Clinical trials: Musculoskeletal System
Myofascial Pain, Neck Pain
Dry Needling vs Dry Needling With ES in Patients With Neck/Shoulder Pain
First, we aim to determine if there is a difference in the rate of improvement, as measured by the Neck Disability Index (NDI) and Numerical Pain Rating Scale (NPRS), across a 6 week treatment period between those treated with DN…
- Conditions
- Myofascial Pain, Neck Pain, Shoulder Pain
- Trial name
- NCT03638388
- Testing
- Dry needling (DN), Dry needling with intramuscular electrical stimulation (DNES)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kindyle Brennan
Spasticity, Muscle, Muscular Diseases
Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity
The purpose of this study is to improve spasticity diagnosis through development of a simple physical examination guide for primary care providers to identify patients who would benefit from being referred to a movement disorders…
- Conditions
- Spasticity, Muscle, Muscular Diseases, Musculoskeletal Disease, Muscle Hypertonia
- Trial name
- NCT03209960
- Testing
- Bedside Referral Tool, Neurological Examination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Lateral Epicondylitis
Efficacy Study of Prolotherapy vs Corticosteroid for Tennis Elbow
The purpose of the research is to study the effects of two different injection therapies for the treatment of lateral epicondylitis (tennis elbow).
- Trial name
- NCT00160303
- Testing
- Prolotherapy, Local Corticosteroid Therapy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Plantar Fasciitis, Chronic, Tibial Nerve
Tibial Nerve Size and Clinical Features in Chronic Plantar Fasciitis
This cross-sectional observational study aims to examine the relationship between tibial nerve cross-sectional area at the tarsal tunnel and plantar fascia thickness, pressure pain threshold, foot posture, and functional status…
- Trial name
- NCT07878273
- Testing
- Pressure Pain Threshold Assessment, Plantar fascia ultrasonographic Assessment, Tibial nerve ultrasonographic assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Fatigue
Role of Artificial Intelligence in Predicting Muscle Fatigue Using Virtual Reality Training
The goal of this observational predicted study is to predict muscle fatigue using a specific AI algorithm in healthy vs post Covid-19 infected individuals.
- Trial name
- NCT05813613
- Testing
- Squatting with the aid of Kynapsis Virtual Training apparatus.
- Where
- Lebanon
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beirut Arab University
Muscle Weakness, XLH
Muscle Abnormalities in Children With XLH
XLH rickets is a rare disease with muscle weakness. Fat parameters such as IMAT and intraMAT could be increased in this disease.
- Trial name
- MDmuscleXLH (NCT05312086)
- Testing
- MRI
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Psoriatic Arthritis
Treatment With Apremilast in Patients With Psoriatic Arthritis
Apremilast (Otezla®) is a Federal Drug Administration (FDA)-approved treatment for psoriatic arthritis and psoriasis. Although there are a lot of data demonstrating how apremilast works in the laboratory, there are very few…
- Trial name
- NCT02558361
- Testing
- Treatment with Apremilast
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of South Florida
Scoliosis, Scoliosis Kyphosis
Effect of Adult Spinal Deformity Surgery on Functional Reach
Adult spinal deformity (ASD) is a common spinal condition that often impacts an individual's ability to stand and maintain an upright posture.
- Trial name
- NCT06258161
- Testing
- Spinal Fusion, No intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Systememic Lupus Erythematosus, Systemic Sclerosis (SSc)
Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I Interferonopathies
Systemic autoimmune diseases associated with type I interferon (IFN-I) dysregulation, such as systemic lupus erythematosus, systemic sclerosis, myositis, and mixed or undifferentiated connective tissue diseases, and genetic type…
- Conditions
- Systememic Lupus Erythematosus, Systemic Sclerosis (SSc), Inflammatory Myopathies, Connective Tissue Diseases
- Trial name
- SAFRAN (NCT07837986)
- Testing
- biological samples
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Rheumatoid Arthritis (RA), Inflammatory Bowel Disease - IBD1
Phase I Clinical Study of ZL-82 Tablets
ZL-82 is an oral janus kinase (JAK) inhibitor. In vitro biological mass spectrometry identification test proves that ZL-82 can selectively and irreversibly inhibit JAK3.
- Trial name
- NCT06055023
- Testing
- ZL-82 12.5mg, ZL-82 25mg, ZL-82 50mg
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Chengdu Zenitar Biomedical Technology Co., Ltd
Alveolar Bone Loss
Dimensional Changes in Alveolar Ridge Preservation
Objective: The objective is to evaluate the dimensional changes of soft tissue and alveolar ridge after extraction of posterior elements with different clinical protocols of alveolar preservation.
- Trial name
- NCT06081296
- Testing
- Control group, Mixed free gingival graft group, Bone+ mixed free gingival graft group
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Renato Casarin
Alveolar Bone Loss, Periodontal Diseases
Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone Formation
Tooth extraction triggers a cascade of biological events mediated by the local inflammatory response following surgical intervention and by the loss of masticatory stimulation to the periodontium.
- Conditions
- Alveolar Bone Loss, Periodontal Diseases, Periodontal Bone Loss, Periodontal Atrophy
- Trial name
- NCT07573761
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Osteoarthritis of Multiple Joints
Probiotic for Pain Osteoarthritis
Many people with symptomatic Osteoarthritis (OA) report chronic joint pain, especially if those patients are older than 50 years.
- Trial name
- NCT03968770
- Testing
- Experimental group, Control group, Usual medical care
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Bruxism, Posture
Determining the Relationship Between Posture, Muscle Stiffness, Pain, and Jaw Functionality in Individuals With Bruxism
Bruxism is a repetitive jaw-muscle activity characterized by teeth clenching and/or grinding, often associated with temporomandibular joint dysfunction, pain, and impaired jaw function.
- Conditions
- Bruxism, Posture, Sleep Quality, Pain Assessment
- Trial name
- Bruxism (NCT07560670)
- Testing
- Bruxism Assessment Form, Clinical Examination, Patient Evaluation Form
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Arthritis, Spondylitis, Ankylosing
Natural History and Development of Spondyloarthritis
Background: Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine.
- Trial name
- NCT01422694
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Sjögren's Syndrome, Meibomian Gland Dysfunction
Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ?
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03060005
- Testing
- Tears Naturale Forte, liposic
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tung Wah Hospital
Arthritis
Effects of Cox-II Inhibitor on Biochemical Markers in Cardiovascular-related Adverse Effects
The selective cyclooxygenase-2 (COX-2) inhibitors have been associated with increased cardiovascular risk. The goal of the present study is to investigate the impacts of COX-2 inhibitors on biochemical indices in cardiovascular…
- Trial name
- NCT00944866
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Chung Hsing University
Acromegaly
A Phase 1 Clinical Trial of NTQ6179 Tablets in Healthy Volunteers
This is a phase 1, randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) of single oral doses of NTQ6179 tablets in healthy…
- Trial name
- NCT07909837
- Testing
- NTQ6179
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Nanjing Chia-tai Tianqing Pharmaceutical
MELAS Syndrome
L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
MELAS patients suffer from exercise intolerance, weakness, poor vision or blindness, poor growth, developmental delay, and deafness.
- Trial name
- NCT01603446
- Testing
- L-Arginine
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
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