Clinical trials: Myocardial Function
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Vascular Function, Atherothrombosis
Effect of Fire Suppression and Emergency Duties on Vascular Function
Firefighters are at increased risk of death from heart attacks when compared to other emergencyy service professionals whose jobs involve similar components such as emergency call-outs and shift work.
- Trial name
- NCT01805063
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Type 1 Diabetes Mellitus, Coronary Artery Disease
Isometric Handgrip Exercise -MRI in Children and Adolescents
This project aims to assess coronary vessel response to isometric handgrip exercise (IHE) during magnetic resonance imaging (MRI) in children with T1D children and healthy controls.
- Trial name
- NCT03506711
- Testing
- Isometric Handgrip Exercise during magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Angina, Coronary Artery Disease
Exercise-training Before Coronary Artery Bypass Graft (CABG)
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small…
- Trial name
- NCT00218985
- Testing
- Exercise training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Aortic Regurgitation
Diastolic Dysfunction in Aortic Regurgitation
Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.
- Trial name
- NCT00976625
- Testing
- Aortic Valve Replacement
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bern
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Myocardial Injury, Atherosclerosis Cardiovascular Disease
Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)
Coronary artery disease is one of the most common causes of illness and death. It develops when fatty deposits, known as plaques, build up in the arteries that supply blood to the heart.
- Conditions
- Myocardial Injury, Atherosclerosis Cardiovascular Disease, Cardiac Imaging Techniques, Genetics
- Trial name
- OXAMI (NCT07772570)
- Testing
- blood sampling, Intracoronary Imaging, Cardiovascular Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Coronary Artery Occlusion
Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery
The purpose of this study is to study the effects of N-acetylcysteine on pulmonary function in high-risk patients undergoing off-pump coronary bypass surgery.
- Trial name
- NCT01021163
- Testing
- N-acetylcysteine, saline
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Coronary Artery Disease, Endothelial Function
The Association of Platelet Function and Endothelial Function of the Brachial Artery
The proposed study is a prospective one, and will be held on consecutive individuals undergoing the non-invasive brachial artery flow-mediated dilation (FMD) ultrasound for endothelial function at the endothelial function…
- Conditions
- Coronary Artery Disease, Endothelial Function, Thrombosis
- Trial name
- NCT00363818
- Where
- 2 sites in Israel
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Gender Dysphoria, Hormone Therapy Induced Morphologic Change
Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content
Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body.
- Trial name
- NCT06291675
- Testing
- gender-affirming hormone therapy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Heart Failure, Systolic, Ketonemia
Ketones in Heart Failure - Effects on Cardiac Efficiency
Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized…
- Trial name
- NCT03073356
- Testing
- Infusion of 3-OHB
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Myocardial Fibrosis, Function and Aging
In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age.
- Trial name
- MARVEL (NCT03064503)
- Testing
- Blood sampling, MRI, Skin auto-fluorescence
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Gender Dysphoria
Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat Content
Background: Sex hormones are believed to play an important role in the development and progression of cardiovascular disease. However, the gender gap in onset and mortality is not yet completely understood.
- Trial name
- NCT06245681
- Testing
- gender affirming hormone therapy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Psoriasis
Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis
Psoriasis has been associated with an increasing risk for atherosclerosis. The investigators investigated whether surrogate markers of subclinical atherosclerosis, vascular dysfunction and myocardial dysfunction are impaired in…
- Trial name
- NCT02144857
- Testing
- etanercept, ustekinumab, cyclosporine
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Athens
Acute Coronary Syndome
Is Efficacy of PLAtelet Aggregation Inhibition by Ticagrelor Mediated P2Y12 Blockade Dependent Upon Endogenous Endothelial Nitric OXide?
Background Acute coronary syndrome (ACS) is a term representing all diseases related to reduction in blood flow to the heart characterised by clot formation over a segment of blood vessel narrowing.
- Trial name
- PLATE NOX (NCT02169596)
- Testing
- Ticagrelor, EndoPAT - endothelial assessment
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Coronary Artery Disease
Biomarkers for Cardiovascular Disease
Biomarkers for Cardiovascular Disease Summary: This study will examine the function of the lining cells of blood vessels and measure substances in the blood to see how they relate to various blood tests, including new tests under…
- Trial name
- NCT00109018
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
The collection of human specimens from both patients and healthy volunteers is necessary for the development of laboratory assays to further basic and clinical research studies.
- Trial name
- NCT00047996
- Where
- 2 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789243
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabetes-related Complications
Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes
Summary. Theoretical Rationale: The left ventricular myocardial performance results from a complex interplay between linear deformations (longitudinal, circumferential and radial) and twist/ untwist mechanics.
- Trial name
- NCT02505451
- Testing
- dobutamine
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Atherosclerosis, Diabetes
Quantitative Assessment and Characterization of Microvascular Function Using Diffuse Optical Tomography
Atherosclerosis is accompanied by microvascular dysfunction (an impairment of blood vessels to dilate or constrict in response to demand).
- Conditions
- Atherosclerosis, Diabetes, Coronary Artery Disease
- Trial name
- DOT (NCT03411213)
- Testing
- diffuse optical tomography
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust