Clinical trials: Musculoskeletal Pain
Osteoarthritis, Rheumatoid Arthritis
Web-based Support to Manage Arthritis Pain
Development of an interactive, online pain self-management program for adults who suffer from pain associated with osteoarthritis, rheumatoid arthritis, Ankylosing spondylitis, and other arthritic conditions (e.g., psoriatic…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Other Arthritic Conditions (e.g., Psoriatic Arthritis)
- Trial name
- NCT01463189
- Testing
- painACTION: Arthritis
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Inflexxion, Inc.
Exercise-induced Joint Pain Stiffness and Cartilage Turnover
NEM® Versus Placebo on Exercise-induced Joint Pain, Stiffness, & Cartilage Turnover In Healthy, Post-Menopausal Women
This study is intended to evaluate the effect of the dietary supplement NEM® brand eggshell membrane versus placebo in reducing exercise-induced joint pain \& stiffness \& cartilage turnover in healthy post-menopausal women.
- Trial name
- NCT02751944
- Testing
- NEM
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Bone Metastases
ExAblate Conformal Bone System Treatment of Metastatic Bone Tumors for the Palliation of Pain
A study to evaluate the safety and initial effectiveness of the ExAblate 2100 Conformal Bone System in the treatment of pain resulting from metastatic bone tumors.
- Trial name
- NCT00981578
- Testing
- ExAblate 2100
- Where
- 5 sites in United States
- Volunteers
- 37 people
- Sponsor
- InSightec
Osteoarthritis
Study of Meloxicam Capsules to Treat Osteoarthritis Pain
The purpose of this study is to determine whether Meloxicam [Test] Capsules are safe and effective for the treatment of osteoarthritis pain of the knee or hip.
- Trial name
- NCT01787188
- Testing
- Meloxicam Test Capsules
- Where
- 40 sites in United States
- Volunteers
- 403 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Osteoarthritis, Knee
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
This is a multi-center, randomized, double-blind, parallel group, placebo controlled trial to compare the safety and effectiveness of a single injection of Cingal® to a single injection of Triamcinolone Hexacetonide (TH) to…
- Trial name
- NCT04231318
- Testing
- Cingal, Triamcinolone Hexacetonide (TH)
- Where
- 26 sites in United States
- Volunteers
- 231 people
- Sponsor
- Anika Therapeutics, Inc.
Non-radiographic Axial Spondyloarthritis
Efficacy and Safety Study of Secukinumab in Chinese Participants With Non-radiographic Axial Spondyloarthritis
The purpose of this study was to evaluate the efficacy, safety, and tolerability of secukinumab in Chinese patients with active non-radiographic axial spondyloarthritis (nr-axSpA).
- Trial name
- NCT04732117
- Testing
- Secukinumab
- Where
- 29 sites in China
- Volunteers
- 137 people
- Sponsor
- Novartis Pharmaceuticals
Pain Associated With Fibromyalgia
Treatment of Pain Associated With Fibromyalgia
The main objective of this trial is to compare change in weekly average daily pain score (ADPS) from baseline to Week 13 in participants receiving either dose of DS-5565 versus placebo.
- Trial name
- NCT02187159
- Testing
- DS-5565, Pregabalin
- Where
- 176 sites in United States, Australia and 10 more
- Volunteers
- 1,270 people
- Sponsor
- Daiichi Sankyo
Postoperative Pain
A Study of TLC590 for Postsurgical Pain Following Bunionectomy
This is a Phase 3, randomized, double-blind, comparator- and placebo-controlled study to evaluate analgesic efficacy and safety of TLC590 via local infiltration in adult subjects following bunionectomy.
- Trial name
- NCT07222748
- Testing
- TLC590, Liposomal Bupivacaine
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- TLC Biopharmaceuticals, Inc.
Knee Osteoarthritis
Symptomatic Efficacy of Diacerein in Knee Osteoarthritis
Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis.
- Trial name
- NCT00445276
- Testing
- Diacerein
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Laboratoires NEGMA
Osteoarthritis
TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis
This study will evaluate the efficacy and safety of intra-articular injections of 20 mg/2mL dose HYALGAN in patients with pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT00130468
- Testing
- Hyalgan (sodium hyaluronate)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Sanofi
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Fibromyalgia
A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily in Patients With Fibromyalgia
This is a Phase 3, randomized, parallel-group, double-blind, placebo-controlled, 14-week study designed to evaluate the efficacy and safety of TNX-102 SL 5.6 mg (2 x 2.8 mg tablets) taken daily at bedtime for the treatment of…
- Trial name
- RESILIENT (NCT05273749)
- Testing
- TNX-102 SL Tablet, 5.6 mg
- Where
- 33 sites in United States
- Volunteers
- 457 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Low Back Pain, Musculoskeletal Pain
Connective Tissue Motion Measure 2
This study aims to compare the Connective Tissue Motion Measure (CTMM) in low back pain and no-low back pain subjects, evaluate the reliability of the CTMM, and examine the correlation of CTMM with low back pain symptoms…
- Trial name
- NCT01784094
- Testing
- StromaGlide
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Stromatec, Inc.
Tendon Injuries
A Methodology Study to Assess Muscle Damage After Eccentric Exercise
An isolated bout of unaccustomed maximal eccentric exercise is associated with muscle force loss for 2-4 days, mild reversible muscle tenderness, and ultra-structural damage to the muscle fibers, elevation of muscle proteins in…
- Trial name
- NCT02014662
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis (RA)
Treatment With Auricular Vagus Nerve Stimulation in Rheumatoid Arthritis - the TRAVAGA Study
Purpose and aim The overall aim is to investigate efficacy and safety of a newly developed non-invasive auricular investigational device that electrically stimulates the auricular branch of the vagus nerve to activate the…
- Trial name
- TRAVAGA (NCT06779123)
- Testing
- Transauricular vagus nerve stimulation., transauricular vagus nerve non-stimulation
- Where
- 6 sites in Sweden
- Volunteers
- 128 people
- Sponsor
- taVNS AB
Lumbar Disc Herniation, Annular Disc Tear
A Post Marketing Surveillance Study
This study is a prospective, multi-center study to monitor the early safety and performance of one iteration of the Barricaid Anular Closure Device (ACD) - 6mm anchor width, when used as an adjunct to limited discectomy.
- Conditions
- Lumbar Disc Herniation, Annular Disc Tear, Annular Tear of Lumbar Disc
- Trial name
- 6MM (NCT03366779)
- Testing
- 6mm annular closure device
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 20 people
- Sponsor
- Intrinsic Therapeutics
Breast Cancer
Effect of Sukshma Vyayama Yoga on Aromatase Inhibitor-Induced Arthralgia in Breast Cancer Survivors
The purpose of this study is to investigate the efficacy of sukshma vyayama joint loosening yoga in improving aromatase inhibitor-induced arthralgia in post-menopausal breast cancer survivors and secondarily, to evaluate the…
- Trial name
- NCT04042870
- Testing
- Joint Loosening Yoga
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- AshtaYoga, LLC
Degenerative Spondylolisthesis
Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion
Ankasa Regenerative Therapeutics, Inc. (Ankasa) is developing ART352-L, a liposomal formulation of recombinant human Wnt3A protein, that is applied ex vivo, to harvested autologous bone grafts (autograft) to enhance the…
- Trial name
- NCT04378543
- Testing
- ART352-L
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Ankasa Regenerative Therapeutics, Inc.