Clinical trials: Muscle Wasting
Muscle Loss, Muscle Anabolism
Skeletal Muscle Response to Amino Acids and Load Carriage Exercise
Warfighters often experience physical overload, as the uniform and associated gear that they carry burdens them with substantial loads.
- Conditions
- Muscle Loss, Muscle Anabolism, Muscle Performance
- Trial name
- NCT01714479
- Testing
- Leucine-enriched nutritional supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Spinal Muscular Atrophy Type 3, Duchenne Muscular Dystrophy (DMD)
Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
The purpose of this research is (1) to identify disease specific walking-related digital biomarkers of disease severity, and (2) monitor longitudinal changes in natural environments, for extended periods of time, in DMD and SMA.
- Trial name
- NCT06839469
- Where
- 3 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Frailty Syndrome, Cognitive Impairment
Successful Aging and Frailty
Frailty is the term commonly utilized to describe the geriatric syndrome that exposes the elderly to increased risk of negative health-related events.
- Conditions
- Frailty Syndrome, Cognitive Impairment, Sarcopenia
- Trial name
- SAFe (NCT03963050)
- Testing
- Exercise Training, Exercise Training + Cognitive Training, Control
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Sarcopenia, Physical Inactivity
Women in Action: A Multicomponent Intervention for Older Women
"Women in Action" is a quasi-experimental, mixed-methods study evaluating a 16-week multicomponent intervention (supervised strength/aerobic/balance training plus psychoeducational and nutrition-focused behavioral workshops) for…
- Conditions
- Sarcopenia, Physical Inactivity, Menopause, Healthy Aging
- Trial name
- WIA (NCT07860424)
- Testing
- Multicomponent exercise, nutrition, and psychoeducational program
- Where
- 2 sites in Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Universidad de Oviedo
Spinal and Bulbar Muscular Atrophy, Healthy Subjects
High Intensity Training in Patients With Spinal and Bulbar Muscular Atrophy
We want investigate if high intensity training can increase daily functionality without causing muscle damage in patients Spinal and Bulbar Muscular Atrophy .
- Trial name
- HIT in Kennedy (NCT02156141)
- Testing
- Supervised high intensity training, Optional training, Control period
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karen Brorup Heje Pedersen
Sarcopenia, Sarcopenic Obesity
Prevalence of Sarcopenia and Sarcopenic Obesity in Older Adults
Syndromes such as sarcopenia, sarcopenic obesity and osteosarcopenic obesity are commonly seen in older adults. They result from the impairment of muscle, bone and adipose tissue.
- Conditions
- Sarcopenia, Sarcopenic Obesity, Osteopenia, Osteoporosis
- Trial name
- NCT04122638
- Where
- Turkey (Türkiye)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Goztepe Training and Research Hospital
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS
CAPTURE ALS is a long-term data and biorepository platform that will facilitate future ALS research. CAPTURE ALS will provide the standardized systems and tools necessary to collect, store, and analyze vast amounts of multimodal…
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Degeneration
- Trial name
- CAPTURE ALS (NCT05204017)
- Where
- 4 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sarcopenia
Evaluation of Sarcopenia in Women in Different Stages of Life and in Hormonal Therapy or Not
The three-year interventional study has the following objectives: The study aims to assess the prevalence of sarcopenia in menopausal women receiving hormone replacement therapy or not compared with pre-menopausal women.
- Trial name
- NCT06792201
- Testing
- SARC-F, Handgrip test, Chair stand test
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sarcopenia, Osteoporosis
The Bone-Myoregulation Reflex and Development of Sarcopenia in Osteoporosis
Bone and skeletal muscle are in a single unit that interacts with each other structurally and functionally. The aim of this study is to determine the contribution of bone myoregulation reflex as a neuronal crosstalk mechanism on…
- Trial name
- NCT06017245
- Testing
- whole-body vibration to Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sarcopenia
Sarcopenia and Combined-modality Exercise
This study examined the effects of combined-modality exercise training (resistance, endurance, flexibility and balance) on muscle mass, muscle function and physical activity in community-dwelling elderly living in Jamaica who had…
- Trial name
- NCT04806152
- Testing
- High intensity exercise, Usual care home exercise
- Where
- Jamaica
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Assessment, Self, Muscle Atrophy
Correlation of Muscle Ultrasound Measures (2D and 3D) With Biphotonic X-ray Absorptiometry in Oldest Old Patients.
The sarcopenia diagnosis is based on the muscle mass and on impaired physical performance. The emerging field of ultrasound assessment of muscle mass in older patients is based on 2d parameters with prediction equations for…
- Conditions
- Assessment, Self, Muscle Atrophy, Ultrasound Therapy; Complications, Aging
- Trial name
- DIASEM (NCT04753450)
- Testing
- No intervention
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Sarcopenia
Effectiveness of Interactive Exergame in Older Adults With Sarcopenia
Sarcopenia has been defined as an age related, involuntary loss of skeletal muscle mass and strength. The prevalence of sarcopenia is about 10% globally, and risk factors of sarcopenia includes age, lower physical activity, and…
- Trial name
- NCT04770558
- Testing
- Interactive Exergame
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Frailty, Sarcopenia
Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatric Patients
After obtaining ethical approval, 42 patients with American Society of Anesthesiologists (ASA) scores I-III who were scheduled for surgery under general anesthesia were included in our prospective study.
- Trial name
- NCT06889714
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia, Frailty
Effectiveness of Individual Physical Activity Programs to Prevent Sarcopenia and Frailty Among Older Adults
Sarcopenia and frailty could be prevented and rehabilitated through individual physical activities in the form of combined exercise that could be practiced at home in daily life.
- Trial name
- NCT06149871
- Testing
- Physical activity
- Where
- Thailand
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand
Sarcopenia, Fatigue
Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study
This study aims to explore the relationship between sarcopenia, fatigue, and orthostatic intolerance in older adults. It will be conducted among geriatric patients attending Ain Shams University Hospitals.
- Conditions
- Sarcopenia, Fatigue, Orthostatic Intolerance
- Trial name
- NCT07564830
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sarcopenia, Osteopenia
Exercise Effects on Sarco-Osteopenia in Older Men
The study determined the effects of predominately resistance type exercise in combination with protein supplements on parameters of sarcopenia and osteopenia (sarco-osteopenia) in older, community dwelling men with sarcopenia and…
- Trial name
- NCT03453463
- Testing
- exercise
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)
Up to 66 healthy elderly individuals (at least 65 years old) are recruited as subjects. They will be recruited as a subgroup to protocol ID: H-4-2013-070.
- Trial name
- CALM (NCT02115698)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital