Clinical trials: Muscle Synthesis
Amino Acids, Dietary Protein
Influence of Sex and Training on de Novo Muscle Protein Synthesis
Acute exercise increases the incorporation of dietary amino acids into de novo myofibrillar proteins after a single meal in controlled laboratory studies in males.
- Conditions
- Amino Acids, Dietary Protein, Sex, Resistance Exercise
- Trial name
- TUT (NCT04887883)
- Testing
- Resistance exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Heart Failure, Type 2 Diabetes
Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function
The major goal of this study is to characterize the ability of dark chocolate enriched in epicatechin (a component of dark chocolate) to improve the structural and functional features of mitochondria in two groups 1.
- Trial name
- NCT01671514
- Testing
- Epicatechin-enriched dark chocolate, Low-epicatechin dark chocolate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Vitamin D Effects on MPS, Placebo Effects on MPS
Effects of Vitamin D Supplementation on Muscle Protein Synthesis
Background: Healthy adults maintain muscle tissue by continuously building up and breaking down muscle proteins throughout the day.
- Trial name
- VIPER (NCT06746389)
- Testing
- 3000 IU per Day Spray
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Kidney Diseases, Muscle Loss
Protein and Exercise Training in Chronic KIDNEY Disease
When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent.
- Trial name
- PET KIDNEY (NCT05482243)
- Testing
- Whey protein
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight
Daily Protein Intake Distribution and MPS (ARCIII)
To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis
- Trial name
- NCT02315014
- Testing
- whey protein
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Muscle Protein Synthesis, Sarcopenia
The Impact of a Whole-food Animal-based Versus Plant-based Protein Rich Meal on Muscle Protein Synthesis
Rationale: Food intake stimulates muscle protein synthesis rates. The magnitude of the anabolic response to feeding forms a key factor in regulating muscle mass maintenance.
- Trial name
- MeaL (NCT05151887)
- Testing
- Muscle protein synthesis
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Elderly Muscle, Anabolically Resistant Elderly Muscle
Protein Nutrition for Muscle Hypertrophy in Older Adults
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.
- Trial name
- NCT02315391
- Testing
- isolated whey protein, micellar whey protein, glycine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Aging, Sarcopenia
Leucine Co-ingestion and Myofibrillar Protein Synthesis in Older Adults
The loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by a suppressed MPS response to protein ingestion.
- Trial name
- NCT02371278
- Testing
- Leucine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Adult Participants
Yeast Protein for Muscle Mass
Protein supplementation is said to be one of the cost-efficient and practical strategies to meet protein needs for growth and exercise, and can help maximize muscle gain from resistance exercise.
- Trial name
- NCT07561619
- Testing
- Yeast Protein, Resistance Training Exercises, Whey Protein
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Muscle Synthesis
Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults
During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility.
- Trial name
- NCT01847261
- Testing
- Soy Dairy Protein Blend, Positive Control (Dairy Whey Protein)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Healthy
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
- Trial name
- NCT03571425
- Testing
- Oral Protein, Enteral Protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Aging
The Effects of Whey vs. Collagen on MPS
With aging there is a natural loss of muscle mass and strength called sarcopenia, which increases the risk of falls and metabolic disease (i.e. Type II diabetes) and decreases the ability to perform activities of daily living.
- Trial name
- NCT03281434
- Testing
- Collagen peptide, Whey protein isolate
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
Combined Nutrient Intake and Muscle Protein Synthesis
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and…
- Trial name
- NCT01239277
- Testing
- protein, protein and carbohydrate, protein and leucine
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Age-related Degenerated Disease
Relationships Between Quality of Ageing and Age-related Degenerated Disease (Compalimage)
This project aims to assess the impact of chronic micro-inflammation on age-related loss of muscle (sarcopenia) and bone (osteopenia).
- Trial name
- Compalimage (NCT00862615)
- Testing
- Measurement of muscle protein synthesis using stable isotopes and muscle biopsies.
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Inflammatory Bowel Diseases, Sarcopenia
Phenotyping of Adult Crohn's Focusing on Sarcopenia
Inflammatory bowel disease (IBD) includes two idiopathic chronic relapsing and remitting inflammatory conditions affecting the gastrointestinal (GI) tract: Crohn's disease (CD) and ulcerative colitis (UC)Malnutrition and…
- Conditions
- Inflammatory Bowel Diseases, Sarcopenia, Digestive System Disease, Nutrition, Healthy
- Trial name
- PACS (NCT05572203)
- Testing
- Intrinsically labelled protein
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Loss
Muscle Protein Synthesis in Dialysis Patients
The most severe form of chronic renal failure is end-stage-renal-disease with maintenance hemodialysis (MHD) as the most common treatment strategy.
- Trial name
- NCT03478722
- Testing
- Protein Meal, Stable Isotope Amino Acid Infusion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Sarcopenia
Postprandial Muscle Protein Synthesis Following Wheat Protein Ingestion in Vivo in Humans
Rationale: The progressive loss of skeletal muscle mass with aging, or sarcopenia, has a major impact on our health care system due to increased morbidity and greater need for hospitalization and/or institutionalization.
- Trial name
- NCT01952639
- Testing
- protein type and amount
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthetic Response to Protein
Nutritional and Physical Intervention During Bed Rest
Hospitalization often involves long periods of bed rest and reduced nutritional intake, which can lead to skeletal muscle loss and anabolic resistance.
- Trial name
- Bed-Plant (NCT07280819)
- Testing
- Nutritionally complete tube feed providing a sole source of nutrition with a plant-dominant protein mix, Nutritionally complete tube feed providing a sole source of nutrition with an animal-based protein mix, Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Skeletal Muscle Atrophy
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- PoEMS (NCT05997095)
- Testing
- Neuromuscular electrical stimulation (NMES/0
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Study of Inactivity on Metabolism of Elderly Muscles
Skeletal muscle mass declines with inactivity (casting is a good example) and increases with activity (such as weightlifting). Whether muscle mass increases or decreases, is determined by whether more new proteins within muscle…
- Trial name
- NCT01818609
- Testing
- Step reduction
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University