Clinical trials: Myocardial Function
Myocardial Ischemia, Exercise
Exercise-induced Changes in Cardiac Function & Morphology
Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity.
- Conditions
- Myocardial Ischemia, Exercise, Myocardial Contraction, Myocardial Stunning
- Trial name
- NCT01179802
- Testing
- Strenuous Endurance exercise
- Where
- Switzerland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation, Atrial Flutter
EARLY-MYO-AF Registry
The purpose of this registry is to depict the myocardial function improvement in AF patients by integrated therapy and to assess the prognostic discrepancies of various intervention modalities.
- Trial name
- NCT04512222
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- RenJi Hospital
Myocardial Infarction
The Effect of Granulocyte Colony Stimulating Factor (G-CSF) on Myocardial Function After Acute Anterior Myocardial Infarction, a Prospective Double Blind Randomized Placebo Controlled Study
The investigators applied G-CSF to patients 2 weeks after acute anterior MI and successful PCI to evaluate the efficacy and safety of G-CSF in improving myocardial function as cytokine which improve inflammation and mobilize stem…
- Trial name
- NCT00756756
- Testing
- G-CSF
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Shiraz University of Medical Sciences
Ischemic Cardiomyopathy
Comparison of Two Exercise Training Modes on Left Myocardial Regional Function After Myocardial Infarction Evaluated by 2D Strain Ultrasound
Ischemic cardiomyopathy, defined by a deficiency in oxygenation of the myocardium due to a narrowing of the coronary arteries, is a major problem for public health.
- Trial name
- STRAICT (NCT04190394)
- Testing
- Intermittent retraining program.
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Myocardial Infarction
The Effect of Exercise Training on Cardiac Structure and Function
Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease.
- Trial name
- NCT02224495
- Testing
- Structured exercise training
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Gaia Hospital
Syndrome X
APEX Study: Effects of Allopurinol on Coronary and Peripheral Endothelial Function in Patients With Cardiac Syndrome X
Morbidity of patients with cardiac syndrome X (typical anginal-like chest pain and normal coronary arteriograms) is high with continuing episodes of chest pain and frequent hospital readmissions.
- Trial name
- APEX (NCT00512057)
- Testing
- allopurinol
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Coronary Artery Disease
Resistance on Antithrombotic Drugs in Ischemic Heart Disease
The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary…
- Trial name
- NCT00742430
- Testing
- PCI
- Where
- Croatia
- Volunteers
- 141 people
- Sponsor
- University of Zagreb
Coronary Artery Disease
Evaluation of an Ayurvedic Herbal Compound Compared to Vitamins C+E and Placebo on Vascular Function in High-Risk Subjects
This was a randomized controlled trial aimed to evaluate the effects of an herbal Ayurvedic herbal supplement in comparison to a Vitamin C/E supplement and an inert placebo on heart health.
- Trial name
- NCT07206901
- Testing
- Maharishi Amrit Kalash, vitamin C + E
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Maharishi International University
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Myocardial Infarction
Physiologic Assessment of Thrombus Aspiration in Acute ST-segment Elevation Myocardial Infarction Patients
The Physiologic Assessment of Thrombus Aspiration in ST-segment Elevation Myocardial Infarction (PATA-STEMI) trial is a single center, prospective, randomized trial with a planned inclusion of 128 patients with the first…
- Trial name
- PATA-STEMI (NCT01824641)
- Testing
- Eliminate aspiration catheter, Conventional primary angioplasty
- Where
- 2 sites in Serbia
- Volunteers
- 128 people
- Sponsor
- Clinical Centre of Serbia
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Obesity
Effects of Exercise Intensity in Obese Children and Adolescents
The prevalence of paediatric obesity has increased over the last two decades and with it, an increased diagnosis of lifestyle-related diseases in children and adolescents.
- Trial name
- NCT01991106
- Testing
- High intensity interval training, Moderate intensity continuous training, Nutritional advice
- Where
- 2 sites in Australia, Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Myocardial Viability
- Trial name
- NCT06047028
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Coronary Artery Disease, Coronary Atheroscleroses
Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - IV
This study is a single-center, prospective cohort study. The study is designed to identify novel circulating biomarkers for early prediction of high-risk coronary plaques.
- Conditions
- Coronary Artery Disease, Coronary Atheroscleroses, Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
- Trial name
- RECOGNIZE-IV (NCT06793787)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Type 2 Diabetes Mellitus
Effect of Exenatide on Liver and Heart Fat and Inflammation
The purpose of this study is to examine the effect of exenatide on liver and heart (myocardial) fat and inflammation.
- Trial name
- NCT01951651
- Testing
- Exenatide, Glipizide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Mitral Valve Regurgitation, Left Ventricular Dysfunction
VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study
The purpose of this prospective, non-randomized, single-arm feasibility study is to evaluate safety and feasibility of the iCoapsys System in patients with functional mitral valve insufficiency caused by annular dilation and/or…
- Conditions
- Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure, Mitral Insufficiency
- Trial name
- VIVID (NCT00512005)
- Testing
- Percutaneous mitral valve repair
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Myocor
Angina (Stable), Coronary Artery Disease(CAD)
Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds
ORBITA-SOLAR is an invasive physiological cardiac catheterisation study that aims to determine whether different coronary stenoses have different angina thresholds.
- Conditions
- Angina (Stable), Coronary Artery Disease(CAD), Ischaemic Heart Disease (IHD)
- Trial name
- ORBITA-SOLAR (NCT07386418)
- Testing
- Percutaneous coronary intervention (PCI), Measurement of the angina threshold
- Where
- 7 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Acute Myocardial Infarction
Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate in STEMI Patients
Prasugrel and ticagrelor, new P2Y12-ADP receptor antagonists, are associated with greater pharmacodynamic inhibition and reduction of cardiovascular events in patients with an acute coronary syndrome.
- Trial name
- ECCLIPSE-STEMI (NCT02929888)
- Testing
- Lysine Acetilsalicilate, Aspirin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular