Clinical trials: Muscle Wasting
Muscular Atrophy, Spinal
Bioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants
The study is a randomized, single oral dose, crossover study in up to three parts to investigate the relative bioavailability and bioequivalence of two different formulations of risdiplam 5 mg (dispersible tablets) versus the…
- Trial name
- NCT04718181
- Testing
- risdiplam, omeprazole
- Where
- 4 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Aging, Physical Activity
Exercise Periodization and Older Adults
The present study aimed at investigating the effects of two different resistance training protocols - nonperiodized (NP) and daily undulating periodization (DUP) - on hemodynamic, morphofunctional and cognitive parameters of…
- Conditions
- Aging, Physical Activity, Sarcopenia, Cognitive Decline
- Trial name
- NCT03443375
- Testing
- Physical exercise
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Sarcopenia
Detection and Treatment of Sarcopenia and Myosteatosis in Older African Americans
The objectives of this study are to: 1) validate a rapid, portable, cost-effective method for screening myosteatosis and sarcopenia using diagnostic ultrasound, and 2) investigate a novel approach to progressive resistance…
- Trial name
- ARMS-II (NCT02350465)
- Testing
- Eccentric Exercise, Concentric Exercise
- Where
- 3 sites in United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Muscle Wasting, Protein Intake
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat…
- Conditions
- Muscle Wasting, Protein Intake, Ketosis, Caloric Restriction
- Trial name
- NCT04744142
- Testing
- Ketone supplementation, Increased protein intake
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Arthritis, Rheumatoid, Knee Osteoarthritis
Can 4 Weeks of Exercise Program Change Quadriceps Architecture in Patients With Rheumatoid Arthritis
Quadriceps femoris (QF) atrophy is seen in rheumatoid arthritis and knee osteoarthritis (OA) patients. Exercise therapy is mile stone in knee OA patients also it can help thicken QF muscle of RA patients.
- Conditions
- Arthritis, Rheumatoid, Knee Osteoarthritis, Quadriceps Muscle Atrophy, Ultrasonography
- Trial name
- NCT04834050
- Testing
- Quadriceps femoris isometric home-based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ovgu Bickici
Sarcopenia
Auto-regulated Resistance-training for Older Adults
This research study is comparing the effect of traditional standardized, subjective auto-regulated, and objective auto-regulated resistance training on physiological adaptations and performance measures in adults aged 50 years or…
- Trial name
- NCT05580913
- Testing
- Resistance training
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Obesity, Sarcopenia
The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults
Age-related changes in body composition, muscular fitness, and metabolic health resulting in the onset of obesity, sarcopenia, and chronic diseases are profound public health issues that are in need of immediate attention.
- Conditions
- Obesity, Sarcopenia, Aging
- Trial name
- NCT04127240
- Testing
- DASH diet containing daily intakes of red meat
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Sarcopenia
Diagnostic Evaluation of Sarcopenia in Elderly Patients
Sarcopenia is a generalized progressive skeletal muscle disorder that represents a related physiological vulnerability that is associated with or increases the likelihood of adverse outcomes, including falls, fractures, physical…
- Trial name
- NCT04451005
- Testing
- 0
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sarcopenia
Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally
The overall aim of the TEMPUS-FUGIT study is to assess gut microbiota composition in older persons without sarcopenia and to determine the relationship with and between intestinal and systemic inflammation and with…
- Trial name
- TEMPUS-FUGIT (NCT05008770)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atrophy, Muscular
31P MRS Ischaemic Exercise Optimisation and COPD
An MRI study to develop a reliable methodology for 31P MRS ischaemic exercise in order to obtain a consistent standard of measurement of muscle metabolism while maintaining an acceptable level of subject comfort and use optimised…
- Trial name
- NCT01476072
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bulbo-Spinal Atrophy, X-Linked, Kennedy Disease
MRI in Patients With Kennedy Disease
Kennedy disease is an inherited neuromuscular disorder that is characterized by progressive muscle wasting and weakness. It typically starts with muscle spasms and tremors in the arms, followed by muscle weakness and atrophy of…
- Trial name
- NCT02501395
- Testing
- No intervention, observational
- Where
- Denmark
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atrophy, Disuse, Muscle Atrophy
Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse.
- Conditions
- Atrophy, Disuse, Muscle Atrophy, Muscular Disorders, Atrophic, Disuse Atrophy
- Trial name
- NCT06228742
- Testing
- Unilateral leg immobilization, Contralateral active leg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Trapezius Muscle Atrophy
Trapezius Muscle Activities in the Natural Head Posture and Corrected Head Posture During Wall-Slide Exercise
The goal of this observational study is to investigate the effect of head posture on trapezius muscle activity and ratios during wall slide exercise.
- Trial name
- NCT06872957
- Testing
- Surface Electromyography Noraxon MiniDTS system
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Weight Loss, Muscle Loss
Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency
Military personnel face many physiological challenges, including sustained physical activity and prolonged periods of negative energy balance.
- Conditions
- Weight Loss, Muscle Loss, Bone Loss
- Trial name
- NCT01292395
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Sarcopenia, Frailty
Whole Grain Job's Tear, Muscle Health, Blood Glucose and Lipid Level
Background: This investigation aims to explore efficacy of Taiwanese whole grain job's tear on muscle health and blood glucose and lipid levels in community-dwelling older adults.
- Conditions
- Sarcopenia, Frailty, Hyperglycemia, Hyperlipidemia
- Trial name
- NCT06503172
- Testing
- Taiwanese whole grain job's tear (red job's tear), White job's tear
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Sarcopenia
Screening for Age-Related Skeletal Muscle Dysfunction
This pilot study will aid the development of a sonographic screening method used to obtain proxy measures of LBM and estimates of muscle composition that relate to Intramuscular adipose tissue (IMAT), lipid metabolism, and…
- Trial name
- ARMS (NCT02277236)
- Testing
- DXA scanning, CT imaging
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Frailty, Sarcopenia
Development of Frailty Prevention Clinic in Geriatric Comprehensive Clinic RSCM:
There is an increasing number of elderly population, not only in Indonesia, but also in the world. With increasing of age, there is also an increasing number of elderly with sarcopenia and frailty.
- Conditions
- Frailty, Sarcopenia, Resistance Training
- Trial name
- NCT05511311
- Testing
- Resistance Training, Standard Therapy
- Where
- Indonesia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Sarcopenia, Body Weight Changes
Effects of Resistance Training on Physical Performance, Health and Quality of Life in Elderly (RTCHealth)
Physical exercise is considered an important intervention for promoting well-being and healthy aging. The purpose of the present study was to determine the effects of moderate-to-high intensity resistance training circuit on…
- Conditions
- Sarcopenia, Body Weight Changes, Quality of Life
- Trial name
- RTCHealth (NCT03551132)
- Testing
- Exercise test
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Sarcopenia
Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect…
- Trial name
- NCT01477164
- Testing
- High intensity aerobic exercise, Resistance exercise training, Combined
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes, Muscle Atrophy
The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults
The goal of this study is to determine the impact of pre-diabetes and type 2 diabetes on muscle atrophy during a period of bed rest and recovery of muscle mass, strength, and physical function following bed rest.
- Conditions
- Type 2 Diabetes, Muscle Atrophy, Aging, Sedentary Behavior
- Trial name
- REST (NCT03761446)
- Testing
- Bed rest
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute