Clinical trials: Muscle Wasting
Sarcopenia
Assessment of in Vivo Skeletal Muscle Viscoelasticity (ARFI Imaging) With Aging and Cancer
Sarcopenia is known to be associated with loss in muscle mass that results from a reduced number of muscle fibres, an atrophy of remaining muscle fibres, and an increased infiltration of non-contractile tissue (collagen, fat).
- Trial name
- CAPARFI (NCT01484821)
- Testing
- ARFI
- Where
- 2 sites in France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Sarcopenia
The Effects of Long Term Cyclic Testosterone Administration on Muscle Function and Bone in Older Men
The general hypothesis is that administration of testosterone to healthy, older men for 52 weeks (1 year) following a cycle of 4 weeks of testosterone administration and 4 weeks without testosterone (i.e., monthly cycled regimen)…
- Trial name
- NCT01417364
- Testing
- Testosterone enanthate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)
Up to 66 healthy elderly individuals (at least 65 years old) are recruited as subjects. They will be recruited as a subgroup to protocol ID: H-4-2013-070.
- Trial name
- CALM (NCT02115698)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Disk Herniated Lumbar
Muscle Analyze In Patient With Disc Herniation
This study which was planned to investigate the factors affecting m. erector spinae (ES), m. multifidus (MF), m. psoas major (PM) and m. quadratus lumborum (QL), which stabilize the lumbar region in the case of disc herniation.
- Trial name
- NCT05245214
- Testing
- Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Sarcopenia, Handgrip Strength Test
Preoperative Performance Indicators, Preoxygenation and Oxygen Reserve Relationship
The goal of this observational study is to evaluate the relationship between preoperative cardiopulmonary performance indicators and preoxygenation efficiency along with oxygen reserve depletion in patients scheduled for elective…
- Conditions
- Sarcopenia, Handgrip Strength Test, Preoxygenation
- Trial name
- NCT07688941
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis of the Knee, Sarcopenia
Identification of Sarcopenia in Knee Osteoarthritis With Ultrasonography and Evaluation of Muscle Architecture Change by Ultrasonography After Isokinetic Exercise Program
The aim of this thesis; To define sarcopenia in knee osteoarthritis with ultrasonography and to evaluate changes in muscle structure in sarcopenia after isokinetic exercise application ultrasonographically.
- Trial name
- NCT05019820
- Testing
- Knee strengthening exercises with isokinetic dynamometer, Strengthening around the knees with home exercise programe
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sema Dağcı
Sarcopenia, Denutrition
Evaluation of the SARC-F Score as a Screening Tool for Undernutrition in a Geriatric Population
To study the relationship between sarcopenia and undernutrition in adult patients over 70 years of age, and at the same time to define a threshold value for the predictive SARC-F score of undernutrition.
- Trial name
- GERIASARC (NCT03553147)
- Testing
- SARC-F score, handgrip test and impedancemetry
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Obstructive Pulmonary Disease (COPD), Muscle Atrophy
The Effect of Two Weeks of Voluntary Reduced Physical Activity in Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is the most common pulmonary disease, responsible for considerable morbidity and mortality and is the third leading cause of death worldwide.
- Trial name
- NCT02221804
- Testing
- 14 days of voluntary step count reduction to no more than 1500 steps/day.
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Sedentary Lifestyle
Effectiveness of a Physical Exercise Prescription Program in Primary Care for Adults Aged 65 and Older: PREFIS-AP
This randomized controlled trial aims to evaluate the effectiveness of an individualized Physical Exercise Prescription Program delivered in Primary Care for adults aged 65 years and older.
- Trial name
- NCT07394790
- Testing
- Physical Exercise Prescription Program
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Muscle Atrophy or Weakness, Muscle Contraction
Core Exercises Effects on Muscle Imbalances
This study aims in investigating the effects of a core muscles' strengthening program on core muscles' atrophy and contraction ability.
