosyntropin Injectable Suspension…
- Trial name
- NCT03347526
- Testing
- Cosyntropin Injectable Suspension, 1 mg/mL, Cosyntropin Injectable Suspension 1 MG/ML + vigabatrin, Vigabatrin
- Where
- 14 sites in United States
- Volunteers
- 394 people
- Sponsor
- University of Colorado, Denver
Dialysis; Complications
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium Levels
Individuals with ESKD and treated with hemodialysis have a high mortality risk. Associative studies suggest a relationship between serum magnesium concentration and mortality risk.
- Trial name
- OMAGOD-1 (NCT07565779)
- Testing
- A - Dialysate magnesium 0.75, B - Dialysate magnesium 1.00 mmol/L
- Where
- 4 sites in Belgium
- Volunteers
- 54 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Muscle Cramp
Oral Carnitine for Cramps in Pregnancy
Muscle cramps occur frequently among pregnant women, and few therapeutic options exist. This is a study of oral L-carnitine, a dietary supplement, for the treatment of muscle cramps in pregnancy.
- Trial name
- NCT00516516
- Testing
- L-Carnitine
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Spasms, Infantile, Prednisolone
Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no Maintenance Course of Prednisolone for the Treatment of Infantile Epileptic Spasms Syndrome (IESS)
The goal of this clinical trial is to learn if short courses (7 days) of oral prednisolone are as effective as longer courses (14 days) in treating Infantile Epileptic Spasms Syndrome (IESS) in infants.
- Trial name
- SLISS (NCT06838559)
- Testing
- Short-Duration Oral Prednisolone with Extended Tapering, Standard Oral Prednisolone Regimen with Tapering
- Where
- 7 sites in Sri Lanka
- Volunteers
- 182 people
- Sponsor
- University of Colombo
Ketogenic Diet, West Syndrome
Ketogenic Diet vs ACTH for the Treatment of Children With West Syndrome
Children with West syndrome are prone to refractory seizures with poor neurocognitive outcome overall. The current standard of care consists of treatment with ACTH, but the grade of evidence is not high and not much RCTs are…
- Conditions
- Ketogenic Diet, West Syndrome, Infantile Spasm, ACTH
- Trial name
- NCT05279118
- Testing
- Ketogenic diet, ACTH
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences
Back Muscle Spasm, Back Pain
Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm
This is a double-blind, randomized, placebo-controlled, multicenter study of the efficacy and safety of tolperisone (a non-opioid) or placebo administered in subjects with pain due to acute back muscle spasm.
- Conditions
- Back Muscle Spasm, Back Pain, Back Strain, Back Spasm Upper
- Trial name
- RESUME-1 (NCT04671082)
- Testing
- Tolperisone Hydrochloride
- Where
- 56 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- Neurana Pharmaceuticals, Inc.
Injuries, Spinal Cord, Pain
Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury
Purpose: To evaluate the efficacy and safety of levetiracetam on chronic neuropathic pain after spinal cord injury, and to examine its effect on spasms and evoked pain.
- Trial name
- NCT00252954
- Testing
- Levetiracetam
- Where
- 3 sites in Denmark
- Volunteers
- 36 people
- Sponsor
- Danish Pain Research Center
Statin Intolerance
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes.
- Trial name
- NCT02490527
- Testing
- Pure epicatechin capsules (50mg), Simvastatin (40mg)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Muscle Cramps, Aromatherapy
The Effect of Aromatherapy Massage Applied to Hemodialysis Patients With Muscle Cramp
This study is a randomized controlled and single-blind study consisting of qualitative and quantitative stages to evaluate the effect of aromatherapy massage on cramp frequency, cramp pain severity and quality of life in crampy…
- Conditions
- Muscle Cramps, Aromatherapy, Hemodialysis, Quality of Life
- Trial name
- NCT04874857
- Testing
- Lavandula angustifolia, Rosmarinus officinalis L. and Origanum majorana L., Baby oil
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Ineffective Motility, Diffuse Esophageal Spasms
Reversibility of Dysmotility After Gastric Banding
In the current study we plan to evaluate the effects of the conversion from gastric banding to gastric bypass on esophageal function using combined monitoring.
- Conditions
- Ineffective Motility, Diffuse Esophageal Spasms, Achalasia-Like Dysmotility
- Trial name
- NCT00680030
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Tremor, Involuntary Movements
Hyperkinetic Movements in Patients With Disease of Motor Neurons and Their Response to Treatment With Nusinersen
Hyperkinetic movement disorders in patients with diseases of motor neurons will be studied. Patients with spinal muscular atrophy (SMA) and motor neuron disease patients will be studied.
- Conditions
- Tremor, Involuntary Movements, SMA, MND (Motor Neurone DIsease)
- Trial name
- NCT04825119
- Testing
- Nusinersen
- Where
- Slovenia
- Volunteers
- 110 people
- Sponsor
- University Medical Centre Ljubljana
Infantile Spasms
Short-term Ketogenic Diet as Compared With Conventional Long-term Trial in Refractory Infantile Spasms: A Randomized, Controlled Study
This is a randomized, controlled study to compare Short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.
- Trial name
- NCT00968136
- Sponsor
- Yonsei University
Muscle Cramps in Amyotrophic Lateral Sclerosis
Mexiletine for the Treatment of Muscle Cramps in ALS
The purpose of this study is to determine if mexiletine is effective for the treatment of muscle cramps in Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT01811355
- Testing
- Mexiletine
- Where
- 6 sites in United States
- Volunteers
- 23 people
- Sponsor
- Bjorn Oskarsson, MD
CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure
A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.
This is a Phase 3 Study to examine the efficacy and safety of ZX008 in children and adults with cyclin-dependent kinase like-5 (CDKL5) deficiency disorder (CDD).
- Conditions
- CDKL5 Deficiency Disorder, Generalized Tonic Clonic Seizure, Epileptic Spasm, Refractory Seizures
- Trial name
- GEMZ (NCT05064878)
- Testing
- Fenfluramine
- Where
- 46 sites in United States, Austria and 12 more
- Volunteers
- 87 people
- Sponsor
- Zogenix, Inc.
Hemodialysis Complication
Music Therapy for Individuals Receiving Hemodialysis Treatment
There are studies in the world where music therapy is used in the management of symptoms in hemodialysis, but the number of studies in our country is insufficient.
- Trial name
- NCT06207669
- Testing
- Music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Amasya University
Neurology Department
Abnormal Hyperkinetic Movements Post Acute Stroke
The occurrence of abnormal movements is a frequent reason for consultation in neurology. The etiologies are broadly separated into "primary causes", intrinsically neurological diseases (of genetic or degenerative origin), and…
- Trial name
- NCT05388552
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier de Saint-Denis