Clinical trials: Muscular Disorders, Atrophic
Sarcopenia
Fish Protein Supplementation and Sarcopenia Outcomes in the Community
Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increase adverse outcomes including falls, functional decline, frailty and…
- Trial name
- SARCO_COMM (NCT05356559)
- Testing
- Intervention, Control
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Sarcopenia, Muscle Weakness
SARCOPEDIA - Sarcopenia Diagnostics in Aging Medicine
Musculoskeletal aging is one of the major responsibilities and challenges for public health. In particular, sarcopenia correlates with an increased risk of falls and increased morbidity and mortality.
- Conditions
- Sarcopenia, Muscle Weakness, Frailty
- Trial name
- SARCOPEDIA (NCT05263596)
- Testing
- dual x-ray absorptiometry, body impedance analysis, muscle strength measurements, ultrasound
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Stroke
Effects of HIIT on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.
To determine the effects of High-Intensity Interval Training on muscle strength, atrophy, and aerobic capacity in stroke patients.
- Trial name
- NCT06292442
- Testing
- traditional physical therapy, High intensity interval training
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sarcopenia, Pseudoexfoliation Syndrome
Pseudoexfoliation Syndrome, Sarcopenia and Chronic Pain
Aim: Pseudoexfoliation syndrome (PEX) is a systemic disease of connective tissue, it can also contribute to sarcopenia and chronic musculoskeletal pain with common pathways. 1.
- Trial name
- NCT06121154
- Testing
- SARC-F questionnaire, Gait speed, The chair rise test
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Sarcopenia in Elderly
Muscle Strength Asymmetry In Sarkopenic And Non-sarcopenic Older Adults
The purpose of this observational study is to examine whether differences in muscle strength between the dominant and non-dominant sides of the body are associated with sarcopenia in older adults.
- Trial name
- NCT07414888
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Duchenne Muscular Dystrophy
PDE Inhibitors in DMD Study (Acute Dosing Study)
PDE5A inhibition, which boosts NO-cGMP signaling, will relieve functional muscle ischemia and restore normal blood flow regulation (i.e., functional sympatholysis) during exercise in boys with DMD.
- Trial name
- NCT01580501
- Testing
- Tadalafil and Sildenafil
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Sarcopenia, Old Age; Debility
Study of the Validity and Reliability of Two Digital Dynamometers in Older People
It is a cross-sectional, randomized, and single-center study with a duration of 6 months. The study will follow the STROBE guidelines for cross-sectional studies and CONSORT 2024.
- Conditions
- Sarcopenia, Old Age; Debility, Frailty
- Trial name
- SOVARDDIOP (NCT06623019)
- Testing
- Validation and reliability
- Where
- Spain
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Inactivity, Physical, Aging
Impact of Postprandial 'Exercise Snacks' on Protein and Glucose Metabolism Following a Period of Step Reduction in Older Adults
The purpose of this study is to assess the impact of 3-days reduced physical activity (<1500 steps/day) with/without 'exercise snacks' (15 chair stands with calf raises every 30 min) on skeletal muscle metabolic health.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Sarcopenia
- Trial name
- NCT05810272
- Testing
- Metabolic Trial, 15 sit-to-stands with calf raises
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sarcopenia
Diagnostic Evaluation of Sarcopenia in Elderly Patients
Sarcopenia is a generalized progressive skeletal muscle disorder that represents a related physiological vulnerability that is associated with or increases the likelihood of adverse outcomes, including falls, fractures, physical…
- Trial name
- NCT04451005
- Testing
- 0
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Sarcopenia
Nutritional Supplementation in the Elderly With Weight Loss
Many elderly experience weight loss and weakness with normal aging. Although there is extensive literature regarding nutritional advice for the elderly, there are few well- designed studies evaluating the effect of oral nutrition…
- Trial name
- Elderly (NCT04350762)
- Testing
- Protein shake + Fish Oil
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sarcopenia
Muscle Capillarization and Sarcopenia
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders.
- Trial name
- NCT03984994
- Testing
- Aerobic exercise training, Strength training
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Pre-sarcopenia, Old Age; Debility
Effectiveness of Power Training in Older Women With Pre-sarcopenia
This is a randomized, parallel, double-blind clinical trial. The main objective is to compare the efficacy of resistance training based on power training, multimodal exercise with non-specific exercises and a control group on…
- Trial name
- POSARC (NCT05870046)
- Testing
- Power training in women older than 65 years with pre-sarcopenia, Multimodal and nonspecific exercises in women older than 65 years with pre-sarcopenia
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD
Longitudinal prospective observational study. This is a 24-month study with the possibility of extending the data time points. Initially baseline, then 12 and 24 months follow up studies will be completed.
- Trial name
- NCT02972580
- Testing
- Genetic characterization
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Sarcopenia
Muscle Ultrasound for Sarcopenia Leading to Early Detection
Sarcopenia is an age-related loss of muscle mass that may affect over 25% of individuals over the age of 60 and results in a 3 to 4 times increased likelihood of developing a disability.
- Trial name
- MUSCLED (NCT02319850)
- Testing
- DXA scanning
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- George Washington University
Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI)
Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders
The primary aim of this observational study is to investigate specific aspects of social cognition in dystrophinopathies. Body awareness, interpersonal distance and emotional processing will be measured in a sample of patients…
- Conditions
- Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI), Social Cognition
- Trial name
- NCT06874166
- Testing
- Electroencephalography (EEG), Social Cognition Tasks
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Spinal Muscular Atrophy, Neuromuscular Disorders
Study of Feasibility to Reliably Measure Functional Abilities' Changes in Nonambulant Neuromuscular Patients Without Trial Site Visiting
Clinical trials organization in several neuromuscular disorders (NMD) has some specific issues. Nonambulant status and difficulties with transportation are among them.
- Trial name
- NCT02235090
- Testing
- Direct current stimulation of cervical spinal cord
- Where
- Ukraine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Charitable Foundation Children with Spinal Muscular Atrophy
Sarcopenia, Frailty
Muscle Biopsies in Healthy Volunteers
Background: In individuals as they age, changes in muscle tissue can significantly affect their muscle strength and exercise endurance.
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT01431677
- Testing
- Muscle Biopsy
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Public Health, Sarcopenia
Appendicular Skeletal Muscle Mass Study
There is a lot of discussion concerning the normal cut-off points of skeletal mass among different populations worldwide. Genetic and environmental differences most probably lead to different measurements.
- Trial name
- SmmS (NCT04584944)
- Testing
- Dual energy X-ray absorptiometry
- Where
- Greece
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Henry Dunant Hospital Center
Sarcopenia
Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect…
- Trial name
- NCT01477164
- Testing
- High intensity aerobic exercise, Resistance exercise training, Combined
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic