Clinical trials: Myelomeningocele
Neurogenic Detrusor Overactivity
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
- Trial name
- KANGUROO (NCT05491525)
- Testing
- Vibegron
- Where
- 38 sites in United States, Belgium and 14 more
- Volunteers
- 71 people
- Sponsor
- Urovant Sciences GmbH
Paraplegia, Spinal, Myelomeningocele
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions
The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal…
- Trial name
- NCT01208584
- Testing
- fMRI, DTI
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Spina Bifida, Myelomeningocele
tSCS in Children With Spina Bifida
A single-center, open-label, investigational pilot trial to explore potential effects of transcutaneous spinal cord stimulation on leg muscle strength and walking in children with myelomeningocele.
- Trial name
- NCT07615686
- Testing
- Transcutaneous stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bailey Petersen
Spina Bifida, Myelomeningocele
Incontinence and Quality of Life in Children With Spina Bifida
This study aims to develop an innovative, interactive tool for joint use by spina bifida patients and their urologists to identify patients interested in addressing their urinary and fecal incontinence and establish continence…
- Trial name
- NCT03410667
- Testing
- Phase One: Exploration, Phase Two: Creation, Phase Three: Reflection
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Indiana University
Myelomeningocele, Brain Malformation
The Role of CSF in Chiari II Brain Malformation
Spina bifida, particularly its most severe form known as open spina bifida (myelomeningocele), is a significant congenital disorder that results in profound neurological impairments, including Chiari II malformation.
- Conditions
- Myelomeningocele, Brain Malformation, Chiari Malformation Type 2
- Trial name
- NCT06560788
- Testing
- collection of cerebrospinal fluid
- Volunteers
- 18 people
- Sponsor
- University College, London
Myelomeningocele
Open Spina Bifida Fetoscopic Repair Project
The aim of the study is to assess a new fetal surgery approach to repair open spina bifida. The fetal group hypothesis is to perform a minimally invasive procedure using a fetoscopic technique in order to access to amniotic…
- Trial name
- NCT03562286
- Testing
- Fetoscopy
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Medicina Perinatal Alta Especialidad, México
Myelomeningocele
Prenatal Endoscopic Repair of Fetal Spina Bifida
The purpose of this study is to determine the feasibility of prenatal minimally-invasive fetoscopic closure with i) uterine exteriorization for a minimally-invasive repair under amniotic carbon dioxide insufflation ii) two…
- Trial name
- ENDOSPIN (NCT02390895)
- Testing
- endoscopic repair of myelomeningocele before 26 SA
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Physical Therapy Modalities
Effects of Physical Therapy Associated With Photobiomodulation on Myelomeningocele
Myelomeningocele is a severe type of spina bifida, resulting from improper closure of the neural tube. This condition drastically affects the structures of the spinal cord, as a result the spinal cord, nerve roots and meninges…
- Trial name
- NCT04425330
- Testing
- physiotherapy exercises, PBM
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Spina Bifida; Fetus, Myelomeningocele
Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair
The objective is to test the efficacy of a laparotomy-assisted fetoscopic surgical approach to cover spina bifida spinal cord developmental defects using cryopreserved human umbilical cords (NEOX Cord 1K®) as a meningeal and skin…
- Conditions
- Spina Bifida; Fetus, Myelomeningocele, Myeloschisis
- Trial name
- HUC-FICS (NCT06042140)
- Testing
- NEOX Cord 1K applied fetoscopically
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Myelomeningocele
Role of Perforator Flaps in Back Defects Reconstruction
evaluation of perforator flaps versus perforator plus flaps
- Trial name
- NCT06405698
- Testing
- surgical closure of myelomeningocele defects by perforator flaps, surgical closure of myelomeningocele defects by perforator-plus flaps
- Volunteers
- 30 people
- Sponsor
- Assiut University
Myelomeningocele
Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial
Spina bifida, or myelomeningocele (MMC), is a birth defect that results in paralysis, excess fluid on the brain (hydrocephalus), and impaired ability to urinate and have bowel movements normally.
- Trial name
- CuRe (NCT04652908)
- Testing
- Placental Mesenchymal Stem Cells seeded on a commercially available dural graft extracellular matrix, Untreated contemporaneous cohort
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis
Cerebral Palsy, Stroke
Reliability of the Melbourne Assessment
The aim of the study is to investigate the reliability of the Melbourne Assessment.
- Conditions
- Cerebral Palsy, Stroke, Traumatic Brain Injury, Meningomyelocele
- Trial name
- NCT02595411
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital, Zurich
Neural Tube Defects
Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study
The purpose of the study is to compare the maternal, fetal and neonatal outcomes of a cohort of 60 patients in whom a multilayer closure with a Durepair patch is performed with a prior cohort of patients in whom a standardized…
- Trial name
- NCT03794011
- Testing
- fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baylor College of Medicine
Cerebral Palsy, Stroke
Feasibility of the Portable YouGrabber System
The aim of the study is to determine the feasibility of the portable version of the YouGrabber® system in children with central motor disorders.
- Conditions
- Cerebral Palsy, Stroke, Traumatic Brain Injury, Meningomyelocele
- Trial name
- YouGrabber (NCT02368223)
- Testing
- YouGrabber
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Children's Hospital, Zurich
Urologic Diseases
Outcomes of Proactive Management of Children With Myelomeningocele
Spina bifida birth prevalence in Africa is 0.13%. Myelomeningocele (MMC) represents the most frequent and most severe cause of NB in children. Treatment of neuropathic bladder secondary to spina bifida is an ongoing challenge.
- Trial name
- NCT06301802
- Testing
- CIC, Anticholinergic
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myelomeningocele Without Hydrocephalus, Sensory Defect
Effects of Photobiomodulation on Superficial Sensitivity and Muscle Activity of Individuals With Myelomeningocele
Myelomeningocele is a neural tube defect that occurs between the third and fourth week of gestation. Functional impairment occurs due to dysplasia of the nerve roots, which can lead to flaccid paralysis and sensory-motor…
- Conditions
- Myelomeningocele Without Hydrocephalus, Sensory Defect, Motor Activity
- Trial name
- NCT04035863
- Testing
- Low level laser therapy
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Meningomyelocele, Spinal Dysraphism
Management of Myelomeningocele Study (MOMS)
Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the underdeveloped area of the spinal cord is…
- Trial name
- MOMS (NCT00060606)
- Testing
- Prenatal Myelomeningocele Repair Surgery, Postnatal Myelomeningocele Repair Surgery
- Where
- 3 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Neurogenic Detrusor Overactivity
A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 2-15 years, with neurogenic detrusor overactivity.
- Trial name
- NCT00712322
- Testing
- Darifenacin
- Where
- 12 sites in United States, Colombia
- Volunteers
- 35 people
- Sponsor
- Warner Chilcott
Neurogenic Bladder, Myelomeningocele
Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Patients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure. Aim: To evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative…
- Trial name
- NCT03550898
- Testing
- Dynamic Ultrasonography
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre