Clinical trials: Muscle Spasticity
Spasticity
Retrospective Real-Life Study From One Brazilian Reference Center Assessing Long-Term Experience In The Treatment Of Adult Spasticity With AbobotulinumtoxinA
The aim of the study is to describe the long-term use of abobotulinumtoxinA (Dysport®) in adult subjects affected with upper limb spasticity (ULS) +/- lower limb spasticity (LLS) who received treatment with Dysport® for a minimum…
- Trial name
- RETURN (NCT04446702)
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ipsen
Spinal Cord Injuries, Muscle Spasticity
Cyproheptadine and Chlorpromazine Effects on Spasticity
The main goal of this research is to understand the neuronal mechanisms that mediate the development of spasticity and motor dysfunction after spinal cord injury.
- Trial name
- NCT01509885
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Spasticity
Definition, Assessment and Treatment of Spasticity According to Physiotherapists and Occupational Therapists in Flanders, Belgium: A Cross-sectional Qualitative Study.
The definition of spasticity described by Lance in 1980 provided a strong academic foundation for characterizing this neurological symptom.
- Trial name
- NCT06956534
- Testing
- Questionnaire and Physical Exam
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Spasticity, Multiple Sclerosis, Stroke, Trauma
Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity
Spasticity - movement disorder, which is part of the syndrome of defeat top motor-neuron, characterized by the rate-dependent increase in muscle tone and increased dry-core reflections from hyperexcitability of stretch receptors…
- Trial name
- ANTMS (NCT01786005)
- Testing
- Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Spastic Cerebral Palsy
3D-Microscopic Muscle Architecture in Cerebral Palsy
The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to…
- Trial name
- 3D-MMAP (NCT06584851)
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spasticity, Muscle, Muscular Diseases
Using Telemedicine to Improve Spasticity Diagnosis Rates
The purpose of this study is to test the reliability of using telemedicine so a neurologist can remotely identify residents of a long-term care facility who should be referred to a neurologist for an in-person spasticity…
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03211390
- Testing
- Neurological Examination, Teleneurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Muscle Spasticity, Stroke
Measurements of Displacement Amplitude and Angular Velocities During Passive Extension of the Wrist and Hand Complex in Stroke Patients
The main objective of this monocentric prospective study is to evaluate the amplitudes and angular velocities of extension of the hand and wrist joints during passive mobilization by a physiotherapist in healthy subjects and…
- Trial name
- PHYSIOHAND (NCT04502927)
- Testing
- Passive extension mobilization of the hand and wrist joints
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Stroke
Investigation of the Use of Acupuncture for the Treatment of Spasticity in Chronic Stroke Participants
The purpose of this study is to investigate if acupuncture is more effective than sham treatment in reducing lower extremity spasticity, and improving gait speed in the chronic phase of stroke recovery.
- Trial name
- HHSCSTROKEAC (NCT02085642)
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Hemiplegia
Comparison of the Effects of Extracorporeal Shock Wave Therapy and Dry Needing
Effective treatment of spasticity after stroke is a very important and serious problem. Some of the therapeutic approach include physiotherapy and medication.
- Trial name
- NCT05952830
- Testing
- ESWT group, DN group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Spasticity, Muscle, Muscular Diseases
Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility
The purpose of this study is to improve spasticity diagnosis through exploration of potential new diagnostic markers for spasticity that can assist in diagnosis and referral.
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03250988
- Testing
- Neurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Baclofen Withdrawal Syndrome
Oral and IV Baclofen in Adult Volunteers
The primary objective of this study is to characterize baclofen pharmacokinetics following oral and intravenous administration in patients who are on chronic oral baclofen therapy.
- Trial name
- NCT01749319
- Testing
- Oral baclofen, Intervenous baclofen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke
Upper Limb Training Modalities in Patients With Stroke
To date, evidence of the effects of robotic training combined with OnabotulinumtoxinA focal treatment for spasticity is limited.
- Trial name
- NCT03590314
- Testing
- Experimental group - robot assisted arm training (Armotion®), Control group - conventional treatment
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Stroke, Muscle Spasticity
Dry Needling for Spasticity in Stroke
The study team is recruiting 20 adults with spasticity due to chronic stroke and 20 adults with no neurological injuries for a 2 day study.
- Trial name
- NCT04535479
- Testing
- Dry Needling
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Spastic Diplegic Cerebral Palsy
Repetitive Transcranial Magnetic Stimulation Versus Botulinum Injection on Spasticity on Children With Diplegic Cerebral Palsy
This trial will enroll 75 children with spastic diplegic cerebral palsy both matched in age, sex, degree of disability and cognitive functions with the same exclusion criteria undergoing the same physical therapy.
- Trial name
- NCT06218316
- Testing
- botulinum toxin A, Transcranial Magnetic Stimulation, Rehabilitation Training Protocol
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MTI University
Stroke, Cerebral
Benefits of Extracorporeal Shockwave Therapy to Reduce Spasticity in Stroke/CP
This Study will help to explain us that ExtracorporealShockwave therapy can reduce spasticity in Stroke Patient,help them to restore their abilities and ROM.Therapy reduces dependency rate of patient.Also seen this therapy shows…
- Trial name
- NCT06548321
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Superior University
Multiple Sclerosis
Dry Needling for Treating Spasticity in Multiple Sclerosis
The aim of the study is to evaluate the efficacy of dry needling (DN) in the treatment of spasticity in patients with multiple sclerosis (MS).
- Trial name
- NCT05351957
- Testing
- Dry needling
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Canarias
Spinal Cord Injuries, Muscle Spasticity
Effects of Zolmitriptan on Sensory Transmission After Spinal Cord Injury
After spinal cord injury, patients develop a spastic syndrome that is characterized by hyperactive reflexes, increased muscle tone, clonus and involuntary muscle spasms.
- Trial name
- NCT01587170
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hemiparesis;Poststroke/CVA
Strengthening in Sub-acute Stroke Survivors: A Randomized Controlled Trial
The goal of this study is to compare between Eccentric training and conventional therapy in sub-acute stroke survivors. The primary objective of this study is to evaluate improvements in gait speed after four months of ET in…
- Trial name
- NCT06140381
- Testing
- Eccentric training, Conventional therapy
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinique Du Parc de Belleville
Spasticity
Prevalence of Spasticity in Veterans Living in a Long-term Care Facility
The purpose of the study is to conduct a feasibility survey of the prevalence of spasticity at a single long-term care facility for veterans and their spouses in Murfreesboro, Tennessee.
- Trial name
- NCT01879449
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University