Clinical trials: Muscle Wasting
Muscle Loss
The Effect of Creatine on Muscle Loss
The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.
- Trial name
- CML (NCT01894737)
- Testing
- Creatine supplementation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality.
- Conditions
- Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content
- Trial name
- NR-VET (NCT04691986)
- Testing
- Nicotinamide Riboside
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy Male Volunteers Over 65
Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults
Occupying ~45-55% of body mass, skeletal muscle is the largest organ of the body and plays a pivotal role in locomotion, structural support and whole-body metabolic health.
- Trial name
- NCT06971822
- Testing
- Protein Supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Exercise, Healthy Male/Female Subjects
Ketone Administration During Inactivity and Retraining
The aim of this study is to investigate the effect of oral ketone administration during inactivity-induced muscle atrophy and retraining-induced regeneration.
- Trial name
- NCT05398042
- Testing
- Ketone ester, Medium Chain Triglyceride (MCT) oil
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Sarcopenia, Memory Loss
Effects of Multidomain Training of Health With Aging (Train-Old)
The current study aims to determine the effect of a multidomain intervention (physical fitness, motivational and cognitive training) on body composition, sarcopenia, cardiovascular health, physical fitness, functional capacity…
- Conditions
- Sarcopenia, Memory Loss, Muscular Atrophy, Cardiovascular Diseases
- Trial name
- Train-Old (NCT05481346)
- Testing
- Multidomain training
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Obesity, Overweight With Indications for Weight Loss
Optimizing Body Composition for Function in Older Adults
The purpose of this pilot study is to compare two strategies intended to improve the health of overweight older adults by improving body composition.
- Trial name
- NCT00315146
- Testing
- Pioglitazone, Resistance exercise training to maximize muscle power, Hypocaloric diet
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Malnutrition, Sarcopenia
Sustainable Eating Pattern to Limit Malnutrition in Older Adults
The SENIOR STUDY is aimed at improving the condition of older adults and malnutrition management in and out Italian hospital settings, since malnutrition is highly prevalent, clinically relevant and potentially treatable…
- Trial name
- SENIOR (NCT05860556)
- Where
- Italy
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Sarcopenia, Pseudoexfoliation Syndrome
Pseudoexfoliation Syndrome, Sarcopenia and Chronic Pain
Aim: Pseudoexfoliation syndrome (PEX) is a systemic disease of connective tissue, it can also contribute to sarcopenia and chronic musculoskeletal pain with common pathways. 1.
- Trial name
- NCT06121154
- Testing
- SARC-F questionnaire, Gait speed, The chair rise test
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Sarcopenia
Fish Protein Supplementation and Sarcopenia Outcomes in the Community
Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increase adverse outcomes including falls, functional decline, frailty and…
- Trial name
- SARCO_COMM (NCT05356559)
- Testing
- Intervention, Control
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Heart Failure, Sarcopenia
The Sarcopenia Study
The goal of this cross-sectional study is to investigate the prevalence of sarcopenia in patients with Heart Failure. The main question it aims to answer is: Whether there is a difference in the prevalence of sarcopenia across…
- Conditions
- Heart Failure, Sarcopenia, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05888688
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Bariatric Surgery, Sarcopenia
Impact of Whey Protein Supplementation on Body Weight and Metabolic Parameters of Bariatric Patients
Obesity is a metabolic disorder, characterized by an increase in the body's fat mass, which will reflect an increase in total body weight. In Brazil, overweight accounts for 53.8% of the population, and of these 18.9% are obese.
- Trial name
- NCT04510389
- Testing
- Maltodextrin, Whey
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Sarcopenia, Pediatric Cancer
Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients
In children, both malnutrition and sarcopenia are associated with prolongation of hospital stay, increased morbidity, mortality, and health-related complications.
- Trial name
- NCT05294380
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trakya University
Sarcopenia
Omega-3 Fatty Acids to Combat Sarcopenia
The purpose of this study is to determine how omega-3 fatty acids influence muscle protein metabolism and mitochondrial physiology in the context of human aging.
- Trial name
- NCT02103842
- Testing
- Omega-3 fatty acids
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Liver Cirrhosis
Lean Mass Evaluation of Cirrhotic Patients With Ascites With the Use DXA
Malnutrition due to liver disease is common, however, their detection is difficult. The parameters used for nutritional assessment in clinical practice have limited use in this patient population.
- Trial name
- BCECPA (NCT02421848)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sarcopenia
Managing the Nutritional Needs of Older Filipino With Due Attention to Protein Nutrition and Functional Health Study
The study aims to determine the effect of protein nutrition and exercise on the body composition and functional capacity of Filipino older adults.
- Trial name
- ManoPo (NCT05953116)
- Testing
- Nutrition supplementation, Exercise
- Where
- Philippines
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Food and Nutrition Research Institute, Philippines
Muscle Weakness, Muscle Loss
A Study on the Effects on Glucose Regulation, Inflammation and Serum Lipids After Fish Protein Supplementation in Elderly (GRIPE)
The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population.
- Conditions
- Muscle Weakness, Muscle Loss, Blood Sugar; High, Inflammation
- Trial name
- GRIPE (NCT03529344)
- Testing
- Blue whiting protein hydrolysate
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Geriatric, Sarcopenia
Investigation of Respiratory Muscle Sarcopenia in Geriatric Individuals
The increase in the elderly population worldwide necessitates further research on age-related physiological changes and health problems related to these changes in geriatric individuals.
- Conditions
- Geriatric, Sarcopenia, Diaphragm
- Trial name
- NCT06994598
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Muscle Atrophy, Surgery
Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
The loss of muscle mass post-surgery confounds recovery efforts and leads to a delay in patient's ability to return to activities.
- Conditions
- Muscle Atrophy, Surgery, Knee Injuries and Disorders, Complication of Surgical Procedure
- Trial name
- NCT04456530
- Testing
- Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Stone Research Foundation for Sports Medicine and Arthritis
Surgery
Peanut Protein Supplementation to Prevent Muscle Atrophy and Improve Recovery Following Total Knee Arthroplasty
This randomized controlled trial will study the effects of peanut protein supplementation on changes in muscle size and quality in patients undergoing total knee arthroplasty.
- Trial name
- NCT04294563
- Testing
- Peanut Protein Powder, Standard Care by Surgeon and Physical Therapist
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Auburn University