Clinical trials: Musculoskeletal Injury Trauma
Maxillofacial Injuries, Maxillofacial Trauma
Superficial Cervical Plexus Block for Orthognathic Surgery
US-guided superficial cervical plexus block (SCPB) may be used for several head and neck surgeries. Local anesthetic is injected under the sternocleidomastoid muscle for SCPB.
- Conditions
- Maxillofacial Injuries, Maxillofacial Trauma, Maxillofacial Abnormalities, Maxillofacial Dysostosis
- Trial name
- NCT04442009
- Testing
- Group SCPB
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Spinal Cord Injuries, Shoulder Impingement Syndrome
Freehand Ultrasound to Evaluate Scapular Kinematics in People With Paraplegia
Shoulder pain is very common in people with spinal cord injury (SCI). Persons with high-level paraplegia have higher chances to suffer shoulder pain and injury than those with lower-level paraplegia due to the shoulder muscle…
- Trial name
- FUS (NCT02357914)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Spinal Cord Injury, Amyotrophic Lateral Sclerosis
iBCI Optimization for Veterans With Paralysis
VA research has been advancing a high-performance brain-computer interface (BCI) to improve independence for Veterans and others living with tetraplegia or the inability to speak resulting from amyotrophic lateral sclerosis…
- Conditions
- Spinal Cord Injury, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome
- Trial name
- NCT05470478
- Testing
- Mobile neural decoding platform (mobile iBCI)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Lumbar Spinal Stenosis, Carpal Tunnel Syndrome (CTS)
124I-Evuzamitide PET/CT Imaging In Patients With Lumbar Spinal Stenosis and Carpal Tunnel Syndrome
This clinical trial will use the amyloid-binding radiotracer, 124I-evuzamitide, to potentially detect amyloid, in the heart and elsewhere, in patients who have a history of lumbar spinal stenosis and/or carpal tunnel syndrome.
- Conditions
- Lumbar Spinal Stenosis, Carpal Tunnel Syndrome (CTS), Cardiac Amyloidosis
- Trial name
- NCT06907849
- Testing
- 124I-evuzamitide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Anterior Cruciate Ligament Injury, Muscle Weakness
WEakness and Atrophy: isoKinetic With Surface Electromyography Assessment in ACL Surgery
An assessment of the effect of surgical anterior cruciate ligament (ACL) on thigh muscles is critical to the improvement of knee rehabilitation and preservation.
- Trial name
- WEAKNESS (NCT03200678)
- Testing
- isokinetic assessment
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Carpal Tunnel Syndrome, Trigger Finger
Tourniquet vs. No Tourniquet for Carpal Tunnel and Trigger Finger Release
Background: Trigger finger and carpal tunnel syndrome are two of the most common conditions treated by the hand surgeon. During these procedures, a tourniquet is often used to minimize bleeding and improve visualization of the…
- Trial name
- NCT04354415
- Testing
- Carpal tunnel or trigger finger release
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Anarthria, Dysarthria
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with…
- Conditions
- Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Speech-01 (NCT05724173)
- Testing
- BrainGate Neural Interface System
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Musculoskeletal Disorder, Mental Health Issue
An Integrated Approach to Health, Wellbeing, and Productivity at Work
The goal of the workplace intervention study 'An Integrated Approach to Health, Wellbeing, and Productivity at Work (ITASPA)' is to examine the effect of the Australian WorkHealth Improvement Network (WIN) program in a Danish…
- Conditions
- Musculoskeletal Disorder, Mental Health Issue, Work-related Illness, Safety Issues
- Trial name
- ITASPA (NCT05866978)
- Testing
- Integrated Approach to Health, Wellbeing, and Productivity at Work (ITASPA)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Trapeziometacarpal Arthrosis, Carpal Tunnel Syndrome
A Randomized Trial Measuring the Effect of Decision Aids on Patients' Satisfaction, Conflict of Decision-making and Clinical Outcome
The investigators plan a prospective randomized controlled study that compares the treatment decisions made by patients who receive decision aids, as compared to patients treated with usual care and the American Society for…
- Conditions
- Trapeziometacarpal Arthrosis, Carpal Tunnel Syndrome, Cubital Tunnel Syndrome, Distal Radius Fractures
- Trial name
- NCT01693094
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Massachusetts General Hospital
Muscle Spasticity
Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury
A drug called AV650 (tolperisone HCl) will be given to patients who have spasticity following a spinal cord injury. This study has three purposes: 1. To determine whether AV650 is safe for patients with spinal cord injury; 2.
- Trial name
- NCT00531466
- Testing
- tolperisone HCl (AV650)
- Where
- 10 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Avigen
Osteoporosis, Accidental Falls
The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.
A digital education for osteoporosis patients (DEOP) has been developed and tested on patients in Region Vastra Gotaland, Sweden.
- Conditions
- Osteoporosis, Accidental Falls, Fractures, Bone, Patient Reported Outcome Measures
- Trial name
- NCT06603545
- Testing
- Digital education for osteoporosis patients
- Volunteers
- 2,640 people
- Sponsor
- Sahlgrenska University Hospital
Vitamin D Deficiency, Polytrauma
Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients
Although vitamin D is known to play a major role in multiple organ functions in healthy adults, including bone homeostasis, its role in the unique population of orthopaedic polytrauma patients has not been well described.
- Conditions
- Vitamin D Deficiency, Polytrauma, Orthopedic Disorder
- Trial name
- NCT03066817
- Testing
- Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL], Propylene Glycol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York City Health and Hospitals Corporation
Musculoskeletal Pain
Vitamin D to ENhance TraUma REcovery
The main objective of this study is to determine whether the administration of a single dose of Vitamin D in the Emergency Department following a motor vehicle collision can improve musculoskeletal pain severity as well as reduce…
- Trial name
- VENTURE (NCT05458024)
- Testing
- Vitamin D 2
- Where
- 4 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild…
- Trial name
- GRIT (NCT04867317)
- Testing
- Somatropin
- Where
- 16 sites in United States
- Volunteers
- 172 people
- Sponsor
- VA Office of Research and Development
Degenerative Joint Disease, Osteoarthritis
Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery
This study is to determine the relevancy of clinical scales for outcome measures as compared to flexion angle and other gait measures.
- Conditions
- Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder
- Trial name
- TKR (NCT01379118)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Knee Osteoarthritis
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis.
- Trial name
- KNEE (NCT07833488)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Knee Osteoarthritis, Anterior Cruciate Ligament Injury
Protective Role of Muscle Function for Early Features of Knee Osteoarthritis After Anterior Cruciate Ligament Injury
In this longitudinal prospective cohort study including young people with anterior cruciate ligament reconstruction (ACLR), the aims are to 1) study the association between different measures of muscle function and early future…
- Conditions
- Knee Osteoarthritis, Anterior Cruciate Ligament Injury, Osteoarthritis, Knee, Muscle Weakness
- Trial name
- SHIELD (NCT03473873)
- Testing
- Measures of muscle function
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 106 people
- Sponsor
- Lund University
Osteoarthritis
Stromal Vascular Fraction (SVF) for Knee Post-Trauma Osteoarthritis (PTOA)
This is a prospective, non-randomized, interventional, dual site, before-after clinical trial to determine feasibility and safety of a single injection of autologous Adipose Derived (AD) Stromal Vascular Fraction (SVF) for the…
- Trial name
- SVF (NCT05515523)
- Testing
- Adipose Derived (AD) Stromal Vascular Fraction (SVF)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences