Clinical trials: Musculoskeletal Cancers
Psoriatic Arthritis
A Study on Assessment of STELARA and Tumor Necrosis Factor Alpha Inhibitor Therapies in Participants With Psoriatic Arthritis
The purpose of this study is to evaluate treatment retention in psoriatic arthritis participants with STELARA or tumor necrosis factor alpha inhibitor (TNFi) therapies in relation to effectiveness, safety, benefit/risk and to…
- Trial name
- PsaBio (NCT02627768)
- Testing
- No Intervention
- Where
- 66 sites in Belgium, France and 5 more
- Volunteers
- 991 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Apical Periodontitis, Apical Granuloma
Factors Affecting the Endodontic Treatment Outcome
The aim of this prospective cohort observational study is: (i) to assess the endodontic treatment outcome in a private specialist endodontic office in Slovenia; (ii) to estimate the effect of various pre-, intra- and…
- Conditions
- Apical Periodontitis, Apical Granuloma, Apical Cyst
- Trial name
- NCT05221450
- Testing
- primary endodontic treatment
- Where
- Slovenia
- Volunteers
- 700 people
- Sponsor
- Odontos, Specialisticna Zobna Ambulanta, d.o.o.
Fibrodysplasia Ossificans Progressiva (FOP)
The Fibrodysplasia Ossificans Progressiva (FOP) Registry
The Fibrodysplasia Ossificans Progressiva (FOP) Registry is a global, non-interventional, voluntary database that captures demographic and disease data directly from FOP patients and their caregivers via a secure, web-based…
- Trial name
- NCT02745158
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- The International FOP Association
Breast Cancer, Osteoporosis
An Open Label Non-Interventional Evaluation of the Effect of Adjuvant Hormonal Treatment of Postmenopausal Women Wih Early Breast Cancer With Aromatase Inhibitors on Bone Mineral Density and Bone Fracture Rate in Daily Practice
The aim of this study is to determine the effect of aromatase inhibitors therapy on bone mineral density and compare it to the effects of tamoxifen and no hormonal therapy.
- Trial name
- NCT00767585
- Where
- Slovenia
- Volunteers
- 560 people
- Sponsor
- AstraZeneca
Breast Cancer, Mastectomy; Lymphedema
Myofascial Massage for Pain and Immobility Following Breast Cancer Surgery
About 25-50% of women who undergo breast cancer surgery develop persistent chest wall pain and shoulder mobility limitations following surgery.
- Conditions
- Breast Cancer, Mastectomy; Lymphedema, Pain, Shoulder, Mobility Limitation
- Trial name
- NCT04233385
- Testing
- Myofascial Massage, Light Touch
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- MetroHealth Medical Center
Acromegaly Due to Pituitary Adenoma, Cushing's Disease
PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours
The goal of this clinical trial is to evaluate whether a higher dose of radiotherapy can lead to better outcomes for participants with functioning pituitary tumours.
- Conditions
- Acromegaly Due to Pituitary Adenoma, Cushing's Disease, Pituitary Adenoma
- Trial name
- PRESTO (NCT07813351)
- Testing
- Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT)
- Volunteers
- 82 people
- Sponsor
- University College, London
Dupuytren's Disease
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions.
- Trial name
- Micronerves (NCT06142929)
- Testing
- Microfasciectomy
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovarian, Melanoma
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.
The present clinical trial is a dose comparison of a multi-component active immunotherapy designed to stimulate an immune reaction to specific tumor associated antigens which are highly expressed on a large number of solid…
- Conditions
- Ovarian, Melanoma, Renal, Prostate
- Trial name
- NCT00423254
- Testing
- PSMA/PRAME
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mannkind Corporation
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Rheumatoid Arthritis
SWITCH Clinical Trial for Patients With Rheumatoid Arthritis Who Have Failed an Initial TNF-blocking Drug.
The principal aim of this study is to fill a clear knowledge gap and provide guidance for rheumatologists and reassurance to the patient group on a management challenge faced daily in rheumatology practice.
