Clinical trials: Muscular Disorders, Atrophic
Sarcopenia
Intervention Assessing the Role of Exercise Program and Nutrition Supplement for Sarcopenia
Sarcopenia represents the loss of skeletal muscle and strength that occurs with aging. It is a major component of frailty and its effect on daily functioning, falls, and fractures has been well documented.
- Trial name
- NCT02374268
- Testing
- Exercise program alone, Combined exercise program and nutrition supplement, Waitlist control group
- Where
- China
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sarcopenia
Exercise Protocols in Postural Balance Of Elderly Women
To determine and compare the effects of a training program with Pilates and Facilitation Neuromuscular Proprioceptive on balance and function in elderly women.
- Trial name
- NCT02278731
- Testing
- training program
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do PiauÍ
Sarcopenia
The Importance of Additional Protein to Benefit More From Training During and After Hospitalization
The purpose of the study is to investigate if an increased protein intake, in the form of a protein-enriched, milk-based supplement, can enhance the beneficial effect of resistance training, offered during hospitalization and 12…
- Trial name
- PEPOP (NCT02717819)
- Testing
- Protein, Resistance training, Vitamin D
- Where
- 3 sites in Denmark
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Forskningsenheden
Muscle Weakness, Muscle Atrophy
Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function
Neuromuscular electrical stimulation (NMES) has recently been combined with blood flow restriction (BFR) in controlled trials and has shown increased muscular strength and size compared with NMES and BFR on their own.
- Trial name
- NCT03662555
- Testing
- Neuromuscular electrical stimulation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Sarcopenia
HIF-1α Stabilization As a Novel Therapeutical Approach for Sarcopenia.
Age-related sarcopenia is associated with reduced mobility, functional decline and disability, falls, and mortality in the elderly.
- Trial name
- HIF2 (NCT06736249)
- Testing
- Sarcopenic group, Muscle harvesting
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Sarcopenia, Muscle Atrophy
Vitamin D and Resistance Exercise Training; Effects on Musculoskeletal Health in Frail Older Men and Women
This study aims to determine whether vitamin D3 supplementation is any more effective in improving musculoskeletal function when combined with exercise training compared with exercise training alone.
- Conditions
- Sarcopenia, Muscle Atrophy, Osteoporosis
- Trial name
- EXVITD (NCT02467153)
- Testing
- RET, Vitamin D3
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscle Atrophy, Myotonia
Electromyostimulation (EMS) of Astronauts in Spaceflight (Easymotion-2)
This is a prospective spaceflight study involving an investigational non-risk device called the EasyMotionSkin for whole body electric muscle (myo) stimulation (WB-EMS) onboard the International Space Station (ISS).
- Conditions
- Muscle Atrophy, Myotonia, Stiffness; Spine, Exercise Overtraining
- Trial name
- Easymotion-2 (NCT06492057)
- Testing
- Electromyostimulation (EMS), Myoton, Electromyography (EMG)
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Brain Involvement in Dystrophinopathies Part 2
The objective of this study is to understand the relationship between DMD and BMD brain comorbidities, and the location of the gene mutation which causes the disease.
- Trial name
- NCT04668716
- Where
- 7 sites in Denmark, France and 4 more
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
ALS (Amyotrophic Lateral Sclerosis), Postpoliomyelitis Syndrome
Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis
Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS.
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), Postpoliomyelitis Syndrome, Spinal Muscular Atrophy
- Trial name
- MotorMarker (NCT05663008)
- Testing
- 128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)
- Where
- Ireland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Aging, Sarcopenia
Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults
During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age.
- Conditions
- Aging, Sarcopenia, Sarcopenia in Elderly
- Trial name
- NCT06689618
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Osteoporosis, Sarcopenia
Osteoporosis and Sarcopenia Prevention in Middle-Aged Population
This initiative is designed to yield substantial and multi-level benefits for the Hong Kong community by pioneering a transformative model of preventive healthcare.
- Trial name
- FORTIFY (NCT07611097)
- Testing
- Intervention Group, Control Group
- Where
- Hong Kong
- Volunteers
- 8,336 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Muscle Disuse Atrophy
Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?
Ageing is associated with a gradual decline in muscle mass that is detrimental to both physical function and metabolic health, increasing the risk of morbidity and mortality.
- Trial name
- LEU-DIMA (NCT03762278)
- Testing
- Leucine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Atrophy, Disuse, Insulin Resistance
Bedrest, Feeding Pattern, and Insulin Sensitivity
In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.
- Trial name
- NCT02521025
- Testing
- Intermittent feeding pattern, Continuous feeding pattern
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Duchenne Dystrophy Muscular
Biomechanical and Morphological Changes in Dystrophic Muscle
The loss of ability to walk in many children with DMD (Duchenne muscular Dystrophy) is a pejorative event. Biomechanical and morphological unknowledge about the loss of the walk ability in children with DMD is an obstacle in…
- Trial name
- MARCHE-DMD (NCT02472990)
- Where
- 10 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Sarcopenia
Effect of Exercise and Protein Supplementation on Muscle Function in Patients With Hemodialysis
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis.
- Trial name
- NCT04927208
- Testing
- exercise and nutritional support
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Sarcopenia
Fish Protein Supplementation and Sarcopenia Outcomes in the Community
Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increase adverse outcomes including falls, functional decline, frailty and…
- Trial name
- SARCO_COMM (NCT05356559)
- Testing
- Intervention, Control
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Sarcopenia, Atrophy
Resistance Training in Elderly
In the present study the investigators aim to determine whether protein supplementation can augment the response to a 12 week resistance training program in healthy elderly men.
- Conditions
- Sarcopenia, Atrophy, Aging
- Trial name
- NCT00744094
- Testing
- protein drink, Resistance training
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia
Efficacy and Safety of Kefir Whey Postbiotics
Research staff conduct screening tests only on applicants who provide written consent and select research subjects who meet the selection criteria.
- Trial name
- NCT06230302
- Testing
- Whey postbiotics derived from kefir lactic acid bacteria
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Ageing
Study to Assess the Effect of Leucine Along With Resistance Exercise on Muscle Strength and Quality of Life in Elders
The purpose of this study is to determine whether a nutritional supplement with an amino acid called leucine along with resistance exercise are effective in the improvement of muscle strength and quality of life in elderly people.
- Trial name
- NCT00929929
- Testing
- L-leucine., Maltodextrin., Exercise program.
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Sarcopenia
Creatine Supplementation During GLP-1a Therapy
GLP-1 receptor agonists are effective for weight loss, but significant muscle mass is lost as a proportion of this weight loss. This study combines resistance-training and creatine supplementation to try to prevent this loss of…
- Trial name
- NCT07625202
- Testing
- Dietary supplementation during a 12 week resistance-training program (creatine)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan