Clinical trials: Musculoskeletal System
Axial Spondyloarthritis, Arthritis, Rheumatoid
The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA
Spondyloarthritis (SpA) and Rheumatoid arthritis (RA) are among the most common chronic inflammatory rheumatic diseases. Introduction of Tumor Necrosis Factor alpha inhibitors (TNFi) to the therapeutic strategy improved acute…
- Trial name
- MicroSpA & RA (NCT04973787)
- Testing
- biological disease-modifying antirheumatic drugs (bDMARDs)
- Where
- 10 sites in Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME
Progressive Muscle Relaxation According to Jacobson in Treatment of the Patients With Temporomandibular Joint Disorders
Temporomandibular joint disorders are ranked third among the most common stomatological diseases after dental caries and periodontal problems.
- Trial name
- NCT03622684
- Testing
- Muscle relaxation according to Jacobson
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Musculoskeletal Pain, Sedentary Behavior
Multidisciplinary Health Monitoring for Esports Players
This study aims to develop a holistic, multidisciplinary health monitoring/screening module that evaluates the health and performance parameters of esports players, and to apply and assess the effectiveness of an individualized…
- Conditions
- Musculoskeletal Pain, Sedentary Behavior, Diet Habit, Physiological Stress
- Trial name
- NCT07665333
- Testing
- Multidisciplinary Preventive Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Hallux Valgus, Pain
Effects of Hallux Valgus Deformity on Rear Foot Position, Pain, Function, and Quality of Life in Women
To investigate relationship between HV deformity and position of rearfoot joints, and its effects on the quality of life, pain, and related functional status in women with bilateral hallux valgus (HV).
- Trial name
- NCT01989338
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Fibromyalgia
Risk Factors of Primary Fibromyalgia
Fibromyalgia (FM) is a condition with a different non-specific symptoms which lead to a difficult diagnosis. Study suggests that osteopathy can help in improving FM symptoms, nevertheless, it can be difficult to identify which…
- Trial name
- NCT05295316
- Testing
- Life Stressor Checklist Revised (LSC-R) (Appendix 1)
- Where
- Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Studio Osteopatico Busto Arsizio
Jaw, Edentulous, Partially, Dental Implants, Single-tooth
Long-term Effectiveness of Contour Augmentation in Sites With Early Implant Placement
In this prospective case series study, 20 patients with an implant-borne single crown following early implant placement with simultaneous contour augmentation will be followed for 10 years.
- Conditions
- Jaw, Edentulous, Partially, Dental Implants, Single-tooth, Grafting Bone
- Trial name
- NCT03252106
- Testing
- Contour augmentation with implant placement
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bern
Compartment Syndrome
Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg
An investigation of a new catheter and pressure monitor system that may help to prevent a complication called compartment syndrome from developing in an injured leg.
- Trial name
- TS2 (NCT00681616)
- Testing
- Compartment Monitoring System (CMS), Compartment Monitoring System with Active Fluid Removal, Compartment Monitoring System without fluid removal
- Where
- 13 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Twin Star Medical, Inc.
Posture
The Effects of a Customized Exercise Program on Pain, Kyphosis Angle, and Quality of Life
The aim of this study is to evaluate the effect of a customized corrective exercise program on back pain, kyphosis degree, and quality of life in healthy adults.
- Trial name
- Exercise (NCT07477847)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Rumeli University
PFP, Patellofemoral Pain
The Role of Arthrogenic Muscular Inhibition in Patellofemoral Pain and the Response to an Exercise Programme
Patellofemoral pain (PFP) is the most diagnosed condition in individuals with knee complaints. Studies revealed that one third of individuals with PFP suffer from persistent complaints, indicating that current treatments fail to…
- Conditions
- PFP, Patellofemoral Pain, Anterior Knee Pain
- Trial name
- PFP-Inhibit (NCT02786784)
- Testing
- 6 week exercise treatment
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Salford
Psoriasis, Coronary Artery Disease
Premature Coronary Artery Disease (CAD) in Severe Psoriasis
The purpose of this study is to compare the prevalence and severity of CAD (coronary artery disease) in patients with and without severe psoriasis, otherwise matched for cardiovascular risk factors.
- Trial name
- NCT00893126
- Testing
- CCTA Scan (Coronary CT Angiogram)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stroke, Spasticity, Muscle
Robotic Interventions for Spasticity Treatment
The researchers have developed games controlled by electromyographic (EMG) and inertial measurement unit (IMU) activity recorded by a sensor.
- Trial name
- NCT05006248
- Testing
- Conventional robotic continuous passive movement training, Visual Feedback, Haptic and Visual Feedback
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Osteoarthritis, Degenerative Joint Disease
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement
The purpose of this study is to clarify the efficacy of a multidrug versus single drug periarticular injection when only standard operative and postoperative pain management protocols used and the control group is exposed to what…
- Trial name
- NCT03119038
- Testing
- Bupivicaine + epinephrine, Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Pain, Delayed Onset Muscle Soreness
Phase II Study of AP0302 5% Versus a Vehicle Comparator
This study is designed to evaluate the analgesic safety and efficacy of study drug (AP0302) applied topically every 6 hours as compared to a vehicle, in subjects experiencing delayed onset muscle soreness.
- Trial name
- NCT02324985
- Testing
- S-Ibuprofen Topical Gel 5%, Vehicle Topical Gel
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Aponia Laboratories, Inc.
Joint Discomfort, Joint Pain, Stiffness, Function
JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal Women
The goal of this interventional study is to evaluate whether the study product can help improve quality of life and reduce common menopause symptoms-such as joint discomfort, hot flashes and night sweats-in women aged 50-70.
- Conditions
- Joint Discomfort, Joint Pain, Stiffness, Function, Joint Pain, Hot Flashes
- Trial name
- NCT07238478
- Testing
- JDS-HF3.0
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Atrophic Maxilla, Partial Edentulism
Prospective Study of Bone Augmentation With Lateral Sinus Lift and Osseointegration of Dental Implants
By using a split-mouth model in the maxilla, lateral sinus lift procedures will be performed using xenograft on one side vs autologous bone augmentation and PRF membranes on the other side.
- Trial name
- NCT07014085
- Testing
- "Histomorphometric Evaluation of Bone Augmentation Using Xenografts Versus Autologous Bone Grafts in Dental Implant Patients: A Comparative Clinical Study
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maria H. Pham
Spasticity
Prevalence of Spasticity in Veterans Living in a Long-term Care Facility
The purpose of the study is to conduct a feasibility survey of the prevalence of spasticity at a single long-term care facility for veterans and their spouses in Murfreesboro, Tennessee.
- Trial name
- NCT01879449
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
TEMPOROMANDIBULAR JOINT DISEASES
ANS Effects of ULF-TENS Stimulation in Patients With and Without TMD
Using computerized pupillometry, previous research established that the autonomic nervous system (ANS) is dysregulated in patients who suffer from temporomandibular disorders (TMDs), suggesting a potential role for ANS…
- Trial name
- NCT02789085
- Testing
- ULF TENS stimulation
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Contracture, Hand
Effects of Paraffin Wax Therapy vs METs in Post Burn Hand Contractures
The degree of the burn and the rate of scar development during healing are the main determinants of loss of hand function following thermal injury.
- Trial name
- NCT06198062
- Testing
- Paraffin wax bath therapy, Paraffin Wax Bath Therapy and Muscle Energy Techniques
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Rheumatoid Arthritis
A Study of BMS-986195 in Healthy Male Subjects
The purpose of this study is to investigate the effects BMS-986195 in healthy male subjects.
- Trial name
- NCT03245515
- Testing
- BMS-986195
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Trigger Finger Disorder
Long Term Effectiveness of Trigger Finger Injections With Triamcinolone vs. Dexamethasone
Trigger finger (stenosing tenosynovitis) is a very common condition and in office treatment with corticosteroid injection is widely accepted to be first line treatment.
- Trial name
- NCT03641508
- Testing
- Triamcinolone, Dexamethasone
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Ericka Lawler
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