- Trial name
- SWITCH (NCT01295151)
- Testing
- Etanercept, Abatacept, Rituximab
- Where
- United Kingdom
- Volunteers
- 122 people
- Sponsor
- Julia Brown
Dupuytren Contracture
Is wGRS Associated With DD Recurrence?
Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence.
- Trial name
- NCT02983162
- Where
- Netherlands
- Volunteers
- 427 people
- Sponsor
- University Medical Center Groningen
Arthralgia, Pain
Role of Biomarkers in Muscle Pain and Joint Pain in Patients With Solid Tumors Receiving Paclitaxel
RATIONALE: Learning about pain in patients with cancer receiving paclitaxel may help plan treatment and may help patients live more comfortably.
- Conditions
- Arthralgia, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT01096407
- Testing
- laboratory biomarker analysis, questionnaire administration, assessment of therapy complications
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Arthritis, Rheumatoid, Arthritis, Psoriatic
Characterization of Immunogenicity of TNF Inhibitors in Arthritis Patients With Poorer Treatment Response.
The aim of the study is to explore whether the influence of gender, tobacco smoking and obesity on treatment response in tumor necrosis factor inhibitors (TNFIs) can be explained by high degree of inflammation, human leucocyte…
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondylitis, Ankylosing
- Trial name
- NCT04731831
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aalborg University Hospital
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome
The hypothesis is that a subset of patients with chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME), including also patients with no clinical response after B-cell depletion therapy using the anti-CD20 antibody…
- Trial name
- NCT01730495
- Testing
- Etanercept
- Where
- Norway
- Volunteers
- 4 people
- Sponsor
- Haukeland University Hospital
Basal Cell Nevus Syndrome
Study of BMS-833923 in Two Specific Patients With Basal Cell Nevus Syndrome
This is an extension study of Protocol CA194002 to allow 2 specific participants with basal cell nevus syndrome in the CA194002 study at Princess Margaret Cancer Centre who are still benefitting from the study drug BMS-833923 to…
- Trial name
- NCT02100371
- Testing
- BMS-833923
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Spinal Tumor, Bone Tumor
Chemical Shift Encoding-based Water-fat Magnetic Resonance Imaging in Spinal Tumors
Fat composition of the spinal tumors is positively correlated with classification and differential diagnosis of benign and malignant tumors.
- Trial name
- NCT05631002
- Testing
- Chemical shift encoding-based water-fat MRI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Rheumatoid Arthritis
Efficacy and Safety of Olokizumab With Rheumatoid Arthritis With Previously Failed to Anti-tumor Necrosis Factor (Anti-TNF) Therapy
The primary objective of this study is to evaluate the efficacy and safety of CDP6038 administered subcutaneous (sc) at various doses compared to placebo.
- Trial name
- NCT01463059
- Testing
- Olokizumab 60 mg, Olokizumab 120 mg, Olokizumab 240 mg
- Where
- 39 sites in Japan, South Korea and 1 more
- Volunteers
- 119 people
- Sponsor
- UCB Japan Co. Ltd.
Insulin Resistance, Postoperative Complication
Evaluation of Preoperative Oral Rehydration Solution in Colectomy
Elective colectomy procedures typically require bowel preparation starting 2 days prior to the surgery. Osmotic laxatives such as Colyte® are administered 2 days prior, and Nothing by mouth (NPO) is required 1 day prior to ensure…
- Trial name
- NCT02062788
- Testing
- Oral rehydration solution
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Vitamin D3 for Aromatase Inhibitor Induced Arthralgias
The primary purpose is to determine if high dose vitamin D3 reduces the incidence of musculoskeletal symptoms associated with the aromatase inhibitor letrozole in women with early stage breast cancer and low serum vitamin D…
- Trial name
- VITAL (NCT00867217)
- Testing
- High Dose Vitamin D, Standard Dose Vitamin D3, Letrozole 2.5mg
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Qamar Khan
Bone Tumors
Vascular CT Assessment of Structural Autograft and Allograft Healing
The purpose of this study is to determine the ability of a cone beam CT to measure bone healing.
- Trial name
- NCT00594776
- Testing
- Cone Beam CT Scan
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Rochester
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