Clinical trials: Musculoskeletal Complication
Lumbar Disc Herniation, Pain, Postoperative
mTLIP vs. ITP Blocks in Lumbar Disc Surgery
to compare ultrasonography (USG)-guided intertransverse process block and modified thoracolumbar interfascial plan (mTLIP) block in the treatment of postoperative pain in patients undergoing lumbar disc herniation surgery under…
- Conditions
- Lumbar Disc Herniation, Pain, Postoperative, Regional Aneshesia
- Trial name
- NCT06391541
- Testing
- modified thoracolumbar interfacial plan block (mTLIP), Intertransverse process block (ITP)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Diabetic Foot, Hammer Toe
Treatment of Impending Ulcers Associated With Hammer, Mallet and Claw Toe Deformities in the Diabetic Patient Setting
Patients with diabetes, hammer, mallet and claw toes and impending ulcers associated with hammer mallet and claw toes will be randomized to tenotomy (cutting) of flexor tendons to the afflicted toes, done by needle and standard…
- Conditions
- Diabetic Foot, Hammer Toe, Mallet Toe, Claw Toe
- Trial name
- TODDIII (NCT04154046)
- Testing
- Tenotomy(cutting) of flexor tendons is performed with needle
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Steno Diabetes Center Copenhagen
Urolithiasis, Renal Colic
Metabolic Workup in Patients Suffering From Kidney Stone Disease and Osteopenia
Patients suffering from acute renal colic are evaluated by non contrast computerized tomography with excellent identification rates of urinary stones.
- Conditions
- Urolithiasis, Renal Colic, Osteopenia
- Trial name
- NCT04080973
- Testing
- CT scan, 24 hour urine collection
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Ziv Hospital
Lumbar Disc Herniation
Plane Block vs Intravenous Patient Controlled Analgesia
Acute postoperative pain begins with surgical trauma and decreases with tissue healing. Untreatable postoperative pain is one of the most important problems due to the increase in respiratory, cardiac and thromboembolic…
- Trial name
- NCT04457986
- Testing
- Erector spina plane block (ESP), Modified thoracolumbar interfacial plane block (MTI), Intravenous patient controlled analgesia (IV-PCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Diskapi Teaching and Research Hospital
Surgery, Knee Osteoarthritis
Bypass PACU in Knee and Hip Arthroplasty
A Quality Study in the use of Post-Anaesthesia Care Unit(PACU) in Hip and Knee Arthroplasty, and the ability to bypass this unit.
- Conditions
- Surgery, Knee Osteoarthritis, Postoperative Complications, Hip Osteoarthritis
- Trial name
- NCT03984942
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Niklas Ingemann Nielsen
Pain, Postoperative, Osteoarthritis
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
- Trial name
- NCT00270322
- Testing
- Marcaine 0.166% + Fentanyl 3.33 mcg/ml, Morphine sulphate
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Postoperative Pain
Comparison of the Efficacy of PENG Block in Combination With LFCN Block and Wound Infiltration
The ultrasound-guided approach for the blockade of articular branches of femoral and obturator nerves, pericapsular nerve group (PENG) block, is an effective method for postoperative analgesia in hip surgeries.
- Trial name
- NCT04681222
- Testing
- LFCN, Wound infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Derince Training and Research Hospital
Pain, Osteoarthritis, Hip
Modulation of the Surgical Inflammatory Response by Etoricoxib
The purpose of this study is to test the hypothesis that orally administered etoricoxib (COX-2) modulates prostaglandin and cytokine synthesis in the central nervous system (CNS) and in the periphery in surgical patients and thus…
- Conditions
- Pain, Osteoarthritis, Hip, Postoperative Pain
- Trial name
- NCT00746720
- Testing
- Etoricoxib 60 mg
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Osteoporosis, Chronic Kidney Disease Mineral and Bone Disorder
Osteoporosis & Renal Disease: Research in Primary Health Care Services
Osteoporosis, a silent and multifactorial systemic skeletal disorder, severely compromises bone strength and significantly increases the risk of fragility fractures.
