Clinical trials: Musculoskeletal Model
Bloodstream Infection, Pneumonia, Bacterial
Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized Patients
DETERMINE trial is a prospective multicenter multinational cohort study. This study will be carried out to predict the risk of bloodstream infections (BSIs) or other types of invasive infection with carbapenem resistant…
- Conditions
- Bloodstream Infection, Pneumonia, Bacterial, Intra-abdominal Infection, Urinary Tract Infections
- Trial name
- DETERMINE (NCT04229511)
- Testing
- Detection of CRKp colonization
- Where
- Turkey (Türkiye)
- Volunteers
- 520 people
- Sponsor
- SCARE (Study group for carbapenem resistance)
Musculoskeletal Pain, Healthy
Multivariable Recovery After Exercise-induced Muscle Pain in the Forearm Muscles
This study investigates the evolution of sensory, motor and tissue variables following exercise-induced pain in wrist extensor muscles in healthy subjects.
- Conditions
- Musculoskeletal Pain, Healthy, Delayed Onset Muscle Soreness
- Trial name
- NCT04012203
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Musculoskeletal Pain
Study of Epicutaneously Applied Ketoprofen Transfersome® Gel With or Without Combination With Oral Celecoxib for the Treatment of Muscle Pain Induced by Eccentric Exercise
1. Comparison of the effect of ketoprofen Transfersome® gel (KTG) to placebo gel (PG) on muscle pain of the calf caused by eccentric contractions 2.
- Trial name
- NCT01020279
- Testing
- Celecoxib, Ketoprofen, Ketoprofen
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- X-pert Med GmbH
Bone Loss, Alveolar Bone Resorption
Biomaterial Clinical Performance in a Socket Preservation Model
When a dental extraction is performed, sequential cascade of events happens that lead to a modeling and remodeling of the area. This phenomenon leads to bone resorption and consequential volume loss atrophy.
- Trial name
- NCT04789759
- Testing
- Socket Preservation - Bond Apatite synthetic bone substitute, Socket healing - No Filler
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- International Advanced Dentistry, Lisbon
Anterior Cruciate Ligament Injuries
Individualized Anterior Cruciate Ligament Versus Conventional Reconstruction
A randomised prospective control trial comparing the efficiency of a more individualized approach in ACL reconstruction with the help of neuromuscular computer models with traditional ACL reconstruction practices.
- Trial name
- IACLR (NCT04366362)
- Testing
- Individualised ACL reconstruction, Conventional ACL reconstruction
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Knee Osteoarthritis, Total Knee Arthroplasty
Prediction of Postoperative Outcomes After TKA Using Instrumented Insoles and DNN
This multicenter prospective observational study aims to evaluate whether preoperative clinical variables and wearable sensor-derived gait features can predict postoperative improvement after total knee arthroplasty (TKA).
- Trial name
- NCT07367789
- Testing
- Instrumented Insole Gait Assessment
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Psychological Stress, Cardiopulmonary Bypass Surgery
CARINAE for Stress Relief in Perioperative Care
Preventing pre-surgical stress can help patients achieve positive outcomes on health and well-being. However, very few patients receive adequate stress relief support prior to a surgical procedure.
- Conditions
- Psychological Stress, Cardiopulmonary Bypass Surgery, Coronary Artery Bypass Surgery, Cardiac Valve Replacement
- Trial name
- CARINAE (NCT05184725)
- Testing
- SaMD CARINAE
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Adhera Health, Inc.
Juvenile Idiopathic Arthritis (JIA)
Development of a Multidimensional Prediction Model for the Course and Outcome of Early-Onset Juvenile Idiopathic Arthritis (JIA)
This is a prospective-retrospective, translational, no profit, multicentric, observational study. A cohort of at least 100 early-onset JIA patients attending the Unit of Rheumatology and Autoinflammatory Diseases, Department of…
- Trial name
- NCT07882667
- Where
- 2 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Istituto Giannina Gaslini
Neurological Disorders, Orthopedic Disorders
A Model for Continuous Care of Fragile Patients
This observational study aims to monitor functional status and identify potential declines in the functioning of medically fragile patients with neurological and/or orthopedic conditions, representing an added value for ensuring…
- Conditions
- Neurological Disorders, Orthopedic Disorders, Functional Decline, Fragile and More Vulnerable
- Trial name
- AFTER (NCT07299344)
- Testing
- Telemedicine-Based Functional Monitoring
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Sanitaria Locale CN2 Alba-Bra
Musculoskeletal Pain
Test-Retest Reliability of an Experimental Model of Shoulder Muscle Pain
High frequency oscillations of non-ionizing electromagnetic fields range can heat deep tissues in a well-localized region. Recently, a new SWD-based model showed to be a promising tool for investigating muscle pain in humans.
- Trial name
- NCT05412316
- Testing
- Intervention: Short-wave diathermy
- Where
- Argentina
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario
Osteoarthritis, Knee
Personalised Modeling and Simulations for the Differential Diagnosis of Dynapenia: Study on Patients With Osteoarthritis
The ForceLoss study aims to develop personalised modeling and simulation procedures to enable the differential diagnosis for the loss of muscle force, namely dynapenia.
- Trial name
- ForceLoss II (NCT05795348)
- Testing
- Personalised Musculoskeletal Modeling
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Patellofemoral Pain Syndrome
Treatment Effects on Neuromuscular Properties on Young Women Symptomatic for Patellofemoral Pain Syndrome
Patellofemoral Pain Syndrome (PFPS) is characterized by diffuse pain around the knee joint. This presence of pain is the most common manifestation in sports medicine among adults and young people.
- Trial name
- NCT03663595
- Testing
- Model 1, Model 2
- Where
- Brazil
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Arthritis, Gout
Phone-Based Based Walk With Ease Program for Adults With Arthritis
The objective of this study is to examine the short-term (6-weeks and 6 months) and long-term (1 year) effects of a phone-based version of Walk With Ease intervention.
- Conditions
- Arthritis, Gout, Fibromyalgia, Rheumatoid Arthritis
- Trial name
- NCT05289544
- Testing
- Phone-Based Walk With Ease
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Growth Hormone Deficiency
Development and Validation of a Self-assessment System Based on a Mobile App to Manage Adult Growth Hormone Deficiency
Adult Growth Hormone Deficiency (AGHD) is a recognized clinical entity but several barriers concerning patient-clinician communication, inadequate patients' awareness of the disease, low perceived benefit of replacement therapy…
- Trial name
- GrASS (NCT03525587)
- Testing
- Use of "MAGHD App/MAGHD Framework"
- Where
- Italy
- Volunteers
- 83 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Knee Osteoarthritis, Joint Disease
Multimodal Imaging of Subchondral Bone in Knee Osteoarthritis : Predictive Model
Predictive factors of osteoarthritis progression are not yet well understood. However, a growing role attaches importance to the subchondral bone.
- Conditions
- Knee Osteoarthritis, Joint Disease, Arthritis, Musculoskeletal Disease
- Trial name
- MOSART (NCT03294408)
- Testing
- multimodal imaging
- Where
- 2 sites in France
- Volunteers
- 167 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Kyphosis
Study of Spino-pelvic Sagittal Balance by Vicon® Optoelectronic System
Spinal diseases often induce gait disorders with multifactorial origins such as lumbar pain, radicular pain, neurologic complications, or spinal deformities.
- Trial name
- VICON-SPINE (NCT03536403)
- Testing
- EOS X-rays, 8-meters walk test
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Ambulatory Surgery, Laparoscopy
Implementation of 23 Hour Surgery Model in a Tertiary Hospital
Extended day surgery or 23 h surgery (23-hour surgery) is a surgical model where patients arrive to the hospital from home at the day of surgery, are operated and recover in a 23 h surgery unit.
- Conditions
- Ambulatory Surgery, Laparoscopy, Shoulder Impingement Syndrome, Ovarian Cysts
- Trial name
- Herko (NCT04142203)
- Testing
- 23 h surgery
- Where
- Finland
- Volunteers
- 993 people
- Sponsor
- Kuopio University Hospital
Bone Loss, Regenerative Inflammation
Osteogenic Action of a Biphasic Bioceramic With Statin in a Third Molar Extraction Model
The clinical study aims to assess the osteogenic effects of Galibone+ in bone regeneration post-extraction of impacted mandibular third molars.
- Trial name
- Galibone (NCT06338241)
- Testing
- Biphasic bioceramic of tricalcium phosphate and hydroxyapatite with simvastatin, Bovine Hydroxyapatite
- Where
- 2 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mario Pérez Sayáns
Depression, Anxiety
Effects of an Integrative Treatment Model to Reduce Anxiety and Depression in Minor Mental Health Problems and Medically Unexplained Symptoms
Minor mental health problems, MMHP, like mild depression and anxiety, and medically unexplained symptoms, MUS, symptoms with no known underlying organic disease, are strongly associated to each other.
- Conditions
- Depression, Anxiety, Irritable Bowel Syndrome, Fibromyalgia
- Trial name
- NCT01631500
- Testing
- Conventional treatment, Integrative treatment, Therapeutic acupuncture
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Göteborg University
Acute Kidney Injury, Crush Injury
The Effects of Dexmedetomidine and Remifentanil on Kidney Injury After Muscle Compression Injury in Rats
The goal of this interventional preclinical study is to evaluate the potential protective effects of two intravenous anesthetic agents-dexmedetomidine and remifentanil-on kidney function in the context of muscle crush injury…
- Conditions
- Acute Kidney Injury, Crush Injury, Rhabdomyolysis
- Trial name
- NCT07094165
- Testing
- Dexmedetomidine, Remifentanil, Laparotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara City Hospital Bilkent