Clinical trials: Muscle Wasting
Femoral Neck Fractures, Pertrochanteric Fracture
Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures
The aim of this clinical trial is to compare serum concentration of bone intake proteins [ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)] and muscle atrophy marker [creatine kinase…
- Conditions
- Femoral Neck Fractures, Pertrochanteric Fracture, Bone Resorption, Bone Loss
- Trial name
- NCT05804604
- Testing
- Surgical treatment of proximal femur fracture and blood sample test, Blood sample test
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Aging, Vascular Endothelium
Vascular Dysfunction During Physical Inactivity
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to a sedentary lifestyle or acute hospitalization is also associated with impaired recovery…
- Conditions
- Aging, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04872998
- Testing
- Step Count Reduction
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Utah
Atrial Fibrillation, Frail Elderly Syndrome
The Relationship Between Atrial Fibrillation and Frailty in Community-Dwelling Elderly
Atrial fibrillation (AF) is the most common arrhythmias in clinical practice. Research investigating hospitalized patients have indicated there are deleterious effects of AF on patients besides the disease burden itself…
- Trial name
- NCT03420326
- Testing
- Frailty status assessment
- Where
- Taiwan
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Disk Herniated Lumbar
Muscle Analyze In Patient With Disc Herniation
This study which was planned to investigate the factors affecting m. erector spinae (ES), m. multifidus (MF), m. psoas major (PM) and m. quadratus lumborum (QL), which stabilize the lumbar region in the case of disc herniation.
- Trial name
- NCT05245214
- Testing
- Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Advanced Lung Cancer, Sarcopenia
Differences in Rate of Decline in CT-defined Skeletal Muscle Mass and Physical Performance in Patients With Advanced Non-small Cell Lung Cancer Receiving Chemotherapy and Targeted Therapy/Immunotherapy, Before and After Treatment.
Lung cancer is a common disease leading to 18 % of cancer deaths worldwide. Despite various improvement in treatment, there still remains low 5-year survival rate of 10-20 % in advanced lung cancer patients.
- Trial name
- NCT06326086
- Testing
- Chemotherapy drug, Targeted Agent, Immunotherapy
- Where
- Thailand
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Sarcopenia
Protein Synthesis in Midthigh Muscles PET/CT
The purpose of this study is to test a new imaging technique to help scientists study sarcopenia, the process by which muscle becomes weaker with age.
- Trial name
- NCT01008839
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Frailty, Sarcopenia
A Randomized Control Trial of an Intervention to Reverse Frailty and Enhance Resilience Through Exercise and Education
Resistance training done at home and protein supplementation may be the most effective and easiest to implement interventions to reverse frailty and build resilience.
- Trial name
- REFEREE (NCT04628754)
- Testing
- Exercise and protein
- Where
- Ireland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Sarcopenia, Inflammation
Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly
Sarcopenia, which refers to the progressive loss of skeletal muscle mass and strength, shares many characteristics with other disease states typically associated with risks of falling and fracture, including osteoporosis…
- Conditions
- Sarcopenia, Inflammation, Aging
- Trial name
- NCT04985877
- Testing
- Yakult 300 LIGHT Fermented Milk
- Where
- 3 sites in Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Aging, Muscle Strength
Get in Shape in the Team Research: Porukalla Kuntoon Tutkimus
It is well accepted that physical activity in the form of resistance training produces a wide variety of neuromuscular-skeletal and health benefits.
- Trial name
- PoKu (NCT02413112)
- Testing
- Resistance training
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Jyvaskyla
Sarcopenia, Ultrasound
Assessment System for Sarcopenia Based on Ultrasonographic Data
1. To develop an artificial intelligence assisted diagnostic model for sarcopenia based on ultrasound images; 2. To develop artificial intelligence classification and regression models for auxiliary diagnosis of sarcopenia…
- Trial name
- NCT06199856
- Testing
- ultrasound scan
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Aging, Sarcopenia
PANGeA - Physical Activity and Nutrition for Quality Ageing
General objectives of the project Defining healthy ageing factors; Setting up content-related bases of the international excellence centre (SLO-ITA) in the field of health of elderly citizens; Raising awareness on the…
- Conditions
- Aging, Sarcopenia, Cognitive Decline
- Trial name
- PANGeA_MM (NCT04899531)
- Testing
- Longitudinal observation
- Where
- Slovenia
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Science and Research Centre Koper
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Sarcopenia
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle
The age-related loss of muscle mass and strength, also termed sarcopenia, is a commonly recognized consequence of aging and has been associated with frailty, functional loss, hospitalization, and increased mortality among older…
- Trial name
- NCT01644279
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Sarcopenia
Dietary Nitrate and Muscle Power With Aging
The purpose of this study is to see if drinking beetroot juice (BRJ) is beneficial for aging patients. We hope to determine the effect of BRJ on exercise performance.
- Trial name
- NCT03513302
- Testing
- nitrate
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscle Loss
Preservation of Fat Free Mass During Weight Loss
In this study, we aimed to examine the effect of whey protein supplementation given before night sleep on Fat Free Mass (FFM) preservation during a 4 wk period on Very Low Caloric Diet (VLCD).
- Trial name
- NCT03102372
- Testing
- Whey protein supplementation, walking program, Very Low Calorie Diet
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sarcopenia, Functional Decline
Impact of Acute Hospitalisation and Resistance Training on Muscle Architecture and Physical Performance in Older Adults
Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline.
- Conditions
- Sarcopenia, Functional Decline, Muscle Architecture, Gait Speed
- Trial name
- NCT05798169
- Testing
- Resistance training
- Where
- Denmark
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Mitochondrial Energetics, Dietary Nitrate
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition…
- Conditions
- Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg
- Trial name
- NCT07161973
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Digital Assessment of Speech and Fine Motor Control in ALS
This is a single-session, case-control study that incorporates digital tools for assessing speech and motor function in motor neuron disease.
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- NCT06315673
- Testing
- Digital Speech and Handwriting Assessment
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Sarcopenia
Sarcopenia Screening in Elderly Individuals
In this study, it is aimed to evaluate parameters such as sarcopenia screening, muscle mass measurement, loss of strength that may develop due to sarcopenia, loss of balance and related fall, decrease in functionality, fragility…
- Trial name
- NCT06012422
- Testing
- evaluation group
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Ageing
Study to Assess the Effect of Leucine Along With Resistance Exercise on Muscle Strength and Quality of Life in Elders
The purpose of this study is to determine whether a nutritional supplement with an amino acid called leucine along with resistance exercise are effective in the improvement of muscle strength and quality of life in elderly people.
- Trial name
- NCT00929929
- Testing
- L-leucine., Maltodextrin., Exercise program.
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona