Clinical trials: Muscle Spasms
Liver Cirrhosis
Cyclobenzaprine in Muscle Cramps With Liver Cirrhosis
Cyclobenzaprine, is a muscle relaxer medication used to relieve skeletal muscle spasms. It is one of the best-studied drug for this application.
- Trial name
- NCT02642861
- Testing
- Cyclobenzaprine, Calcium Carbonate
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Tanta University
Muscle Cramp
Intradialytic Stretching Exercises on Prevention and Reduction of Leg Muscle Cramps
Renal replacement therapy is a treatment option for people who have acute or chronic renal failure. A patient with increasing symptoms of renal failure is referred to a dialysis and transplantation center early in the course of…
- Trial name
- NCT04901832
- Testing
- Intradialytic stretching exercises
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Kufa University
Muscle Cramp
Compression Stockings for Prevention of Hemodialysis Muscle Cramps
the Objectives of this clinical trial is : 1. examine the effect of using elastic compression stockings in the prevention of muscle cramps among hemodialysis patients. 2.
- Trial name
- NCT07293182
- Testing
- compression stockings
- Where
- 2 sites in Iraq
- Volunteers
- 82 people
- Sponsor
- Karbala University
Infantile Spasm
Characterization by Automated System on Infantile Spasmes
Infantile spasms are defined by the occurrence of epileptic episodes characterized by the appearance of very specific motor seizures, made up of rapid, repeated contractions in flexion or extension known as spasms.
- Trial name
- REASSESS (NCT06266234)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neck Pain, Back Pain
Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin
The purpose of this study was to assess the effect of cyclobenzaprine hydrochloride (HCl) extended release (CER) 15 mg capsule once daily in participants with muscle spasms associated with acute painful musculoskeletal conditions.
- Conditions
- Neck Pain, Back Pain, Spasm
- Trial name
- NCT02814565
- Testing
- Cyclobenzaprine HCl
- Where
- 10 sites in Russia
- Volunteers
- 180 people
- Sponsor
- Takeda
Masseter Muscle Spasm
Assessment of Correlation Between Changes of Shear Wave Elastography and Surface Electromyogram of the Masseter
Diagnoses and follow up of muscles diseases lack imaging. Severity assessment of masticatory dysfunction and follow up of treatment effectiveness is currently based only on clinical features.
- Trial name
- EVEREST (NCT02425839)
- Testing
- Ultrasound exam by Supersonic Shear Imaging® technique, EMG examination by electromyograph Keypoint system
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Muscle Cramp, Cirrhosis
Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis
The investigator's aim is to compare the efficacy of Ropinirole (Requip) to vitamin E in the treatment of muscle cramps in cirrhotic patients.
- Trial name
- NCT03176966
- Testing
- Vitamin E, Ropinirole, Muscle cramp survey
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Stroke Gait Rehabilitation
The Effectiveness of Laser and Extracorporeal Shock Wave Therapy in Resolving Ankle Muscle Spasm in Stroke Patients.
Stroke is one of the leading causes of long-term disability worldwide. Spasticity (muscle spasm) is a common and disabling consequence of stroke.
- Trial name
- spasticity (NCT07364110)
- Testing
- Rehabilitation Protocol, Extracorporeal Shock Wave Therapy (ESWT), High-Intensity Laser Therapy (HILT)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Necmettin Erbakan University
West Syndrome
Cortical Excitability in West Syndrome Using Transcranial Magnetic Stimulation
Currently, no literature is available regarding degree of cortical excitability and its correlation with various epileptic syndromes and disorders such as West Syndrome in pediatric age group.
