Clinical trials: Musculoskeletal System
Osteoarthritis, Knee
NEO6860, a TRPV1 Antagonist, First in Human Study
This study is a double blind, placebo controlled, ascending single and multiple oral dose study conducted in two parts, aimed at determining the safety and tolerability of single and multiple oral doses of NEO6860 in healthy…
- Trial name
- NCT02337543
- Testing
- NEO6860
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Neomed Institute
Muskuloskeletal Diseases, Healthy
Proton MRI of MSK Disorders
In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs.
- Conditions
- Muskuloskeletal Diseases, Healthy, Respiratory
- Trial name
- NCT07845708
- Testing
- MRI
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laura Walkup
Periodontitis, Localized Aggressive, Periodontal Diseases
Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket
The aim of this study is to evaluate the accuracy of pulp test in teeth presenting with deep periodontal pocket. The null hypothesis is no significant effect of periodontitis on the accuracy of pulp test.
- Conditions
- Periodontitis, Localized Aggressive, Periodontal Diseases, Endodontic Disease, Endodontic Inflammation
- Trial name
- NCT04399135
- Testing
- Orthopantomogram X-ray view, Endo-Ice, Electric Pulp Tester (EPT)
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Qassim University
Sjogren's Syndrome
Implantology and Sjögren's Syndrome
Until now it has not been investigated whether placement of implants in SS patients is less successful than compared to non-SS patients.
- Trial name
- NCT02661243
- Testing
- Biohorizons Laser-lok bonelevel dental implants
- Where
- 5 sites in Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Derk Jan Jager
Joint Hypermobility, Femoral Anteversion
The Effect of Lower Extremity Rotational Profile on Postural Control, Muscle Strength, Functional Capacity and Lower Extremity Function in Children With Generalized Joint Hypermobility
Generalized joint hypermobility is when the range of motion in synovial joints exceeds its physiological limits. The aim of this investigation is to investigate the effect of lower extremity rotational profile on postural…
- Conditions
- Joint Hypermobility, Femoral Anteversion, Postural Control, Lower Extremity Muscle Strength
- Trial name
- NCT06998563
- Testing
- Rotational Profile- Hip Internal and External Rotation Measurement, Rotational Profile- Craig's Test Measurement, Rotational Profile- Foot/Thigh Angle Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Osteoarthritis, Knee
Mobilizing Hispanics With Knee Osteoarthritis
The objective is to conduct an early-stage clinical trial in order to provide data required to support a future clinical trial to demonstrate the effectiveness of a culturally acceptable treatment program to increase exercise and…
- Trial name
- NCT06522906
- Testing
- Muscle Strengthening, General Physical Activity, Education
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Prenatal Care, Walking
Effects of Nordic Walking on Prenatal Health
This randomized controlled trial (RCT) aimed to evaluate the effects of Nordic walking (NW) on gait kinematics, musculoskeletal pain, and quality of life in pregnant women.
- Trial name
- Nordic Walking (NCT06673147)
- Testing
- Prenatal Nordic Walking
- Where
- Saudi Arabia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Jazan
Sarcopenia, Juvenile Idiopathic Arthritis
Sarcopenia in Children
Juvenile idiopathic arthritis (AJI), is a frequent inflammatory disease in children, characterized by pain, arthritis, and deformities.
- Trial name
- NCT05291416
- Testing
- densitometry/ handgrip dynamometer
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Musculoskeletal Injury, Injury, Knee
Effects of App-based Versus Personal On-site Instruction on Neuromuscular Activity in Injury Prevention Exercises
Therefore, the aim of the present study was to evaluate neuromuscular characteristics observed during a single bout of selected and validated injury preventive exercises instructed by an app (in accordance with 'Get set - Train…
- Trial name
- ACL01 (NCT03063814)
- Testing
- APP, PHY
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Muscle Disuse Atrophy
Muscle Damage and Disuse Atrophy
Limb injury generally requires a period of recovery during which time the limb is often immobilised (e.g. with a cast or brace) resulting in a rapid loss of skeletal muscle.
- Trial name
- NCT03559452
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hip Osteoarthritis, Knee Osteoarthritis
Determining the Impact of a Physiotherapist-Led Primary Care Model for Hip and Knee Pain - A Pilot Trial
This is a pilot cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada.
- Trial name
- NCT05736133
- Testing
- Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Jordan Miller, PT, PhD
Cancer, Remission
Testing an Herbal Pain Relief Patch to Reduce Pain in Cancer Survivors
The purpose of this study is to find out whether Tibetree Pain Relieving Plaster, an herbal pain relief patch, may be able to reduce this pain.
- Trial name
- NCT04916249
- Testing
- Tibetree Pain Relieving Plaster
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Knee Osteoarthritis, Limitation, Mobility
The Effect of Graded Motor Imagery on Pain and Function in Individuals With Knee Osteoarthritis
The aim of this study is to investigate whether Graded Motor Imagery (GMI) application is as effective as Transcutaneous Electrical Nerve Stimulation (TENS) in individuals with knee osteoarthritis (OA).
- Trial name
- NCT05925517
- Testing
- Graded Motor Imagery (GMI), Transcutaneous Electrical Nerve Stimulation (TENS), Conventional Physiotherapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Artvin Coruh University
Knee Osteoarthritis
Effects of Bracing on Knee Osteoarthritis (OA)
Knee osteoarthritis (OA) is characterized by complaints of knee pain, aching and stiffness that commonly alter the way one will climb stairs and walk reducing an individual's function and the activities they may perform on a…
- Trial name
- NCT01886144
- Testing
- Knee OA Brace
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Arthritis
A Comparison of the ASHC and CDSMP
The arthritis-specific Arthritis Self Help Course (ASHC) and the more generic Chronic Disease Self Management Program (CDSMP) teach generalizable skills for managing arthritis and other chronic diseases.
- Trial name
- NCT00207415
- Testing
- ASHC and CDSMP
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Pes Planus
Balance, Plantar Pressure Distribution and Gait in Pes Planus
Introduction:The results of studies evaluating balance, plantar pressure analysis, and gait in adults with pes planus have differed in the literature.
- Trial name
- NCT05240287
- Testing
- Navicular Drop Test, Foot Posture Index, Balance
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Baskent University
Osteoporosis
Safety and Effectiveness of Soy Phytoestrogens to Prevent Bone Loss
The purpose of this study is to determine whether soy isoflavone supplementation is safe and effective to prevent bone loss in postmenopausal women.
- Trial name
- OPUS (NCT00665860)
- Testing
- Soy isoflavones
- Where
- 3 sites in United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Gout
D-0120 Safety and PK/PD, Food Effect Study in Healthy Volunteers
This initial clinical study in the US will be a randomized, double-blind, placebo-controlled, single-dose, dose-escalation, and sequential cohort study to evaluate the safety, tolerability, PK and PD of D-0120-NA in fasting…
- Trial name
- NCT03291782
- Testing
- D-0120
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- InventisBio Co., Ltd
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
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