Clinical trials: Myocardial Function
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Pregnancy
Echo-Cardiographic Assessment of Cardiovascular Characteristics During Pregnancy and Postpartum Periods
The purpose of this echocardiographic study is to restudy the longitudinal changes in cardiac size and function during and after pregnancy in healthy women using relatively new parameters of systolic and diastolic function as…
- Trial name
- NCT00522977
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Coronary Artery Disease
Fear of Activity and Functional Capacity in Patients With Coronary Artery Disease
To identify whether coronary artery disease (CAD) patients have fear of activity, and to assess the relationship between fear of activity and exercise capacity in CAD patients.
- Trial name
- NCT04335760
- Testing
- Modified Bruce protocol on treadmill
- Where
- Turkey (Türkiye)
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Tuğba Atan
Liver Dysfunction, Liver Insufficiency
An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Function
This is an investigational study of experimental Medication BMS-986231 given to participants with weakened or damaged liver function.
- Conditions
- Liver Dysfunction, Liver Insufficiency, Hepatic Failure, Myocardial Failure
- Trial name
- NCT03515980
- Testing
- BMS-986231
- Where
- 4 sites in Hungary, Poland
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Disease
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
- Trial name
- NCT00745693
- Testing
- Endothelin-1, BQ-123 and BQ-788
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Myocardial Endothelial Function
Effect of a Single Ultra-Processed Meal on Myocardial Endothelial Function Assessed With Positron Emission Tomography
The objective of this study is to evaluate the effect of an ultra-processed meal on myocardial endothelial function using positron emission tomography (PET).
- Trial name
- SUPPER (NCT06353009)
- Testing
- NOVA4 meal, NOVA1-3 meal
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Matthieu Pelletier-Galarneau, MD MSc
This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging.
Propofol Induction's Effect on Cardiac Function
Background: Propofol effects dose-dependent myocardial depression, but there is little clinical data available regarding the direct impact of propofol induction on myocardial function.
- Conditions
- This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging., This is the First Study, to Our Knowledge, Which Has Evaluated the Possible Impact of Propofol Induction on LV Function.
- Trial name
- NCT02408341
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Type 2 Diabetes
The Impact of Free Fatty Acid (FFA-) Suppression on Myocardial Lipids and Function in Patients With Type 2 Diabetes
There is evidence that inhibition of FFA-release by acipimox is associated with a significant decrease in myocardial lipid content (MYCL) as well as the ejection fraction (as a marker of systolic left ventricular function) in…
- Trial name
- HYPOTESIS (NCT01980524)
- Testing
- acipimox
- Where
- Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiac Structure and Function, Intracardiac Hemodynamic
Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders
The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions.
- Trial name
- IHMS (NCT06075342)
- Testing
- exercise
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Acute Coronary Syndrome, Myocardial Infarction (MI)
Clinical Echocardiography and S' Wave for Early Recognition of Acute Coronary Syndrome in the Emergency Department, A Prospective Study
The goal of this prospective observational study is to assess the diagnostic accuracy of the tissue Doppler imaging (TDI) S' wave in detecting acute coronary syndrome (ACS) in adult patients presenting to the emergency department…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction (MI), Non-ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- CLEAR_ECHO (NCT06860997)
- Testing
- Tissue Doppler Imaging (TDI) S' Wave Echocardiography
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Athlete Heart
Myocardial Mechanics in Athlete's Heart
Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling.
- Trial name
- NCT05543525
- Testing
- Echocardiography, Cardiopulmonary exercise testing
- Where
- France
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Thyroid, Thyroidectomy
Post Thyroidectomy Myocardial Function
Protocol Synopsis Protocol title: Post thyroidectomy myocardial function Purpose: Evaluation of the effects of total thyroidectomy on myocardial function Design: Prospective, single-center, cohort study Patient Population: Male…
- Conditions
- Thyroid, Thyroidectomy, Myocardial Function
- Trial name
- TECH (NCT03060499)
- Where
- Greece
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Fabry Disease
Study of the Relation Between Lipid Myocardial Overload Evaluated by Cardiac Magnetic Resonance Imaging (MRI), Alteration of Longitudinal Myocardial Deformations by Echocardiography, and Clinical Achievements (Functional, Biological and Electrical) in Fabry Disease, and Its Outcomes.
Anderson-Fabry disease is a genetic lysosomal storage disease, linked to chromosome X (gene GLA), responsible of enzyme synthesis deficit in α-galactosidase A with intracellular sphingolipids accumulation and multiorganic…
- Trial name
- FABRY-Image (NCT03123523)
- Testing
- Echocardiography at T0, Exercise test, Biological assays
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Cardiomyopathy, Hypertrophic, Coronary Disease
Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers
Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart…
- Conditions
- Cardiomyopathy, Hypertrophic, Coronary Disease, Healthy, Myocardial Ischemia
- Trial name
- NCT00001459
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Stroke, Ischemic
Ischemic Conditioning Improves Walking Function Post Stroke
This innovative study will address scientific and clinical areas relatively unexplored in chronic stroke that could lead to greater recovery of walking.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Cardiovascular
- Trial name
- NCT04038697
- Testing
- Ischemic Conditioning, Treadmill Training
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Ischaemic Heart Diseases
The Effect of Ischaemic-reperfusion on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789451
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiac Rehabilitation, Acute Coronary Syndrome
The Influence of Cardiac Rehabilitation on the Health State After ACS
Coronary heart disease, including acute coronary syndromes (ACS), is the leading cause of death in European countries. One of the basic elements of secondary and tertiary prevention of ACS is cardiac rehabilitation.
- Trial name
- CARDIO-REH (NCT03935438)
- Testing
- Cardiac rehabilitation
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Atrial Function
Normal Values for Myocardial Left Atrial Strain
Transversal retrospective and unicentric study. The investigators sought to determine the normal values for two-dimensional myocardial left atrial strain for the cardiology ultrasound system available in their centre (Philips…
- Trial name
- NCT03874624
- Testing
- two-dimensional speckle tracking
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau