Clinical trials: Musculoskeletal Complication
Turner Syndrome, Idiopathic Short Stature
Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature
Growth hormone treatment improves body fat distribution but also causes insulin resistance. Scientists have recently linked insulin resistance with special stores of fat in the muscles, which can be measured by magnetic resonance…
- Trial name
- NCT00121875
- Testing
- somatropin (rDNA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Osteoporosis
Guangzhou Nutrition and Health Study (GNHS)
Purpose: The Guangzhou Nutrition and Health Study (GNHS) project aims to assess the determinants of metabolic disease in nutritional aspects, as well as other environmental and genetic factors, and explore possible mechanisms…
- Conditions
- Cardiovascular Diseases, Osteoporosis, Diabetes Mellitus, Type 2, Metabolic Syndrome
- Trial name
- GNHS (NCT03179657)
- Volunteers
- 5,118 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Arthroplasty Complications, Pain, Joint
Efficacy of iPACK After Unilateral TKA
Total knee arthroplasty (TKA) is a common orthopedic procedure associated with severe postoperative pain which may limit patient rehabilitation and hospital discharge.
- Conditions
- Arthroplasty Complications, Pain, Joint, Arthritis Knee, Regional Anesthesia Morbidity
- Trial name
- NCT04565093
- Testing
- iPACK, Periarticular local infiltration analgesia (LIA)
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Khalid University Hospital
Pectus Carinatum, Quality of Life
Health-related Quality of Life in Patients Undergoing Surgery for Pectus Carinatum
The purpose of the study is to assess changes in health-related quality of life in patients undergoing surgical correction of pectus carinatum.
- Conditions
- Pectus Carinatum, Quality of Life, Pain, Postoperative, Somatosensory Disorders
- Trial name
- HRQoL (NCT01692392)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Peri-Implantitis, Implant Complication
"Surgical Vs. Non-surgical Peri-implant Therapy"
The aim of this randomized clinical trial is to evaluate the effectiveness, in terms of clinical and radiographic changes, of non-surgical peri-implant therapy (mechanical/chemical) versus regenerative surgical therapy (xenograft…
- Conditions
- Peri-Implantitis, Implant Complication, Bone Loss
- Trial name
- NCT05168891
- Testing
- Surgical therapy, Non-surgical therapy of peri-implantitis
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Arthropathy, Neurogenic, Diabetes Complications
Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy
The study is designed to investigate biomarkers related to bone turnover in diabetics with charcot foot. This is done by measuring local blood samples in the feet, and systemically in a vene and an artery.
- Conditions
- Arthropathy, Neurogenic, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT02386579
- Testing
- Blood sample measurements
- Volunteers
- 5 people
- Sponsor
- Bispebjerg Hospital
Diabetic Angiopathies, Bone Diseases, Metabolic
Microcirculation and Bone Metabolism in Patients With Type 2 Diabetes Mellitus and Charcot Foot - A Pilot Study
This study is part of a research project for a University MD Program. This is an observational study aimed at comparing the differences in bone metabolism and microcirculation in patients with type 2 diabetes mellitus (with and…
- Trial name
- NCT02435329
- Testing
- Baseline comparison of microcirculation and bone metabolism
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tameside General Hospital
Postoperative Pain, Myalgia
Effects of Preemptive Paracetamol and Ibuprofen on Headache and Myalgia in Patients After Electroconvulsive Therapy
The primary aim this prospective, randomized, double-blind, placebo-controlled clinical trial is to compare the analgesic effects of preemptive intravenous paracetamol and ibuprofen on headache and myalgia, and secondary aim is…
- Conditions
- Postoperative Pain, Myalgia, Headache
- Trial name
- ECT (NCT03783312)
- Testing
- paracetamol, ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Inonu University
Diabetic Foot Ulcer, Coronary Artery Disease
Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT)
This pilot study wants to determine to which extent SPCCT allows obtaining images with improved quality and diagnostic confidence when compared to standard Dual Energy CT (DECT), both with and without contrast agent injection.