- Trial name
- NCT07848490
- Testing
- Fracture risk assessment tool (FRAX), Dual-Energy X-ray Absorptiometry (DXA)
- Where
- Portugal
- Volunteers
- 622 people
- Sponsor
- Universidade do Porto
Edentulous Alveolar Ridge in Mandible
SFI Bars and Milled Bars Supporting Mandibular Overdentures. Three-year Randomized Clinical Trial
The aim of this study will be to evaluate the marginal bone loss and prosthetic complications of stress-free implant (SFI) and milled bars used to assist mandibular 4-implant overdentures after 3 years
- Trial name
- NCT06620497
- Testing
- stress free implant bar, milled bar
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Fayoum University
Knee Osteoarthritis, Bone; Deformity, Congenital
COREV 2.0 PMCF-Study on Manual and Navigated Revision Knee Patients
The Columbus® Revision endoprosthetic system is bearing the CE-mark. This means that within the scope of this observational study the patient will not be subjected to any additional stressful, study-related medical examinations…
- Conditions
- Knee Osteoarthritis, Bone; Deformity, Congenital, Prosthesis Failure, Prosthesis-Related Infections
- Trial name
- COREV (NCT05113303)
- Testing
- Navigated Revision Total Knee Arthroplasty, Manual Revision Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Intra-Abdominal Hypertension, Postoperative Complications
The Impact of Intra-Abdominal Pressure on Mortality and Morbidity in Patients Undergoing Open-Heart Surgery
This prospective observational study evaluated whether increased intra-abdominal pressure, meaning increased pressure inside the abdomen, is associated with postoperative complications and mortality in adults undergoing elective…
- Trial name
- NCT07752082
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Alveolar Bone Resorption, Alveolar Ridge Trauma
Vertical Ridge Augmentation Strategies
Guided Bone Regeneration (GBR) is an invaluable and beneficial surgical technique adopted when there is the need to augment an alveolar atrophy.
- Conditions
- Alveolar Bone Resorption, Alveolar Ridge Trauma, Alveolar Bone Loss, Complication of Surgical Procedure
- Trial name
- VARGAS (NCT06242782)
- Testing
- VRA + d-PTFE membrane, VRA + e-PTFE membrane, VRA + customised Ti-mesh
- Volunteers
- 148 people
- Sponsor
- University College, London
Osteoarthritis, Hip, Hip Osteoarthritis
Clinical and Functional Outcome of the MobileLink Acetabular Cup System in the Short-, Mid-, and Longterm Follow-up
The implantation of artificial hip joints is one of the most frequently performed surgeries. Normally, patients are very satisfied with the results. The MobileLink hip prosthesis system is a CE marked medical device.
- Conditions
- Osteoarthritis, Hip, Hip Osteoarthritis, Prosthesis Survival, Prosthesis Failure
- Trial name
- NCT04688593
- Testing
- MobileLink
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 520 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Head and Neck Cancer, Pain, Musculoskeletal
Continous Popliteal Block for Microvascular Free Flap Reconstruction in Ear, Nose and Throat Surgery
The aim of the study is to assess the effects of a continuous popliteal block on postoperative pain and recovery after major ear, nose and throat surgery with microvascular free flap reconstruction using a fibula graft.
- Trial name
- NCT03607227
- Testing
- Levobupivacaine, Saline Solution
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Skane
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors
This longitudinal observational study examines how social health, including social support, social roles, loneliness, social anxiety, and social network characteristics, relates to physical activity, sedentary time, and quality…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT07259304
- Testing
- Medical Device Usage and Evaluation, Quality-of-Life Assessment, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 173 people
- Sponsor
- University of Southern California
Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Hypophosphatemia, X-linked Hypophosphatemia
FGF23 and Angiotensin-(1-7) in Hypophosphatemia (GAP)
Hereditary hypophosphatemia encompasses rare genetic conditions characterized by renal phosphate wasting. Increased circulating levels of fibroblast growth factor 23 (FGF23), a key regulator of phosphorus metabolism, are critical…
- Conditions
- Hypophosphatemia, X-linked Hypophosphatemia, Renin-angiotensin System, Left Ventricular Hypertrophy
- Trial name
- GAP (NCT03489993)
- Testing
- Ang II and Ang-(1-7), FGF23 and klotho
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences
Cervical Spondylosis
Evaluation on Efficacy of Total Artificial Disc Replacement (TDR) of Cervical Spondylosis
To evaluate the efficacy of 3 different types of cervical disc prosthesis (Prodisc-C, Mobi-C and Prestige-LP) in the treatment of cervical spondylosis.
- Trial name
- NCT03364816
- Testing
- TDR
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Neuromuscular Disease, Malignant Hyperthermia
The Prevalence of RYR1-related Disease
The skeletal muscle ryanodine receptor (RYR1) gene encodes an important calcium channel in skeletal muscle, with an important role in muscle contraction. Mutations (i.e.
- Conditions
- Neuromuscular Disease, Malignant Hyperthermia, Congenital Myopathy, Multiminicore Disease
- Trial name
- NCT06791369
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- King's College London
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