Clinical trials: Muscular Disorders, Atrophic
Androgen Receptor Abnormal, Endometrial Disorder
The Effect of Androgen Receptor Polymorphism on Endometrial Cancer
Endometrial tissue is a hormonal-dependent tissue in both pre- and postmenopausal period. The endometrial cells are expressing receptors for all sex hormones, mainly for estrogen, progesterone and androgens.
- Trial name
- AREC (NCT05157373)
- Testing
- Endometrial sampling and Peripheral blood collection, FSFI Scale
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Muscle Injury, Muscle Atrophy
Ultrasound Measurements Hamstring Muscles Thickness
No previous studies have compared the association between muscle thickness (MT) and muscle cross-sectional area (CSA) in healthy volunteers.
- Trial name
- NCT02958254
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Valencia
Becker Muscular Dystrophy, McArdle Disease
Fast Troponin as a Biomarker to Assess Exercise-induced Muscle Damage in Muscle Diseases
The purpose of the study is to explore the biomarker Fast Troponins response to exercise in patients with Becker muscular dystrophy, Limb-girdle muscular dystrophy and McArdle disease
- Conditions
- Becker Muscular Dystrophy, McArdle Disease, Limb-Girdle Muscular Dystrophy Type 2
- Trial name
- NCT04349566
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mads Peter Godtfeldt Stemmerik
Sarcopenia
Postprandial Muscle Protein Synthesis Following Wheat Protein Ingestion in Vivo in Humans
Rationale: The progressive loss of skeletal muscle mass with aging, or sarcopenia, has a major impact on our health care system due to increased morbidity and greater need for hospitalization and/or institutionalization.
- Trial name
- NCT01952639
- Testing
- protein type and amount
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia, Osteoarthritis
The Presence Of Sarcopenia In Patients With Knee Osteoarthritis
Osteoarthritis (OA) is one of the most common joint disorders worldwide . The knee is the most common symptomatic joint in osteoarthritis.
- Trial name
- NCT04828200
- Testing
- Musculoskeletal ultrasound, Dual-X-ray absorptiometry, Isokinetic dynamometer
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Primary Sjögren Syndrome, Sarcopenia
Possible Sarcopenia, Sarcopenia, and Functional Status in Patients With Primary Sjögren's Syndrome
The aim of this study is to evaluate the frequency of probable sarcopenia and sarcopenia in patients with primary Sjögren syndrome and to investigate the effects of sarcopenia on functional status, muscle strength, and quality of…
- Trial name
- NCT07804719
- Testing
- dexa, hand grip strength, myostatin, follistatin
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Sarcopenia, Spinal Disease
Spinal Sarcopenia Cohort Study (SarcoSpine)
Sarcopenia on lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there are few studies on the precise concept and diagnostic criteria for spinal sarcopenia.
- Trial name
- SarcoSpine (NCT03962530)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Osteoporosis, Sarcopenia
The Effect of 6 Months of Local Vibration Training in Institutionalized Elderly
This randomized controlled intervention study in institutionalized elderly investigates the effect of 6 months of local vibration therapy applied on the thigh and hip on muscle strength, muscle mass, bone density, and…
- Trial name
- NCT01499186
- Testing
- Local Vibration
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity, Sarcopenia
Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle
Obesity in humans has been shown to result in the increased release of small inflammatory-inducing proteins, called cytokines, from the fat cells of the body.
- Trial name
- NCT02305069
- Testing
- Pioglitazone, Insulin, Octreotide
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Muscle Ageing Sarcopenia Study Lifecourse (MASS Lifecourse)
Sarcopenia is the loss of muscle mass and function with age. It has been recognised as an important health problem because it is common in older adults and associated with decline in physical function as well as a reduced quality…
- Trial name
- MASS_LC (NCT04239495)
- Testing
- Observational study: range of clinical and lifestyle factors
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Sarcopenia, Obesity
Citrulline Supplementation Combined With Exercise: Effect on Muscle Function in Elderly People (CITEX Study)
The main objective of this study is to determine if oral supplementation of Citrulline, when combined with HIIT, can produce significant changes in body composition, muscle quality, muscle metabolism and functional capacity in…
- Trial name
- CITEX (NCT02417428)
- Testing
- Citrulline, Exercise, without exercise
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Sarcopenia, Liver Cirrhosis
Microbiome and Sarcopenia in Patients With Liver Cirrhosis
Protein-energy malnutrition (PEM) occurs in 65-90% of patients with liver cirrhosis. Severity of malnutrition correlates with progression of liver disease and leads to sarcopenia in 30-70% of cirrhotic patients.
- Trial name
- NCT03080129
- Testing
- Fresubin energy
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Muscle Adaptation, Body Composition
Creatine and Muscle Health in Madrid's Walking Footballers.
Healthy aging requires effective, accessible, and sustainable interventions capable of preserving functional capacity and preventing age-related decline.
- Conditions
- Muscle Adaptation, Body Composition, Physical Activity in Adults
- Trial name
- MyoCreaWalk (NCT07891936)
- Testing
- Monohydrate Creatine supplementation during Walking Football training
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Sarcopenia
Human Irisin Concentration in Sarcopenia
Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, the researches investigated whether serum irisin levels are decreased in patients with…
- Trial name
- NCT01874912
- Where
- South Korea
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Korea University
Muscular Atrophy, Spinal
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function
This is a multi-center, open-label, non-randomized, parallel-group, 2-part study to evaluate the effect of hepatic impairment on the PK and safety and tolerability of a single oral dose of risdiplam compared to matched healthy…
- Trial name
- NCT03920865
- Testing
- Risdiplam
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Protein Deficiency, Training Group, Sensitivity
Effects of a Recovery Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing
The investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.
- Conditions
- Protein Deficiency, Training Group, Sensitivity, Fatigue, Muscular Atrophy
- Trial name
- NCT05769101
- Testing
- Ingestion of a Post-Workout Supplement, Ingestion of a Maltodextrin Supplement
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joel Puente
Sarcopenia, Aging
Semi-Recumbent Vibration Therapy in Older Adults
This proposed prospective study will evaluate whether a novel exercise approach, seated vibration therapy, can improve function in the target population of older adults.
- Trial name
- NCT02533063
- Testing
- VibeTech One
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sedentary Behavior, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity in Young and Older Adults at Different Activity Levels
Recent work in the investigators laboratory has examined the ability of a non-invasive 13CO2 breath-test to assess differences in amino acid oxidation rates and net balance in young healthy males following protein feeding and…
- Conditions
- Sedentary Behavior, Aging, Sarcopenia, Amino Acids
- Trial name
- ARBT (NCT05216809)
- Testing
- Habitual Physical Activity, Step-Reduction
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sarcopenia
Magnesium Supplementation as a Nutritional Intervention in Sarcopenia
Sarcopenia is a progressive condition common in older adults and is characterized by loss of muscle strength, muscle mass, and physical performance.
- Trial name
- SARCOMAG (NCT07567963)
- Testing
- Citrate Magnesium Supplementation
- Where
- Portugal
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Saúde - Universidade do Algarve
Seniors, Old Age
Mental Effort During Low Load Resistance Training in Older Adults
The goal of this clinical trial is to determine the effect of maximal mental effort combined with low-intensity resistance training on strength and neuromuscular function in older adults.
- Conditions
- Seniors, Old Age, Sarcopenia
- Trial name
- NCT07687316
- Testing
- Low Intensity Resistance Training with Maximal Mental Effort, Low Intensity Resistance Training
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kennesaw State University