- Conditions
- Diabetic Foot Ulcer, Coronary Artery Disease, Parenchymatous; Pneumonia, Kidney Stone
- Trial name
- SPEQUA (NCT04328181)
- Testing
- Spectral Photon Counting Computed Tomography (SPCCT), DECT (Dual Energy CT)
- Where
- France
- Volunteers
- 339 people
- Sponsor
- Hospices Civils de Lyon
Pelvic Floor Muscle Electrophysiologic Therapy, Fast-Track Surgery
Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery
This study is to evaluate the effect of pelvic floor muscle electrophysiologic therapy on enhanced recovery after gynecologic surgery,to solve muscle soreness and retention of urine after laparoscopy, and endometrial repair after…
- Trial name
- NCT03524807
- Testing
- Electrophysiologic therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Renal Osteodystrophy
Cholecalciferol Versus Doxercalciferol in the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease
The majority of patients with moderate to severe chronic kidney disease (CKD) (stages 3 and 4) develop secondary hyperparathyroidism (2°HPT), but the optimal therapy to control hyperparathyroidism in this group is unknown.
- Trial name
- NCT00285467
- Testing
- doxercalciferol, Cholecalciferol
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Indiana University
Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation
NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients
Patients requiring prolonged time on the ventilator are susceptible to a wide range of clinical complications and excess mortality. It is therefore imperative for them to wean at the earliest possible time.
- Conditions
- Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation, Muscle Weakness
- Trial name
- NCT03453944
- Testing
- VentFree prototype (VF03-K) active stimulation
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Nijmegen
Total Knee Replacement, Total Knee Arthroplasty
Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System
The purpose of this study is to determine if electrical stimulation (small levels of electricity) can safely and effectively reduce pain following total knee replacement (or total knee arthroplasty (TKA)).
- Conditions
- Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain
- Trial name
- NCT02468934
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- SPR Therapeutics, Inc.
Shoulder Joint Disease, Complications; Arthroplasty
Tranexamic Acid in Reverse Total Shoulder Arthroplasty
To the Investigators' knowledge, TXA has not been studied in the setting of reverse total shoulder arthroplasty. We propose a double-blinded, randomized, controlled trial comparing perioperative administration of TXA to placebo…
- Conditions
- Shoulder Joint Disease, Complications; Arthroplasty, Intraoperative Complications, Blood Loss, Surgical
- Trial name
- TXA (NCT02043132)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Corewell Health East
Type 2 Diabetes Mellitus
Effects of Physical Exercise on Blood Glucose and Pain From the Musculoskeletal System in Patients With Type 2 Diabetes
The aim of this study is to investigate the effects og physical exercise on bloodglucose and pain from the musculoskeletal system in patients with type 2 diabetes.
- Trial name
- NCT02366416
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Nordsjaellands Hospital
Diabetic Foot
Less Infections for the Diabetic Foot
This is a randomized, unblinded, single-centre study. After eventual surgical debridement (not amputation), patients will be randomized to receive 1 of 2 targeted antibiotic regimens, in the ratio 1:1.
- Trial name
- NCT03615807
- Testing
- Surgical debridement (if needed), Microbiological sampling, Revascularisation (if needed).
- Where
- Switzerland
- Volunteers
- 182 people
- Sponsor
- University Hospital, Geneva
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome
- Trial name
- NCT01601171
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Dentofacial Deformities, Analgesia
Effects of Local Ketamine in Orthognathic Procedures
Orthognathic surgery is performed to correct congenital, developmental, or trauma-related skeletal deformities of the maxilla and mandible.
- Conditions
- Dentofacial Deformities, Analgesia, Vomiting, Postoperative, Nausea, Postoperative
- Trial name
- NCT07066306
- Testing
- Ketamine, Articaine Hydrochloride + Epinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Musculoskeletal Complication
Virtual Physical Therapy Support for Runners
This study will compare standard of care of home exercise for running rehabilitation to the combined treatment of home exercise with an individually provided four-session virtual physical therapy support program intervention on…
- Trial name
- NCT05994833
- Testing
- VPT
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Florida
Osteoarthritis, Knee
Robotic-assisted (MAKO) Versus Manual Total Knee Arthroplasty for Knee Osteoarthritis
Background: Total knee arthroplasty is a golden standard procedure for end-stage knee osteoarthritis. However, up to 20% of the patients are not satisfied with the outcome.
- Trial name
- NCT07201207
- Testing
- Robotic-assisted total knee arthroplasty, Manual total knee arthroplasty
- Volunteers
- 170 people
- Sponsor
- Satakunta Central Hospital
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