- Conditions
- Muscle Atrophy or Weakness, Muscle Contraction, Core Stability
- Trial name
- NCT04450615
- Testing
- Core stability
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Athanasios Ellinoudis
Neuromuscular Diseases in Children, Respiratory Function Impaired
Respiratory Functions, Thoracoabdominal Movements and Exercise Capacity in Neuromuscular Diseases
The clinical trial titled "Investigation of Respiratory Functions, Thoracoabdominal Movements, and Exercise Capacity in Neuromuscular Diseases" aims to evaluate the respiratory functions, thoracoabdominal movements, and exercise…
- Conditions
- Neuromuscular Diseases in Children, Respiratory Function Impaired, Respiratory Insufficiency, Duchenne Muscular Dystrophy
- Trial name
- NCT06756633
- Testing
- Respiratory Function Test, Structured light plethysmography, 6 Minute Walking Test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Sarcopenia
Vegan Diets: the Short-term Effects on Daily Muscle Protein Synthesis Rates as Compared to Omnivorous Diets in Older Adults Assessed by D2O.
Consumers are increasingly encouraged to consume more plant-based foods and lower their consumption of foods from animal origin. However, the consequences of such a transition on muscle mass still remains to be explored.
- Trial name
- VD2O (NCT05624333)
- Testing
- Vegan diet (intervention), Omnivorous diet (control)
- Where
- Netherlands
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Sarcopenia
Protein Intake and Exercise-induced Muscle Damage
The goal of this clinical trial is to test the effect of different protein-enhancement strategies versus carbohydrate control on exercise-induced muscle damage in physically active older adults.
- Trial name
- PROMO (NCT06235476)
- Testing
- whey protein supplement, mixed plant-based protein supplement, e-health application
- Where
- Netherlands
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Spinal Muscular Atrophy, Duchenne Muscular Dystrophy
Public AttitudesTowards SMA and DMD Awareness, Newborn and Carrier Screening and Physiotherapy Practices
The addition of SMA and DMD muscle diseases to newborn screening and premarital carrier screening has been controversial. In this study, researchers aim to measure the awareness level of SMA and DMD muscle diseases of individuals…
- Conditions
- Spinal Muscular Atrophy, Duchenne Muscular Dystrophy, Healthy Individuals
- Trial name
- NCT05110885
- Testing
- Questionnaire
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Muscular Atrophy
Timecourse of Immobilization Experiment
The effect of unilateral lower limb immobilisation over one week on muscle atrophy
- Trial name
- TIME (NCT02984332)
- Testing
- Lower limb immobilisation (leg brace)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sarcopenia
Nutrition and Exercise for Sarcopenia
The investigators' general hypothesis is that nutritional factors, including protein/energy malnutrition and/or an impaired response of muscle to nutrition, and inactivity play significant roles in developing sarcopenia, the…
- Trial name
- NCT00872911
- Testing
- Amino acids, Exercise
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Muscle Atrophy, Proximal, Muscle Atrophy
Ultrasound for Rectus Femoris Measurement
Postoperative protocols for orthopedic procedures on the lower limb often require a period of immobilization to protect the surgical site.
- Conditions
- Muscle Atrophy, Proximal, Muscle Atrophy, ACL Tear, Quadriceps Muscle Atrophy
- Trial name
- NCT04105816
- Testing
- 892.1550 Ultrasonic pulsed doppler imaging system, Thigh circumference measurement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Robert Westermann
Femoral Neck Fractures, Pertrochanteric Fracture
Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures
The aim of this clinical trial is to compare serum concentration of bone intake proteins [ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)] and muscle atrophy marker [creatine kinase…
- Conditions
- Femoral Neck Fractures, Pertrochanteric Fracture, Bone Resorption, Bone Loss
- Trial name
- NCT05804604
- Testing
- Surgical treatment of proximal femur fracture and blood sample test, Blood sample test
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Psoriatic Arthritis
Evaluation of Sarcopenia and Related Factors in Patients Diagnosed With Psoriatic Arthritis
The purpose of the study is identify the prevalence of sarcopenia and its associated factors in patients with psoriatic arthritis.
- Trial name
- NCT06437392
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent