Clinical trials: Musculoskeletal Model
Musculoskeletal Pain
Multimodal Management of Neck and Back Pain in the Emergency Department (Multi-ED)
The purpose of this study is to assess the feasibility and acceptability of psychologically-informed physical therapy (PIPT) in the ED in a pilot study of ED patients with neck or back pain.
- Trial name
- NCT05221125
- Testing
- Psychologically-Informed Physical Therapy (PIPT)
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Duke University
IBD - Inflammatory Bowel Disease, RA - Rheumatoid Arthritis
A Pharmacokinetic-pharmacodynamic Modeling and Simulation Study of Subcutaneous Infliximab in Patients With Inflammatory Bowel Disease
A subcutaneous formulation of infliximab CT-P13 (Remsima, Celltrion) has been approved for clinical use in inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) after demonstration of pharmacokinetic (PK) non-inferiority…
- Trial name
- NCT07120152
- Testing
- Subcutaneous infliximab CT-P13 Remsima®SC
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Erwin Dreesen
Vasomotor Symptoms, Urinary Incontinence
Nurse-led Primary Healthcare Intervention Model in Women's Health Management in Hong Kong
The goal of this randomized clinical trial is to learn if a nurse-led primary healthcare intervention can help improve health management in women adults aged 45 to 64, and to develop an evidence-based primary healthcare model for…
- Conditions
- Vasomotor Symptoms, Urinary Incontinence, Anxiety, Depression - Major Depressive Disorder
- Trial name
- JCDATAZONEWH (NCT06628388)
- Testing
- Nurse-Led Risk-Based 5As Primary Healthcare Model, Minimal Intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,728 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Osteoarthritis, Knee
Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
The goal of this study is to validate the pharmacodynamic model for pain relief from oxytocin at a peripheral site by intravenous infusion targeted at different levels of the drug.
- Trial name
- NCT04435704
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Spinal Muscular Atrophy Type 3, Duchenne Muscular Dystrophy
Wearable Technology to Assess Gait Function in SMA and DMD
The purpose of this project is to devise instrumented insoles capable of accurately measuring gait at each footfall, over multiple hours in any environment.
- Trial name
- NCT04193085
- Testing
- Observational
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Columbia University
Bone Loss
A Prospective Study of Human Bone Adaptation Using a Novel in Vivo Loading Model
The purpose of this study is to understand how different types of mechanical forces can influence bone adaptation (and make bones stronger, potentially). Forces acting on bones cause mechanical strain.
- Trial name
- NCT04135196
- Testing
- voluntary forearm loading task
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Worcester Polytechnic Institute
Osteonecrosis
Molecular Genetic Study of Avascular Necrosis of the Femoral Head
Avascular necrosis of the femoral head (ANFH) is a debilitating disease that commonly leads to destruction of the hip joint in patients at middle age of life and often requires surgical intervention.
- Trial name
- NCT00260897
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Musculoskeletal Pain, Healthy
Multivariable Recovery After Exercise-induced Muscle Pain in the Forearm Muscles
This study investigates the evolution of sensory, motor and tissue variables following exercise-induced pain in wrist extensor muscles in healthy subjects.
- Conditions
- Musculoskeletal Pain, Healthy, Delayed Onset Muscle Soreness
- Trial name
- NCT04012203
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Musculoskeletal Pain
Study of Epicutaneously Applied Ketoprofen Transfersome® Gel With or Without Combination With Oral Celecoxib for the Treatment of Muscle Pain Induced by Eccentric Exercise
1. Comparison of the effect of ketoprofen Transfersome® gel (KTG) to placebo gel (PG) on muscle pain of the calf caused by eccentric contractions 2.
- Trial name
- NCT01020279
- Testing
- Celecoxib, Ketoprofen, Ketoprofen
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- X-pert Med GmbH
Bone Loss, Alveolar Bone Resorption
Biomaterial Clinical Performance in a Socket Preservation Model
When a dental extraction is performed, sequential cascade of events happens that lead to a modeling and remodeling of the area. This phenomenon leads to bone resorption and consequential volume loss atrophy.
