Clinical trials: Myocardial Fractional Flow Reserve
Fractional Flow Reserve, Myocardial, Coronary Artery Disease
Performance of a New REsting Pressure Index During Invasive Angiography Compared To Adenosine Hyperemic FFR
To test the feasibility and diagnostic accuracy of a new automated pressure derived resting index (Pd/Pamin), using FFR as gold standard, in de novo coronary lesions in which invasive physiological evaluation is warranted.
- Trial name
- PREDICT (NCT03237169)
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 100 people
- Sponsor
- Centro Hospitalar Lisboa Ocidental
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction
IVUS Versus FFR for Non-infarct Related Artery Lesions in Patients With Multivessel Disease and Acute MI
The aim of the study is to compare clinical outcomes between intravascular ultrasound (IVUS)-guided treatment decision versus fractional flow reserve (FFR)-guided treatment decision for non-infarct related artery stenosis in…
- Trial name
- FRAME-AMI2 (NCT05812963)
- Testing
- IVUS-guided PCI group, FFR-guided PCI group
- Where
- 2 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Samsung Medical Center
Coronary Atherosclerosis, Coronary Artery Disease
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
In a prospective international multicenter observational study, 1080 stable chest pain patients (REALITY Advanced registry of CCTA patients) with the suspected chronic coronary syndrome will be enrolled.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Disease, Contrast-induced Nephropathy, Cerebrovascular Disease
- Trial name
- REALITY (NCT02440646)
- Testing
- Coronary computed tomography angiography, Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 4 sites in Estonia, Netherlands and 1 more
- Volunteers
- 1,080 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
Coronary Artery Disease
Impact of Interventional Revascularization on the Physiological Assessment of Bystander Coronary Lesions by FFR
The ABC-FFR trial examines the understudied hemodynamic interaction between parallel coronary stenoses, as the physiological impact of treating one lesion on the pressure indices of lesions in separate parallel branches is not…
- Trial name
- ABC-FFR (NCT07314879)
- Testing
- Hemodynamic Evaluation of Remote Lesion before & after PCI of Index Lesion
- Where
- 3 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Stable Ischemic Heart Disease, Coronary Artery Disease
Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive Cardiolens FFR-CT Pro Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities.
A multicentre, post-marketing, observational trial in 450 patients, whose standard diagnostic workup for chronic coronary syndromes provided for Invasive Coronary Angiography (ICA).
- Trial name
- NCT04777513
- Testing
- CCTA (Coronary Computed Tomography Angiography), ICA (Invasive Coronary Angiography), FFR (Fractional Flow Reserve)
- Where
- 11 sites in Poland
- Volunteers
- 450 people
- Sponsor
- Hemolens Diagnostics Sp. z o.o.
Coronary Artery Disease
Clinical Outcomes of Patients With Deferred Revascularization Based on FFR and iFR Negative Coronary Artery Lesions.
The objective is to assess long-term clinical outcomes of patients in whom intervention of coronary lesions was deferred due to negative fractional flow reserve (FFR) and negative Instantaneous wave-free ratio (iFR) in a…
- Trial name
- NCT05240768
- Testing
- Fractional flow reserve, instantaneous wave-free Ratio
- Where
- Pakistan
- Volunteers
- 345 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Coronary Artery Disease
Physio PCI: Impact of Coronary Angioplasty on Non-hyperaemic Pressure Ratio in Patients With Coronary Artery Disease
The use of intra coronary physiological assessment with fractional flow reserve (FFR) is nowadays the standard approach to define ischemia-inducing stenosis and guide myocardial revascularization strategy in patients with…
- Trial name
- NCT04679805
- Where
- United Arab Emirates
- Volunteers
- 3 people
- Sponsor
- Ceric Sàrl
Coronary Artery Disease, Acute Coronary Syndromes (ACS)
DECisive Intracoronary PHysiology and Imaging in the Evaluation and Reclassification of Non-culprit Lesions in Acute Coronary Syndrome
Despite all advances in diagnostic and therapeutic methods over the past century, ischemic heart disease (IHD) remains a leading cause of mortality and morbidity worldwide.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes (ACS), Optic Coherence Tomography, Fractional Flow Reserve
- Trial name
- DECIPHER (NCT07548554)
- Testing
- Intracoronary Physiology, Intracoronary imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Artery Disease (CAD)
Evaluation of XTR004 as a Novel 18F-labeled PET MPI Tracer in Diagnosis of Known or Suspected CAD
The diagnostic efficacy and safety of the XTR004 myocardial perfusion PET imaging tracer are evaluated for known or suspected CAD with the use of invasive coronary angiography as the reference standard for the diagnosis of CAD…
- Trial name
- NCT05885841
- Testing
- XTR004
- Where
- 2 sites in China
- Volunteers
- 83 people
- Sponsor
- Sinotau Pharmaceutical Group
Coronary Artery Disease
Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia
The purpose of this study is to determine if regadenoson is as safe and effective as adenosine when used in the cardiac catheterization lab during measurement of coronary flow reserve and fractional flow reserve.
- Trial name
- NCT01161121
- Testing
- adenosine, regadenoson
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- St. Louis University
Coronary Artery Disease (CAD), Computed Tomography Angiography
AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)
The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated…
- Conditions
- Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence)
- Trial name
- ACTION (NCT07577609)
- Where
- Ireland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Galway
Coronary Stenosis
FrActional Flow Reserve Guided Drug Coated Balloon Only Strategy in De Novo coronarY Lesions (FADDY)
Drug-eluting stent (DES) has been the primary choice for in suit coronary lesions treatment. In comparison to bare-metal stent (BMS), it evidently decreases the rate of restenosis.
- Trial name
- FADDY (NCT03452904)
- Testing
- Drug-coated balloon, Drug-eluting stent
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Coronary Disease
Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization Trial
The FARGO trial is a prospective, randomized (1:1), multicenter study. The aim of the study is to assess the importance of fractional flow reserve (FFR) assessment prior to coronary artery bypass grafting (CABG) with respect to…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arteriosclerosis
- Trial name
- FARGO (NCT02477371)
- Testing
- Fractional flow reserve-guided CABG, Angiography-guided CABG
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Fractional Flow Reserve, Myocardial
Safety of Negative FrActional Flow Reserve in Patients With ChallEnging Lesions
Fractional Flow Reserve (FFR) has recently emerged and has been largely validated as a safe and efficacious way of ischemia testing for patients with stable angina.
- Trial name
- FACE (NCT02590926)
- Testing
- Fractional Flow Reserve, Myocardial
- Where
- Italy
- Volunteers
- 285 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Coronary Artery Disease
Computed Tomography-derived Fractional Flow Reserve vs. Angiographic Quantitative Flow Ratio in Management of Patients With Coronary Artery Disease
This is a multi-center, randomized controlled trial to compare the clinical outcomes between CT-derived fractional flow reserve (CT-FFR) guided strategy and angiography-derived quantitative flow ratio (QFR) guided strategy among…
- Trial name
- CONQUER (NCT07308496)
- Testing
- CT-FFR guided strategy, QFR guided strategy
- Volunteers
- 1,402 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stable Angina
Fractional FLow Reserve And IVUS for Clinical OUtcomes in Patients With InteRmediate Stenosis
To compare the safety and efficacy of FFR (fractional flow reserve)-guided percutaneous coronary intervention (PCI) strategy with IVUS (intravascular ultrasound [IVUS])-guided PCI in patients with intermediate coronary stenosis.
- Trial name
- FLAVOUR (NCT02673424)
- Testing
- FFR-guided stenting, IVUS-guided stenting
- Where
- 5 sites in China, South Korea
- Volunteers
- 1,700 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Role of On-site CT-derived FFR in the Management of Suspect CAD Patients
The primary of this registry is to evaluate whether the availability of CTA/CT-FFR procedure could effectively optimize the flow of clinical practice of stable chest pain versus conventional clinical pathway in decision making…
- Trial name
- TARGET (NCT03901326)
- Testing
- CT-FFR assessment
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain
To determine whether, in a population of patients presenting to the rapid access chest pain clinic (RACPC), routine FFRct (Fractional Flow Reserve Computed Tomography) as a default test is superior in terms of resource…
- Trial name
- FORECAST (NCT03187639)
- Testing
- FFRct, Standard care
- Where
- United Kingdom
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Coronary Artery Disease, Valvular Heart Disease
Strategies for Revascularization in Patients Undergoing Heart Valve Surgery With Concomitant Coronary Artery Disease
The purpose of this study is to determine whether, in patients undergoing elective valvular heart surgery, revascularization of concomitant coronary artery disease (CAD) guided by FFR (Fractional flow reserve) would be superior…
- Trial name
- SAVE-IT (NCT02173860)
- Testing
- FFR-guided surgical revascularization, Angio-guided surgical revascularization
- Where
- Portugal
- Volunteers
- 502 people
- Sponsor
- Portuguese Society of Cardiology
Chest Pain, Stable Angina
In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?
A randomised controlled trial to compare two strategies for the investigation of coronary artery disease at the time of angiography.
- Conditions
- Chest Pain, Stable Angina, Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
- Trial name
- RIPCORD 2 (NCT02892903)
- Testing
- Routine Measurement of FFR
- Where
- 17 sites in United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust