Clinical trials: Musculoskeletal Function
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Osteoarthritis, Knee
Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty
Introduction: The current evidence on the efficacy of Antibiotic Loaded Bone Cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient.
- Trial name
- ALBA (NCT04135170)
- Testing
- ALBC vs plain bone cement
- Where
- Norway
- Volunteers
- 9,172 people, healthy volunteers welcome
- Sponsor
- The Norwegian Arthroplasty Register
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
MItochondrial Myopathies, Mitochondrial Disease
Validation of Nanosensor Oxygen Measurement
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM).
- Trial name
- NCT06819683
- Testing
- Nanosensor
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Sarcopenia, Osteopenia
Nutrient Support to Body Composition and Healthy Ageing
The focus is healthy ageing, i.e. delaying the deterioration in health status in older adults. Loss of lean tissue (skeletal muscle) mass, a process termed sarcopenia, or bone tissue mass, a process called osteopenia, is a…
- Trial name
- BCHA (NCT02529124)
- Testing
- CONTROL, PROTEIN, PHYSICAL ACTIVITY
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Phil Jakeman
Ankle Arthroplasty, Prosthesis User
3D X-ray Motion Analysis of Ankle-foot Motion After Total Ankle Arthroplasty
Patients who have had a total ankle joint replacement surgery typically have limited movement in their ankles possibly due to the fact that commonly used ankle joint prosthetic devices only allow limited axes of motion.
- Conditions
- Ankle Arthroplasty, Prosthesis User, Joint Disease
- Trial name
- NCT03575975
- Testing
- Total Ankle Replacement Prosthesis
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Pomegranate (P. Granatum) Peel Compress
The Effect of Pomegranate (Punica Granatum L.) Peel Compress Application on Pain and Physical Function Status
Osteoarthritis is the most common type of arthritis among rheumatologic diseases. Complementary therapies are one of the effective methods for pain control. This study was planned as a randomized controlled experimental study.
- Trial name
- Pomegranate (NCT06034106)
- Testing
- Pomegranate (Punica granatum) peel compress, Hot compress
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Fibromyalgia, Respiratory Alkalosis and Metabolic Acidosis
Evaluation of Respiratory Function in Fibromyalgia
This study will evaluate respiratory function in people with fibromyalgia and whether or not breathing patterns in this patient group can be explained by stress, emotional or biomechanical variables.
- Conditions
- Fibromyalgia, Respiratory Alkalosis and Metabolic Acidosis, Chronic Hyperventilation
- Trial name
- NCT04098731
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Rotator Cuff Tear Arthropathy
the Effect of Core Stability on Hand Functions
Determining the factors affecting hand function after upper limb injuries is very important for maintaining independence in daily living activities.
- Trial name
- NCT06105398
- Testing
- clinical evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Gülçe İrem Yalçınkaya
Pelvic Girdle Pain, Diastasis Recti and Weakness of the Linea Alba
The Association Between Pelvic Floor Muscle Function, Diastasis Recti and Postpartum Pelvic Girdle Pain - a Matched Case Control Study.
Background: Pregnancy-related pelvic girdle pain (PGP) can appear during pregnancy, directly after labour or can be delayed to 3 weeks postpartum.
- Conditions
- Pelvic Girdle Pain, Diastasis Recti and Weakness of the Linea Alba, Pelvic Floor Disorders
- Trial name
- NCT04757077
- Where
- Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Żelazna Medical Centre, LLC
Shoulder Pain, Diaphragm Issues
Functional Movement Analysis (FMS) of Diaphragmatic Breathing-Immediate Effect on Shoulder Mobility
The diaphragm is defined as a thin, smooth muscle that separates the thoracic and abdominal cavities. The shoulder and diaphragm muscle have a clear relationship through innervation and myofascial tissue connection.
- Trial name
- NCT05748522
- Testing
- Shoulder Mobility, Diaphragmatic Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Facioscapulohumeral Muscular Dystrophy
Quantitative Assessment of Orofacial Muscle Function in FSHD
The goal of this study is to validate a new method for the assessment of orofacial muscles in FSHD affected individuals
- Trial name
- NCT06425445
- Testing
- Orofacial function assessment tests
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Mons
Cryotherapy Effect
Behaviour After Exercise of Biological, Clinical and Metabolic Variables as From Different Temperatures and Times of Immersion Cold Water Application
Introduction: immersion cold water is a recuperative strategy commonly used, however, are not yet fully understood the real effects of this technique on specific conditions.
- Trial name
- NCT02497495
- Testing
- immersion cold water
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Paulista University
Mitochondrial Myopathies, Mitochondrial Diseases
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM).
- Trial name
- NCT04086329
- Testing
- Nanosensor
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Lumbar Spinal Stenosis
Sensory Integration Therapy Training in Patients With Lumbar Spinal Stenosis
Lumbar spinal stenosis is a common degenerative disease in the elderly. Patients are often accompanied by paresthesias and decreased musculoskeletal system functions, resulting in disability and increasing the burden of medical…
- Trial name
- NCT05425667
- Testing
- virtual reality walking training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Joint Instability
Knee Function in Patients With Two or More Episodes of Patella Dislocations
Patients aged 12 - 30 years, with recurrent patella dislocations, are consecutively included into a randomized prospective study. This study comparess the outcome of two forms of treatment for recurrent patella dislocation.
- Trial name
- MPFL (NCT02263807)
- Testing
- MPFL Group, Control
- Where
- 2 sites in Norway
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Asbjorn Aroen
Pes Planus, Flatfoot
Central Sensitization and Nociplastic Pain in Pes Planus
Background: Pes planus, commonly known as flatfoot, is a condition characterized by the collapse of the medial longitudinal arch of the foot.
- Conditions
- Pes Planus, Flatfoot, Central Sensitization, Nociplastic Pain
- Trial name
- NCT07125781
- Where
- Turkey (Türkiye)
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Bozok University
Osteoarthritis
Functional Exercise Response on osteoArthritis Relaxation Imaging
Osteoarthritis (OA) is the most prevalent cause of mobility impairment and disability in the elderly. Indications at early stages of OA include decreased organisation of the collagen matrix, loss of proteoglycans and increased…
- Trial name
- FERARI (NCT03657303)
- Testing
- Magnetic resonance imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Aging, Physical Fitness
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass.
- Trial name
- MOXI (NCT00462722)
- Testing
- Ibuprofen, musculoskeletal-loading exercise
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver