Clinical trials: Muscle Wasting
Energy Expenditure, Atrophy, Muscular
Energy Balance in Extreme Environments: Finding the EI Limit
This project is feasibility study looking at extreme exercise and possible diet intervention study to counter muscle and weight loss during a 2 person Greenland Ski Traverse in April 2023.
- Conditions
- Energy Expenditure, Atrophy, Muscular, Energy Intake
- Trial name
- StOMPE (NCT05773469)
- Testing
- Exercise, Nutrition
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia
Technological Processes on Quality of Meat
This project aims to assess the impact of technological processes of meat, as cooking conditions, on amino acid bioavailability and protein metabolism.
- Trial name
- NCT02157805
- Testing
- beef meat
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Muscle Composition, Sarcopenia
Effects of Increased, Egg-Based Protein Intake on Muscle Composition,
This study is designed to assess the effect of a diet-controlled nutrition program utilizing an egg-based higher protein diet on muscle composition and size, and indices of metabolic health and markers of systemic inflammation in…
- Conditions
- Muscle Composition, Sarcopenia, Hypertrophy, Inflammation
- Trial name
- S25 (NCT01396915)
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Purdue University
Sarcopenia
Muscle Ultrasound for Sarcopenia Leading to Early Detection
Sarcopenia is an age-related loss of muscle mass that may affect over 25% of individuals over the age of 60 and results in a 3 to 4 times increased likelihood of developing a disability.
- Trial name
- MUSCLED (NCT02319850)
- Testing
- DXA scanning
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- George Washington University
Sarcopenia
The Characteristics of Gut Microbiota in Patients With Sarcopenia and the Development of Probiotics
The primary aim of this study is to identify the composition and characteristics of the gut microbiota in patients with sarcopenia in older adults, and compare these with the gut microbiota characteristics of older adults and…
- Trial name
- NCT07334210
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Sarcopenia
Effect of HINEX Jelly on Nutritional Status in People With Possible Sarcopenia or Sarcopenia
HINEX Jelly is a jelly high protein supplement. This report is to investigate whether jelly high protein supplement can achieve greater muscle mass, muscle strength, physical performance and nutritional status in sarcopenia or…
- Trial name
- NCT05926375
- Testing
- HINEX Jelly ( jelly high protein supplement)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Sarcopenia
Sarcopenia Physical Activity and Metabolomic
Muscle failure (sarcopenia or dynapenia) is a factor of frailty and therefore, ultimately, of loss of autonomy in the elderly. Currently, no biomarker of muscle failure has a high sensitivity, specificity and positive predictive…
- Trial name
- SPAM (NCT05199207)
- Testing
- Physical activity programm
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Muscular Atrophy
Timecourse of Immobilization Experiment
The effect of unilateral lower limb immobilisation over one week on muscle atrophy
- Trial name
- TIME (NCT02984332)
- Testing
- Lower limb immobilisation (leg brace)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia
Linking Diet, Inflammation, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study
Based on the analysis of dietary characteristics, gut microbiota diversity, and composition, this study investigates the relationships between the dietary inflammatory potential, gut microbiota, and sarcopenia.
- Trial name
- NCT07211321
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- Jianhua Ma
Sarcopenia, Gastrectomy
Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy
The investigators aimed to evaluate long-term sarcopenia in patients with total and distal gastrectomy by measuring the anterior thigh muscle with USG, which is a more specific and easy method.
- Trial name
- NCT06354348
- Testing
- USG, Grip strength, Chair stand test (CST)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Muscle Atrophy
Brain and Muscle Plasticity During Immobilization
Patients in rehabilitation may undergo periods of prolonged limb immobilization in response to injury, surgery, or illness. Due to disuse, the size and strength of muscles controlling the affected limb can decrease significantly…
- Trial name
- NCT05115643
- Testing
- Immobilization
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- McGill University
Muscle Loss
Carnitine Supplementation and Skeletal Muscle Mass
The primary aim of the current research project is to investigate the effect of carnitine supplementation on muscle strength and body composition.
- Trial name
- ROM (NCT05009641)
- Testing
- L-carnitine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics
Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly
Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge…
- Conditions
- Skeletal Muscle Protein Synthesis in Elderly, Protein Kinetics, Sarcopenia
- Trial name
- NCT01640145
- Testing
- Protein, Exercise
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Exercise Training, Skeletal Muscle
Resistance Training, Detraining, and Retraining Study 2022
The research project is aiming to examine the muscular adaptations to resistance training (RT), detraining (DT) and repeated RT (i.e. retraining).
- Conditions
- Exercise Training, Skeletal Muscle, Skeletal Muscle Atrophy
- Trial name
- TraDeRe2022 (NCT05553769)
- Testing
- Resistance training, detraining, retraining
- Where
- Finland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Muscle Loss
The Viscoelastic Properties of Lower Extremity's Muscles
This study aims to create normative values for stiffness, tonus and elasticity in the lower extremity muscles and to determine age and gender differences.
- Trial name
- NCT04289129
- Testing
- Myotonometric evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Sarcopenia
Nutritional Supplementation in the Elderly With Weight Loss
Many elderly experience weight loss and weakness with normal aging. Although there is extensive literature regarding nutritional advice for the elderly, there are few well- designed studies evaluating the effect of oral nutrition…
- Trial name
- Elderly (NCT04350762)
- Testing
- Protein shake + Fish Oil
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sarcopenia
Evaluation of the Reproducibility of Jumping Mechanography
Sarcopenia, the age-related decline in muscle mass and function (widely recognized as "frailty"), is increasingly being appreciated, primarily in the research environment.
- Trial name
- Jump (NCT01164670)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison