Clinical trials: Muscle Weakness
Musculoskeletal Status, Muscle Weakness
Use of Jumping Mechanography as a Method to Assess Musculoskeletal Status in Older Adults
Decline in muscle function may increase risk of hip fracture and decrease quality of life. Different tests are currently used to measure muscle function but they do not work for all individuals.
- Trial name
- NCT00596089
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Intensive Care Unit Acquired Weakness
The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
In this study, the effect of inspiratory muscle training on diaphragmatic functions will be investigated radiologically in mechanically ventilated patients.
- Trial name
- NCT05303623
- Testing
- Conventional Physiotherapy, Conventional Physiotherapy+ inspiratory muscle training, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Aging, Muscle Atrophy or Weakness
C-Protein in Fatigue and Aging
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
- Conditions
- Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly, Sarcopenia
- Trial name
- NCT05926219
- Testing
- Fatiguing Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Frailty Syndrome, Geriatric Health
Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Geriatric Health, Respiratory Muscle Weakness, Age-Related Frailty
- Trial name
- NCT07556445
- Testing
- Inspiratory Muscle Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Primary Lateral Sclerosis, Hereditary Spastic Paraplegia
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy (H-MRS) to define the pathology and progression of primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral…
- Conditions
- Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Amyotrophic Lateral Sclerosis
- Trial name
- NCT00023075
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sarcopenia, Aging
Reducing Falls With Progressive Resistance Training for the Oldest Old Adults With Reduced Muscle Strength
This study will investigate the effects of 12 months of high-intensity progressive resistance training compared with a control group on fall-rate in older adults with reduced muscle strength.
- Trial name
- ReFit (NCT05691166)
- Testing
- High-intensity progressive resistance training, Written physical activity guidance
- Where
- Norway
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Stroke, Hemiparesis
Trans Auricular Vagus Nerve Stimulation (taVNS) and Robotic Training for Paralyzed Arm After Stroke
To determine whether treatment with transauricular vagus nerve stimulation (taVNS) during the training of an affected upper limb of a patient with chronic stroke on a robotic motor task alters the motor impairment.
- Trial name
- VaNSaRTS (NCT05339893)
- Testing
- In Motion Rehabilitation Robot
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Hemiparesis
Investigation of the Spatio-temporal Gait Parameters in Individuals With Hemiparesis: Effect of Lateralization
The aim of this study was to investigate the effect of lateralization on the spatio-temporal characteristics of gait in individuals with hemiparesis.
- Trial name
- NCT04672057
- Testing
- assessment of gait parameters
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Stroke, Biofeedback
Biofeedback Gait Training by Target Biomechanical Parameters in the Early Recovery Period of Stroke
Single-blinded controlled clinical trial. Biofeedback training courses based on target biomechanical gait parameters are being studied.
- Conditions
- Stroke, Biofeedback, Gait, Hemiplegic, Gait Training
- Trial name
- TargetGait (NCT06299943)
- Testing
- Biofeedback gait training by biomechanical target parameter
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Heart Failure
Exercise Capacity and Fatigue in Heart Failure Patients With and Without Inspiratory Muscle Weakness
In patients with heart failure, diaphragm dysfunction contributes to decreased quality of life while simultaneously increasing morbidity and mortality.
- Trial name
- NCT06428227
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Gazi University
Weak; Pelvic Floor, Weak; Muscle
Effect of the Pelvic Floor Training in Postmenopausal Women With or Without Hormonal Therapy
The purpose of this study is to evaluate the effect of pelvic floor muscle training (PFMT) on muscle function of postmenopausal women using or not using hormonal therapy replacement (HTR).
- Conditions
- Weak; Pelvic Floor, Weak; Muscle, Urinary Incontinence
- Trial name
- NCT02549729
- Testing
- pelvic floor muscle training
- Where
- Brazil
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Arthritis, Rheumatoid, Muscular Weakness
Neuromusuclar Adaptations in the Rheumatoid Arthritis Disease
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation and progressive joint destruction. Rheumatoid cachexia is one of the structural manifestations of RA, and consists of a reduction in muscle…
- Trial name
- NCT03543488
- Testing
- Neuromuscular and functional capacity tests
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Metastatic Cancer, Cachexia; Cancer
Cancer-Associated Muscle Atrophy and Weakness: An Investigation of Etiology
This study is designed to gain a better understanding of the mechanisms leading to muscle wasting and metabolic abnormalities in skeletal muscle of cancer patients.
- Trial name
- NCT03012139
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Stroke, Hemiparesis
Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke
The purpose of this study is: 1. To augment the MAHI Exo-II, a physical human exoskeleton, with a non-invasive brain machine interface (BMI) to actively include patient in the control loop and thereby making the therapy 'active'.
- Trial name
- NCT01948739
- Testing
- MAHI EXO-II exoskeleton augmented with BMI system
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Nutrition, Healthy, Muscle Weakness
A Randomized Control Trial of Hinex Jelly on the Changes in Muscle Quality and Quantity
Taiwan is about to enter a super-aged society in 2025. The health problems of the elderly are getting more and more attention. Among these geriatric issues, sarcopenia is an important issue.
- Conditions
- Nutrition, Healthy, Muscle Weakness, Elderly
- Trial name
- NCT05917353
- Testing
- Hinex Jelly
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Diabetic Foot Ulcer, Diabetic Wound
Peer Support for Patients With Diabetic Foot Ulcers
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation…
- Conditions
- Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot
- Trial name
- NCT06004219
- Testing
- Peer counseling group
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Stroke, Hemiparesis
Error Enhancement of the Velocity Component
The purpose of this pilot study was to explore the impact of enhancement of the velocity component error in the course of reaching movements of the impaired/hemiparetic limb in an acute stroke subject.
- Trial name
- NCT02017093
- Testing
- Error Enhancement, control treatment
- Where
- Israel
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Physical Endurance, Hypermobility, Joint
Lateral Neck Flexor Endurance and Hyperlaxity
The lateral neck flexor endurance test has been proposed to assess for unilateral muscular deficits. It is not known if individuals with hyperlaxity have different muscular endurance than individuals without hyperlaxity.
- Conditions
- Physical Endurance, Hypermobility, Joint, Muscular Weakness
- Trial name
- NCT04770987
- Testing
- lateral neck flexor endurance test
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Hartford
Frail Elderly Syndrome
Protocols and Guidelines for the Use of Digital Twins in Frail Older People
The Proto-Aging study aims to define experimental protocols and guidelines to enable the development of musculoskeletal models (digital twins) of elderly people, with the ultimate goal to comprehensively characterize frail elders…
- Trial name
- Proto-Aging (NCT05854316)
- Testing
- Comprehensive Biomechanical assessment
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Chemotherapy-induced Peripheral Neuropathy (CIPN), Healthy
Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Great Toe Strength (GTS) is a potential clinical biomarker that has been associated with functional mobility and health; Additionally, GTS has been identified in the literature as one of the early symptoms of chemotherapy-induced…
- Trial name
- NCT07009717
- Testing
- No intervention (observational study)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida