Clinical trials: Musculoskeletal
Musculoskeletal Pain
Vitamin D to ENhance TraUma REcovery
The main objective of this study is to determine whether the administration of a single dose of Vitamin D in the Emergency Department following a motor vehicle collision can improve musculoskeletal pain severity as well as reduce…
- Trial name
- VENTURE (NCT05458024)
- Testing
- Vitamin D 2
- Where
- 4 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Musculoskeletal Pain, Pain, Chronic
NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly…
- Trial name
- NEPAL (NCT02488863)
- Testing
- MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires
- Where
- 4 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Florida
Nociceptive Pain, Musculoskeletal Pain
Clinical Trial of the invisaRED® IR REHAB Device When Used as an Adjunctive Therapy for Nociceptive Musculoskeletal Pain
This is a trial to measure the effectiveness and safety of the invisa-RED® IR REHAB device. The researchers will compare the muscle and joint pain relief of participants who are treated with the real machine, to those treated…
- Trial name
- NCT06393088
- Testing
- IR REHAB
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- IR Technology, LLC
Fibromyalgia, Myofascial Pain Syndromes
Repeat of: A Study to Evaluate Efficacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With Fibromyalgia
The present trial is designed to assess the safety and efficacy of TNX-102 SL 2.8 mg tablets, taken daily at bedtime after 12 weeks of treatment in patients with fibromyalgia.
- Conditions
- Fibromyalgia, Myofascial Pain Syndromes, Muscular Diseases, Nervous System Diseases
- Trial name
- RE-AFFIRM (NCT02829814)
- Testing
- TNX-102 SL Tablet, 2.8 mg
- Where
- 32 sites in United States
- Volunteers
- 51 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Postmenopausal Women With Osteoporosis
Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
The purpose of this study is to determine if treatment is effective in preventing fractures in women with postmenopausal osteoporosis.
- Trial name
- ARCH (NCT01631214)
- Testing
- Romosozumab, Alendronate
- Where
- 316 sites in United States, Argentina and 40 more
- Volunteers
- 4,093 people
- Sponsor
- Amgen
Fibromyalgia, Myofascial Pain Syndrome
Fibromyalgia Integrative Training for Adolescents With Juvenile Fibromyalgia
This study evaluated whether Fibromyalgia Integrative Training program for Teens (FIT Teens), a combined cognitive behavioral therapy and neuromuscular exercise training program is more effective in reducing disability in…
- Conditions
- Fibromyalgia, Myofascial Pain Syndrome, Muscular Diseases, Musculoskeletal Disease
- Trial name
- FIT Teens (NCT03268421)
- Testing
- Fibromyalgia Integrative Training for Teens, Cognitive Behavioral Therapy, Graded Aerobic Exercise
- Where
- 7 sites in United States, Canada
- Volunteers
- 389 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Fibromyalgia, Myofascial Pain Syndromes
A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgia
The use of low-dose CBP dosed nightly at bedtime for FM was supported by the results of Tonix' TNX-CY-F202 Phase 2b study (also referred to as the BESTFIT Study).
- Conditions
- Fibromyalgia, Myofascial Pain Syndromes, Muscular Diseases, Musculoskeletal Diseases
- Trial name
- AFFIRM (NCT02436096)
- Testing
- TNX-102 SL Tablet, 2.8mg
- Where
- 35 sites in United States
- Volunteers
- 519 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Musculoskeletal Pain, Chronic Shoulder Pain
Digital Versus Conventional Physical Therapy for Chronic Shoulder Tendinopathy
This is a single-center, prospective, randomised, controlled study, with two parallel groups, designed to assess the clinical impact of a digital exercise program against conventional rehabilitation for shoulder tendonitis.
- Conditions
- Musculoskeletal Pain, Chronic Shoulder Pain, Shoulder Tendinopathy
- Trial name
- NCT04636528
- Testing
- Digital rehabilitation, Conventional rehabilitation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Sword Health, SA
Arthralgia, Breast Cancer
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment
This randomized phase III trial studies testosterone to see how well it works compared to placebo in treating postmenopausal patients with arthralgia (joint pain) caused by anastrozole or letrozole.
- Conditions
- Arthralgia, Breast Cancer, Hot Flashes, Musculoskeletal Complications
- Trial name
- NCT01573442
- Testing
- testosterone
- Where
- 529 sites in United States, Puerto Rico
- Volunteers
- 227 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Chronic Musculoskeletal Pain
Implementation of Nurse-guided Web-based Cognitive Behavioral Therapy for Pain Management
To see if nurse guided web based cognitive behavioral therapy (CBT) will show pain improvement in patients with all types of pain complaints.
- Trial name
- NCT03927846
- Testing
- Nurse-guided Web-based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Musculoskeletal Pain
Optimizing Psychotherapy for Older Veterans With Chronic Pain
This study is being performed to compare the effects of two alternate types of psychotherapy, Cognitive Behavior Therapy (CBT) and Emotional Awareness and Expression Therapy (EAET), for chronic musculoskeletal pain in older…
- Trial name
- OPOVCP (NCT03918642)
- Testing
- Emotional Awareness and Expression Therapy, Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- VA Office of Research and Development
Musculoskeletal Injury Trauma
An Integrated-Delivery-of-Care Approach to Improve Patient Outcomes, Safety, Well-Being After Orthopaedic Trauma
Orthopedic trauma is an unforeseen life-changing event. Nearly 2.8 million Americans sustain traumatic orthopedic injuries such as major fractures or amputation each year.
- Trial name
- NCT02591472
- Testing
- Integrated care (ICare), Usual Care (UsCare), Patient-Reported Outcomes Measurement Information System
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Florida
Surgical Wound, Revision Total Knee Arthroplasty
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
This study evaluates surgical site complications in subjects undergoing revision of a total knee arthroplasty when closed incision negative pressure therapy is used to manage the closed incision, as compared to a standard of care…
- Conditions
- Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease
- Trial name
- PROMISES (NCT03274466)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
- Where
- 17 sites in United States
- Volunteers
- 294 people
- Sponsor
- KCI USA, Inc
Surgical Wound, Bilateral Total Knee Arthroplasty
Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA
This study will compare the effects of closed incision negative pressure dressing vs. standard of care silver dressing on lower limb swelling after bilateral primary total knee arthroplasty.
- Conditions
- Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases
- Trial name
- ENABLE (NCT04712019)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Solventum US LLC
Neck Pain, Chronic Pain
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
Given the modest effectiveness of current treatments and the burden chronic neck pain places on Veterans, the investigators' research proposal is significant in several regards.
- Conditions
- Neck Pain, Chronic Pain, Pain, Arthritis
- Trial name
- TOMCATT (NCT03100539)
- Testing
- Therapist treated massage, Care ally assisted massage
- Where
- United States
- Volunteers
- 395 people
- Sponsor
- VA Office of Research and Development
Orthopedic Disorder
Wearable Technology to Reduce Risk of DVT and Increase Patient Compliance
The primary purpose of this study is to conduct a multi-site clinical trial of the Recovery Force Movement and Compressions (RF MAC) System.
- Trial name
- SBIR2 (NCT04995601)
- Testing
- RF Health MAC
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Recovery Force LLC
Postmenopausal Osteoporosis
Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis
The purpose of this study is to determine if treatment with romosozumab is effective in preventing fractures in women with postmenopausal osteoporosis
- Trial name
- FRAME (NCT01575834)
- Testing
- Romosozumab, Denosumab
- Where
- 218 sites in United States, Argentina and 22 more
- Volunteers
- 7,180 people
- Sponsor
- Amgen
Duchenne Muscular Dystrophy
Phase 3 Trial of Pamrevlumab or Placebo in Combination With Systemic Corticosteroids in Participants With Ambulatory DMD
To evaluate the efficacy and safety of pamrevlumab versus placebo in combination with systemic corticosteroids administered every 2 weeks in ambulatory participants with Duchenne muscular dystrophy (DMD) (age 6 to <12 years).
- Trial name
- LELANTOS-2 (NCT04632940)
- Testing
- Pamrevlumab, Corticosteroids
- Where
- 52 sites in United States, Australia and 9 more
- Volunteers
- 73 people
- Sponsor
- Kyntra Bio
PTSD, Chronic Musculoskeletal Pain
Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)
This project is responsive to Rehabilitation Research and Development's (RR\&D) current special areas of interest for non-pharmacological activity-based interventions for chronic pain impacting pain reduction, function and…
- Trial name
- MR (NCT03593772)
- Testing
- Mission Reconnect
- Where
- 3 sites in United States
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD)
Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical…
- Conditions
- Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
- Trial name
- EXCPPTSD (NCT03283163)
- Testing
- Exercise Testing and Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development