- Trial name
- NCT04789759
- Testing
- Socket Preservation - Bond Apatite synthetic bone substitute, Socket healing - No Filler
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- International Advanced Dentistry, Lisbon
Anterior Cruciate Ligament Injuries
Individualized Anterior Cruciate Ligament Versus Conventional Reconstruction
A randomised prospective control trial comparing the efficiency of a more individualized approach in ACL reconstruction with the help of neuromuscular computer models with traditional ACL reconstruction practices.
- Trial name
- IACLR (NCT04366362)
- Testing
- Individualised ACL reconstruction, Conventional ACL reconstruction
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Musculoskeletal Pain
Test-Retest Reliability of an Experimental Model of Shoulder Muscle Pain
High frequency oscillations of non-ionizing electromagnetic fields range can heat deep tissues in a well-localized region. Recently, a new SWD-based model showed to be a promising tool for investigating muscle pain in humans.
- Trial name
- NCT05412316
- Testing
- Intervention: Short-wave diathermy
- Where
- Argentina
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario
Patellofemoral Pain Syndrome
Treatment Effects on Neuromuscular Properties on Young Women Symptomatic for Patellofemoral Pain Syndrome
Patellofemoral Pain Syndrome (PFPS) is characterized by diffuse pain around the knee joint. This presence of pain is the most common manifestation in sports medicine among adults and young people.
- Trial name
- NCT03663595
- Testing
- Model 1, Model 2
- Where
- Brazil
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Arthritis, Gout
Phone-Based Based Walk With Ease Program for Adults With Arthritis
The objective of this study is to examine the short-term (6-weeks and 6 months) and long-term (1 year) effects of a phone-based version of Walk With Ease intervention.
- Conditions
- Arthritis, Gout, Fibromyalgia, Rheumatoid Arthritis
- Trial name
- NCT05289544
- Testing
- Phone-Based Walk With Ease
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Kyphosis
Study of Spino-pelvic Sagittal Balance by Vicon® Optoelectronic System
Spinal diseases often induce gait disorders with multifactorial origins such as lumbar pain, radicular pain, neurologic complications, or spinal deformities.
- Trial name
- VICON-SPINE (NCT03536403)
- Testing
- EOS X-rays, 8-meters walk test
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Bone Loss, Regenerative Inflammation
Osteogenic Action of a Biphasic Bioceramic With Statin in a Third Molar Extraction Model
The clinical study aims to assess the osteogenic effects of Galibone+ in bone regeneration post-extraction of impacted mandibular third molars.
- Trial name
- Galibone (NCT06338241)
- Testing
- Biphasic bioceramic of tricalcium phosphate and hydroxyapatite with simvastatin, Bovine Hydroxyapatite
- Where
- 2 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mario Pérez Sayáns
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Musculoskeletal Function
Immediate Effects of Calf and Plantar Fascia Manual Therapy
This study investigated the immediate effects of two manual therapy approaches, myofascial release and the fascial distortion model, applied to the calf and plantar fascia in healthy adults.
- Trial name
- NCT07319507
- Testing
- Myofascial Release, Fascial Distortion Model
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- JiYoung Kim
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Osteoporosis, University Students
Awareness Model in Prevention of Osteoporosis
This study investigated the effectiveness of a Healthy Living Awareness Program for the Prevention of Osteoporosis based on the Information-Motivation-Behavioral Skills Model (HLAPPO-IMB) in university students.
- Conditions
- Osteoporosis, University Students, Healthy Lifestyle
- Trial name
- NCT06028243
- Testing
- The Healthy Living Awareness Program for the Prevention of Osteoporosis (HLAPPO-IMB)- Information stage, The Healthy Living Awareness Program for the Prevention of Osteoporosis (HLAPPO-IMB)- Motivation stage, The Healthy Living Awareness Program for the Prevention of Osteoporosis (HLAPPO-IMB)- Behavior skills stage
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University