Clinical trials: Myocardial Function
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Coronary Artery Disease, Postprandial Hyperglycemia
Vitamin D Supplementation in CAD and Postchallenge Hyperglycemia
The main aim of the investigation is to clarify, whether vitamin D supplementation in coronary artery disease patients with vitamin D deficiency and postchallenge hyperglycemia has an impact on endothelial dysfunction and…
- Conditions
- Coronary Artery Disease, Postprandial Hyperglycemia, Vitamin D Deficiency
- Trial name
- NCT01183442
- Testing
- vitamin D
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Graz
Coronary Artery Disease
Symptom Management Intervention in Elderly Coronary Artery Bypass Patients
The major purpose of this experimental study is to test the effects of the symptom management home care nursing intervention (SMHCNI) on recovery outcomes of elderly CABG patients, using a randomized, two group (n=284) repeated…
- Trial name
- NCT00572988
- Volunteers
- 232 people
- Sponsor
- University of Nebraska
Coronary Heart Disease
Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective…
- Trial name
- GlikoOxEND (NCT07451873)
- Where
- Croatia
- Volunteers
- 35 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Arteriosclerosis, Acute Coronary Syndrome
GRAVITAS: Gauging Responsiveness With A VerifyNow Assay-Impact On Thrombosis And Safety
The objective of the GRAVITAS trial is to determine whether tailored anti-platelet therapy using the Accumetrics VerifyNow P2Y12 assay reduces major adverse cardiovascular events after drug-eluting stent implantation.
- Trial name
- GRAVITAS (NCT00645918)
- Testing
- clopidogrel
- Where
- 82 sites in United States, Canada
- Volunteers
- 2,800 people
- Sponsor
- Accumetrics, Inc.
Heart Failure
The Role of Nuclear Imaging in Heart Failure
Heart failure is a clinical syndrome of exercise intolerance and/or congestion. The potential roles of myocardial perfusion and metabolic abnormalities in subjects with cardiovascular risks, metabolic disease and heart failure…
- Trial name
- NCT02697669
- Testing
- 18F-FDG PET
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Far Eastern Memorial Hospital
Functional Mitral Regurgitation
Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Fibrosis (DEFORM)
The goal of this clinical trial is to learn about the effect of dapagliflozin on reducing the degree of mitral regurgitation and myocardial fibrosis in patients with functional mitral regurgitation (FMR) of more than moderate and…
- Trial name
- DEFORM (NCT05848102)
- Testing
- dapagliflozin
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- Sun Yat-sen University
Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting.
This randomized, double-blind clinical trial aims to evaluate the impact of photobiomodulation therapy on postoperative outcomes in patients undergoing coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Graft (CABG), Surgical Wound Healing
- Trial name
- PHOTON (NCT07699679)
- Testing
- Photobiomodulation Therapy, Conventional Saphenous Vein Harvesting, No-Touch Saphenous Vein Harvesting
- Where
- Brazil
- Volunteers
- 292 people
- Sponsor
- Federal University of São Paulo
Systolic Dysfunction
Association of PICP Serum Marker in Patients With LVSD
The purpose of this study is to determine if the carboxy-terminal of procollagen type I (PICP) can be a useful marker of different degrees of myocardial fibrosis.
- Trial name
- NCT00232388
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Myocardial Viability
- Trial name
- NCT06047028
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Human Immunodeficiency Virus, Coronary Artery Disease
Effect of Evolocumab on Coronary Endothelial Function
The investigators propose a pilot study using (1) MRI to assess coronary artery endothelial function, (2) brachial ultrasound to assess systemic endothelial function, (3) serum markers of inflammation and of endothelial cell…
- Trial name
- EVOLVE (NCT03500302)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Coronary Disease
Renal Function in Patients Submitted to Myocardial Revascularization Surgery
Acute renal insufficiency (ARI) represents a frequent and serious complication in patients submitted to cardiac surgery, and is associated with increases in time of hospitalization, costs, morbidity and mortality.
- Trial name
- NCT00905775
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Unstable Angina, NSTEMI
Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition
The purpose of this study is to evaluate the efficacy (reduction of major ischemic events at 6 and 12 months of follow-up) of a tailored clopidogrel therapy in patients with UA/NSTEMI undergoing PCI with stent implantation and…
- Trial name
- DANTE (NCT00774475)
- Testing
- comparison of different dosage of clopidogrel, doubled therapy
- Where
- Italy
- Volunteers
- 442 people
- Sponsor
- University of Florence
Acute Coronary Syndrome
Continuous Clopidogrel Dose Adjustment in Acute Coronary Syndrome Patients With High On-treatment Platelet Reactivity
The purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with…
- Trial name
- NCT02096419
- Testing
- Clopidogrel dose adjustment
- Where
- Croatia
- Volunteers
- 87 people
- Sponsor
- University of Zagreb
Chronic Total Occlusion of Coronary Artery
Revascularization Versus Optimal Medical Therapy of Chronic Total Coronary Occlusions on Left Ventricular Ischemia Reduction
Rationale: Randomized trials could not yet establish favourable outcomes of CTO PCI on hard endpoints such as ejection fraction or mortality, when compared to optimal medical therapy.
- Trial name
- REVISE-CTO (NCT03756870)
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Vasospastic Angina
The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina Pectoris
Vasospastic angina is increasingly recognized as an important contributor to anginal symptoms in patients with non-obstructive coronary artery disease (ANOCA).
- Trial name
- ViVA (NCT06415227)
- Testing
- Vericiguat
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Endothelial Dysfunction, Apical Ballooning Syndrome
The Relationship Between the Response to Mental Stress and Vascular Endothelial Function
The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects.
- Conditions
- Coronary Endothelial Dysfunction, Apical Ballooning Syndrome, Myocardial Infarction
- Trial name
- NCT00975559
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Myocardial Infarction, Heart Failure
Sodium Thiosulfate to Preserve Cardiac Function in STEMI
Rationale: Timely and effective reperfusion by primary percutaneous coronary intervention (PPCI) is currently the most effective treatment of ST-segment elevation myocardial infarction (STEMI).
- Trial name
- GIPS-IV (NCT02899364)
- Testing
- Sodium thiosulfate, Sodium chloride 0.9%, primary percutaneous coronary intervention
- Where
- 3 sites in Netherlands
- Volunteers
- 380 people
- Sponsor
- University Medical Center Groningen