Clinical trials: Myocardial Function
ST Elevation Acute Myocardial Infarction
Myocardial Function Recovery Prediction Post Primary PCI Using the Estimate of Myocardial Salvage in Gated SPECT Early After Acute Myocardial Infarction
Our aim was to correlate functional and perfusion abnormalities early post primary percutaneous coronary intervention after acute myocardial infarction in ST elevation myocardial infarction patients to estimate myocardial…
- Trial name
- NCT07568587
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Fayoum University
Acute Myocardial Infarction
Effects of Tai Chi Chuan in Patients After Recent Acute Myocardial Infarction
This is a randomized Clinical Trial to assess the effects of Tai Chi Chuan on blood pressure, respiratory muscle strength and functional capacity in patients after recent acute myocardial infarction.
- Trial name
- NCT01340716
- Testing
- Tai Chi Chuan exercise, stretching exercise
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Coronary Artery Disease, Oxidative Stress
Effects of Curcumin on Markers of Cardiovascular Risk in Patients With CAD
General Objective To evaluate the effects of curcumin supplementation on cardiovascular risk markers, inflammation, oxidative stress and functional capacity in participants with coronary artery disease.
- Conditions
- Coronary Artery Disease, Oxidative Stress, Inflammation
- Trial name
- NCT04458116
- Testing
- Curcumin
- Where
- Brazil
- Sponsor
- Universidade Federal Fluminense
Coronary Atherosclerosis
Endothelial Function-guided Therapy Compared to Usual Care in Patients With NOCAD
The current study is designed to test the hypothesis that compared to conventional treatment; endothelial function-guided treatment reduces adverse cardiovascular events in patients with non-obstructive coronary artery disease…
- Trial name
- EndoGET (NCT02313987)
- Where
- 2 sites in Israel
- Sponsor
- Itamar-Medical, Israel
Cardiovascular Diseases, Smoking
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
The purpose of this study is to demonstrate improvement in flow mediated dilation (FMD), a functional endpoint associated with the progression of atherosclerosis, when switching from cigarettes to the Tobacco Heating System (THS)…
- Conditions
- Cardiovascular Diseases, Smoking, Tobacco Use, Peripheral Arterial Disease
- Trial name
- NCT05566678
- Testing
- Cigarette, THS, Smoking Abstinence
- Sponsor
- Philip Morris Products S.A.
Diabetes Type 2
Mineralocorticoid Receptor Antagonists in Type 2 Diabetes
The aim of this study is to investigate the effect of selective blocking of the mineralocorticoid receptor in patients with type 2 diabetes on insulin resistance, lipid metabolism and myocardial function.
- Trial name
- NCT02809963
- Testing
- Eplerenone
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Herlev Hospital
Coronary Artery Disease, Left Main Coronary Artery Stenosis
Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR
The assessment of Left Main Coronary Artery (LMCA) lesions by means of coronary angiography renders serious limitations. Studies with a limited number of patients have shown that a value of FFR (Fractional Flow Reserve) above…
- Conditions
- Coronary Artery Disease, Left Main Coronary Artery Stenosis, Left Main Coronary Artery Disease, Restenosis, Coronary
- Trial name
- iLITRO (NCT03767621)
- Testing
- Indication of revascularization
- Where
- 38 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Fundación EPIC
Coronary Artery Disease
The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells
The objectives of the study are to test the hypothesis that external counter pulsation therapy (ECPT) provides clinical benefit by improving the number and function of endothelial progenitor cells (EPCs) in peripheral blood of…
- Trial name
- NCT00272571
- Testing
- External counter pulsation therapy
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Rheumatoid Arthritis, Coronary Artery Disease
Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease
Inhibition of interleukin-1 (IL-1) activity in patients with RA without CAD ameliorates vascular and LV function. Moreover, data from species shows beneficial effect of this treatment on LV function after experimental myocardial…
- Conditions
- Rheumatoid Arthritis, Coronary Artery Disease, Inflammation
- Trial name
- NCT01566201
- Testing
- anakinra
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Athens
Stroke, Cardiovascular
Effects of Seated Tai Chi on Recovery Among Stroke Survivors
A randomized controlled trial using seated Tai Chi (TC) as a rehabilitation intervention will be conducted among subacute stroke survivors.
- Trial name
- NCT04138407
- Testing
- seated Tai Chi, Usual rehabilitation exercise
- Volunteers
- 320 people
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Diseases
Effect of Trimetazidine During the Primary PCI on Cardiac Function in Patients With ST-elevation Myocardial Infarction
Giving preoperative loading dose of 60mg of trimetazidine can safely and effectively reduce the PCI-related myocardial damage for the patients undergoing selective PCI.
- Trial name
- NCT02826616
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Heart Failure
Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD
Left ventricular assist devices (LVADs) are one treatment option for people with congestive heart failure. This study will evaluate the safety of injecting mesenchymal precursor cells (MPCs) into the heart during LVAD…
- Trial name
- NCT00927784
- Testing
- Mesenchymal Precursor cells (RevascorTM), Cryoprotective media alone
- Where
- 17 sites in United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myocardial Infarction, Coronary Microvascular Disease
A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)
The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).
- Trial name
- NCT05793567
- Testing
- Coronary angiogram with coronary reactivity testing (CRT)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Atherosclerosis
Cardiac Rehabilitation and Coronary Artery Disease
Patients with coronary artery disease (CAD) aged 40-70 years will undergo exercise training (thrice weekly for 12 weeks). A reference group composed of healthy individuals will be included.
- Trial name
- NCT06579807
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Chronic Kidney Diseases
Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?
This study aims at evaluating, in chronic kidney disease patients on dialysis, the effect of acute per- or pre-dialytic physical exercise on regional myocardial function and myocardial stunning, blood viscosity, arterial…
- Trial name
- EXP DIAL (NCT04831021)
- Testing
- Dialysis without physical exercise, Dialysis with pre-dialytic physical exercise, Dialysis with per-dialytic physical exercise
- Where
- 2 sites in France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Montpellier
Heart Failure, Reduced Ejection Fraction
Cardiometabolic Effects of Dapagliflozin in Heart Failure With Reduced or Mildly Reduced Ejection Fraction
Gliflozins have demonstrated a beneficial effect in terms of incident heart failure and related events in patients with or without diabetes.
- Trial name
- ICARD (NCT05420285)
- Testing
- Dapagliflozin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Aortic Regurgitation
Diastolic Dysfunction in Aortic Regurgitation
Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.
- Trial name
- NCT00976625
- Testing
- Aortic Valve Replacement
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bern
Acute Coronary Syndrome, Addiction
Addiction and Acute Coronary Syndrome
the study aims to 1. identify the effect of addiction on TIMI flow in patients presented with acute coronary syndrome. 2. identify the effect of addiction on outcomes of medical treatment of patients presenting with acute…
- Trial name
- NCT05605106
- Testing
- speckle tracking echocardiography, Percutaneous coronary intervention
- Volunteers
- 72 people
- Sponsor
- Assiut University
Coronary Artery Disease
A Prospective, Single-site, Single-group Value Study on the Diagnosis of Functional Myocardial Ischemia Based on IVUS Plaque Characteristics
This study aims to evaluate the accuracy of IVUS-calculated percent atheroma volume (PAV) for diagnosing functional myocardial ischemia, using FFR as the gold standard.
- Trial name
- NCT07176585
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Insight Lifetech Co., Ltd.