- Trial name
- NCT06201897
- Testing
- ACTH/Oral Steroids
- Where
- India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Muscle Cramps Aggravated, Diabetes Mellitus
Botulinum Toxin for Cramps in Diabetic Neuropathy
Objective: previous studies suggest that botulinum toxin A (BoNT/A) can reduce muscle hyperactivity. Research Design and Methods: a single-center, double-blind and placebo-controlled study investigating the efficacy and safety of…
- Trial name
- NCT03238898
- Testing
- Botulinum toxin type A, Normal saline
- Volunteers
- 50 people
- Sponsor
- Presidio Ospedaliero Garibaldi-Centro
Muscle Tightness, Muscle Spasm
Effects of Manual Therapy Techniques on Hamstring
Hamstring shortness occurs in almost all populations worldwide, in both symptomatic and asymptomatic individuals. The causes of hamstring shortness include genetic factors, adaptation of the muscle to acute or chronic injury…
- Trial name
- NCT06473402
- Testing
- Muscle Strength Test, Hamstring Flexibility, Knee Range of Motion
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Surgical Procedures, Operative, Anaesthesia
POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe
International multicenter observational study of a random-sample cohort of patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during a continued 14-day period of recruitment.
- Trial name
- POPULAR (NCT01865513)
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 22,000 people
- Sponsor
- European Society of Anaesthesiology
Muscle Cramp, Cirrhosis
Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis
The goal of this randomized controlled trial is to compare the efficacy and safety of branched-chain amino acids (BCAA) versus placebo for treating muscle cramps in cirrhotic patients.
- Conditions
- Muscle Cramp, Cirrhosis, Quality of Life
- Trial name
- NCT05724485
- Testing
- Branched-chain Amino Acid
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Epileptic Encephalopathy, Early Infantile Epileptic Encephalopathy
IBIS - Investigating Reliability of BIS and SEDLINE Monitoring in Children With Developmental and Epileptic Encephalopathies (DEE).
When children have surgery, anaesthetists carefully monitor the depth of anaesthesia by using sensors on the forehead that measure brain activity, also known as processed electroencephalogram (pEEG).
- Conditions
- Epileptic Encephalopathy, Early Infantile Epileptic Encephalopathy, Infantile Spasm, Developmental and Epileptic Encephalopathies
- Trial name
- IBIS (NCT07585643)
- Testing
- Monitoring of patients using electroencephalogram, a Bispectral Index (BIS) and Sedline monitors.
- Where
- 2 sites in Australia, Brazil
- Volunteers
- 40 people
- Sponsor
- Telethon Kids Institute
Epilepsy
A Study of Hemodynamic Changes Using Near Infra-red Spectrometry (NIRS) in Infantile Epilepsy Spasms
This study will included 20 children presenting with epilepsy with spasms. It aims to offer these children, non invasively and without supplementary examinations, a recording of local and cerebral hemodynamic changes concomitant…
- Trial name
- SPASMES-NIRS (NCT02899832)
- Testing
- NIRS
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hyperkinesis
Single Photon Emission Computed Tomography (SPECT) to Study Paroxysmal Hyperkinetic Movement Disorders
This study will use single photon emission computed tomography (SPECT) to determine what areas of the brain are responsible for paroxysmal hyperkinetic movement disorders.
- Trial name
- NCT00051337
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cervicalgia, Low Back Pain
New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain
This protocol is a prospective, open label, pilot study examining the utility of three established pain questionnaires (the Visual Analogue Scale (VAS), Neck Disability Index (NDI), the Oswestry Low Back Pain Questionnaire and…
- Trial name
- NCT02008136
- Testing
- Botulinum Toxins
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Connecticut Healthcare System
Infantile Spasms
Open-label Extension to Protocol 1042-0500
To allow open-label extension to patients who have completed Protocol 1042-0500
- Trial name
- NCT00442104
- Testing
- Ganaxolone
- Where
- 14 sites in United States
- Volunteers
- 54 people
- Sponsor
- Marinus Pharmaceuticals
Epilepsy, Dravet Syndrome
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
The purpose of this study is to investigate the effect on the frequency of all seizures (convulsive and drop) in participants treated with TAK-935 compared to placebo.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- ELEKTRA (NCT03650452)
- Testing
- TAK-935
- Where
- 44 sites in United States, Australia and 6 more
- Volunteers
- 141 people
- Sponsor
- Takeda
Spinal Cord Injuries
Vibration for Muscle Spasms After Spinal Cord Injury
This study uses closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms responsible for spasm generation change in…
- Trial name
- NCT03598504
- Testing
- Wearable EMG/Vibration device
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab