Clinical trials: Muscle Wasting
Sarcopenia, Malnutrition
EAMA Sarcopenia in Acute Care Patients in 9+European Countries
This collaborative study in 9 geriatrics units across Europe aims to apply emerging research to clinical practice, following the "Action-Research Philosophy" (11).
- Trial name
- EAMA9+ (NCT04039620)
- Testing
- Observational study, no interventions expected
- Where
- Spain
- Volunteers
- 366 people
- Sponsor
- Parc de Salut Mar
Spinal Muscular Atrophy
Exploring the Physiologic, Pharmacodynamic, and Clinical Responses of Skeletal Muscle in Patients With Spinal Muscular Atrophy Treated With SMN-Directed Therapies
In this observational study, researchers are looking at the effects of spinal muscular atrophy (SMA) drugs on the muscles and nerve cells in patients with SMA.
- Trial name
- NCT06532474
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- St. Jude Children's Research Hospital
Hip Fractures, Sarcopenia
Feasibility of High Density Sit-to-stand Functional Resistance Training in Patients With Hip Fracture
The objective of this study is to examine if functional high-density, high-volume chair rise training is feasible for increasing lower extremity strength without causing excessive hip pain during execution in patients with hip…
- Conditions
- Hip Fractures, Sarcopenia, Fall Injury
- Trial name
- NCT05840315
- Testing
- Basic intervention and nutritional intervention, Sit-to-stand, Leg press
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Horsholm Municipality
Sarcopenia
The Whole Body Vibration for Sarcopenic Hospitalized Patients Aged 80+ Years
Resistance training have been recommended for sarcopenic patients. However, the whole body vibration training would further benefit for sarcopenic patients on the basis of resistance training remains unclear.
- Trial name
- NCT04637789
- Testing
- the whole body vibration, resistance training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yuxiang Liang
Sarcopenia
Determining the Muscle Anabolic Properties of Phosphatidic Acid.
Ageing is characterized by a loss of muscle mass that is detrimental for physical function and metabolic health and increases the risk of mortality.
- Trial name
- PA-AGE (NCT03446924)
- Testing
- Phosphatidic Acid, Rice flour
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscular Atrophy, Spinal
Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular Atrophy
Open-label, multi-center clinical study is to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamics (PD), and efficacy of Risdiplam (RO7034067) in infants with Type 1 spinal muscular atrophy (SMA).
- Trial name
- FIREFISH (NCT02913482)
- Testing
- Risdiplam
- Where
- 32 sites in United States, Belgium and 14 more
- Volunteers
- 62 people
- Sponsor
- Hoffmann-La Roche
Spinal Muscular Atrophy, Neuromuscular Disorders
Study of Feasibility to Reliably Measure Functional Abilities' Changes in Nonambulant Neuromuscular Patients Without Trial Site Visiting
Clinical trials organization in several neuromuscular disorders (NMD) has some specific issues. Nonambulant status and difficulties with transportation are among them.
- Trial name
- NCT02235090
- Testing
- Direct current stimulation of cervical spinal cord
- Where
- Ukraine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Charitable Foundation Children with Spinal Muscular Atrophy
Sarcopenia
The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals
The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors are affected by strength…
- Trial name
- NCT03326648
- Testing
- Strength training, Protein supplementation
- Where
- Norway
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Truls Raastad
Trauma, Nutritional Deficiency
Trauma Screening and Supplementation
The purpose of the proposed study is twofold: 1) The investigators will evaluate ultrasound imaging to screen trauma patients to identify patients at increased risk of postoperative complications associated with sarcopenia.
- Conditions
- Trauma, Nutritional Deficiency, Wound Heal
- Trial name
- NCT03658278
- Testing
- Juven
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Michael C Willey
Sarcopenia
Assessing the Efficacy of a Muscle Strength Training Intervention for Sarcopenia in Middle-aged and Elderly Individuals
Taiwan entered an aging society in 2018 and is projected to become a super-aged society by 2025. With the increasing elderly population, age-related diseases have become an urgent issue in modern society.
- Trial name
- NCT07554274
- Testing
- Resistance exercise
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Community-Based Participatory Research, Aged
Associations Between Self-Reported Sleep Duration and Sarcopenia in Community-Dwelling Older Adults
1. BACKGROUNDS: Currently, elderly people comprise more than 10% of the total Taiwanese population. However, within the context of self-reported sleep duration and health risks, research into the association between sleep…
- Conditions
- Community-Based Participatory Research, Aged, Sleep, Body Composition
- Trial name
- NCT02126410
- Where
- Taiwan
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Breast Neoplasms, Sarcopenia
Facility-Based Multi-Modal Rehab vs. Home-Based Resistance Exercise for Quality of Life in Breast Cancer Survivors
This study evaluates the comparative effectiveness of a multi-modal facility-based rehabilitation program (therapist-led resistance exercise and relaxation training) versus a self-directed home-based resistance exercise program…
- Trial name
- exercise (NCT07465393)
- Testing
- Multimodal Resistance and Relaxation Training, Home-Based Resistance Exercise Training
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Valeria Chiu
Cerebral Palsy, Spinal Muscular Atrophy
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study
For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position.
- Conditions
- Cerebral Palsy, Spinal Muscular Atrophy, Spinal Cord Injuries, Spina Bifida
- Trial name
- NCT05117827
- Testing
- Power Wheelchair Standing Device
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Aging, Sarcopenia
Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults
This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.
- Trial name
- NCT04015479
- Testing
- Peanut Protein Powder, Full body resistance training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Auburn University
Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type III
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
The purpose of this study is to identify the maximum tolerated dosage of sodium phenylbutyrate in children with spinal muscular atrophy types II or III; and to determine if the drug has an effect on SMN mRNA and protein levels.
- Trial name
- NPTUNE01 (NCT00439569)
- Testing
- sodium phenylbutyrate
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- Westat
Colorectal Cancer, Exercise, Aerobic
Pedaling at a Low-Moderate Intensity During Chemotherapy Administration
The purpose of this study is to evaluate the feasibility of completing a low-moderate intensity pedaling session concurrent to chemotherapy treatment for colorectal cancer.
- Conditions
- Colorectal Cancer, Exercise, Aerobic, Chemotherapy, Chemotherapeutic Toxicity
- Trial name
- NCT04258969
- Testing
- Pedaling
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
ICU Acquired Weakness
Evaluation of FDY-5301 in Major Trauma Patients in ICU
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of FDY-5301 compared to placebo in major trauma ICU patients at risk of intensive care unit acquired weakness (ICUAW)
- Trial name
- NCT04430283
- Testing
- FDY-5301
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
Sarcopenia, Muscle Weakness
Effects of Mobility Dose in Surgical Intensive Care Unit Patients
The primary aim of this study is to assess if the mobility dose that patients receive in the surgical intensive care unit (SICU) predicts adverse discharge disposition (primary endpoint), and muscle wasting diagnosed by bedside…
- Conditions
- Sarcopenia, Muscle Weakness, Critical Illness
- Trial name
- MQS (NCT03196960)
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Aging, Foot Muscle Dysfunction
Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults
This study is designed as a randomized controlled trial. A total of 40 healthy older adults residing in private and public nursing homes and rehabilitation centers in Mersin will be enrolled.
- Conditions
- Aging, Foot Muscle Dysfunction, Sarcopenia, Age-Related Muscle Weakness
- Trial name
- EXG-FOOT (NCT07357662)
- Testing
- Exergame-based Balance and Foot Muscle Training, Conventional Functional Balance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tarsus University
Prostate Cancer, Radiotherapy Side Effect
PROstate CAncer Radiotherapy - Bowel Quality of Life (PROCAR-BQ)
This is a prospective pilot study to evaluate the mean increase of bowel symptoms after pelvic radiotherapy (RT) in prostate cancer (PCa) patient using the validated \& newly translated EORTC-QLQ PRT20 module.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Bowel Dysfunction, Quality of Life
- Trial name
- PROCAR-BQ (NCT05880446)
- Testing
- Bowel symptoms & QoL assessment
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Jules Bordet Institute