Clinical trials: Myocardial Function
Myocardial Ischemia, Myocardial Infarction
Magnetic Resonance Technique in the Assessment of Exercise-induced Long- and Short-Term Changes in Cardiac Function and Morphology
Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity.
- Conditions
- Myocardial Ischemia, Myocardial Infarction, Ventricular Remodeling, Myocardial Contraction
- Trial name
- NCT01305304
- Testing
- repeated long term endurance exercise, Other
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Heart Disease, Healthy Control
Periodization of Exercise Training in Patients With Coronary Heart Disease.
The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and…
- Trial name
- PERIOD (NCT03443193)
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Coronary Heart Disease, Diastolic Dysfunction
Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Disease
Based on accumulating evidence showing that impaired cardiac energetic metabolism plays important role in the mechanism of cardiac diastolic dysfunction,the study is designed to evaluate whether metabolic modulator treatment with…
- Trial name
- NCT03887013
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 226 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stable Angina
Comparison of the Vasomotor Function and Myocardial Flow in Patients Treated With Bioresorbable and Metallic Stents at 1 Year
Background: A total of 25-50% of patients with stable coronary atherosclerosis treated with metallic stent implantation remain with effort angina despite optimal medical treatment and absence of stent restenosis at 1 year.
- Trial name
- BVS-Flow (NCT02738658)
- Testing
- Bioresorbable vascular scaffold, Everolimus-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Chronic Kidney Diseases
Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?
This study aims at evaluating, in chronic kidney disease patients on dialysis, the effect of acute per- or pre-dialytic physical exercise on regional myocardial function and myocardial stunning, blood viscosity, arterial…
- Trial name
- EXP DIAL (NCT04831021)
- Testing
- Dialysis without physical exercise, Dialysis with pre-dialytic physical exercise, Dialysis with per-dialytic physical exercise
- Where
- 2 sites in France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Montpellier
Hemodialysis
Intradialytic Exercise and Remote Ischaemic Preconditioning: a Cardioprotective Role ?
The aim of this clinical trial is to evaluate whether intermittent exercise and remote ischaemic preconditioning (rIPC) during haemodialysis (HD) can provide cardioprotection in adult patients (aged 20-79 years) undergoing HD for…
- Trial name
- EXPI-DIAL (NCT06856512)
- Testing
- Remote ischaemic preconditioning, Exercise, standard dialysis
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Avignon
Functional Mitral Regurgitation
Dapagliflozin Effect on FunctiOnal Mitral Regurgitation and Myocardial Remodeling
Functional mitral regurgitation (FMR) leads to various adverse outcomes. Cardiac remodeling (CR) and myocardial fibrosis (MF) are closely related to FMR, forming a vicious circle of CR-FMR-MF and resulting in the end-stage heart…
- Trial name
- DEFORM (NCT05606718)
- Testing
- Dapagliflozin, guideline-directed medical therapy (GDMT)
- Where
- 3 sites in China
- Volunteers
- 98 people
- Sponsor
- Sun Yat-sen University
Type 2 Diabetes
The Impact of Free Fatty Acid (FFA-) Suppression on Myocardial Lipids and Function in Patients With Type 2 Diabetes
There is evidence that inhibition of FFA-release by acipimox is associated with a significant decrease in myocardial lipid content (MYCL) as well as the ejection fraction (as a marker of systolic left ventricular function) in…
- Trial name
- HYPOTESIS (NCT01980524)
- Testing
- acipimox
- Where
- Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Tai Chi Exercises on Physical Activity and Pulmonary Function in CABG
To improve the cardiopulmonary endurance in Coronary artery bypass grafting (CABG) patients. Internationally in cardiac hospital facility of cardiac rehabilitation is available to improve the patient's physical activity and…
- Trial name
- NCT03857282
- Testing
- Aerobic Exercises, Tai Chi Exercises
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Type 2 Diabetes, Diabetic Cardiomyopathies
IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)
The purpose of this study is to assess the activity of IMB-1018972 on cardiac energetic reserve at rest and during stress and to assess safety and tolerability
- Conditions
- Type 2 Diabetes, Diabetic Cardiomyopathies, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT04826159
- Testing
- IMB-1018972
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- Imbria Pharmaceuticals, Inc.
Coronary Artery Disease
Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective…
- Trial name
- HERCET (NCT00457379)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Diabetes Mellitus, Coronary Disease
Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel
In recent years numerous studies have shown that the response of patients to the anti-platelet drug clopidogrel is widely variable.
- Trial name
- MATTIS-D (NCT01643031)
- Testing
- Ticagrelor, Continued clopidogrel
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Rabin Medical Center
Tetralogy of Fallot
Analysis of RV-Dysfunction in Fallot Patients
In the presented study TDI will be used as a modern technique to characterize RV-function in Fallot patients at rest and during different exercise conditions.
- Trial name
- Fallot (NCT03835494)
- Testing
- Transthoracic echocardiography at rest, during PLR, HG and CPX (including blood gas analysis in both groups). Additionally Fallot patients will undergo routine blood testings.
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Acute Myocardial Infarction, Coronary Artery Disease
Acute Coronary Syndrome and Nurse Counselling
The goal of this clinical trial is to examine in patients with acute coronary syndrome. The main questions it aims to answer are: Does nurse counseling affect quality of life? Does nurse counseling affect functional capacity?…
- Trial name
- NCT06034054
- Testing
- nursing counceling
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Iskenderun State Hospital
Myocardial Ischemia
Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting
The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced.
- Trial name
- IMPROVE-CABG (NCT01834846)
- Testing
- no-touch, conventional
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease, Coronary Arteriosclerosis
Effect of a Cardiac Rehabilitation (CR) Programme on Molecular Mechanisms
This study will evaluate the effect of a cardiac rehabilitation (CR) programme on blood protein molecules that may improve the function of arteries in coronary artery disease (CAD) patients who have suffered a heart attack.
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT03907293
- Testing
- Exercise-based cardiac rehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Ulster
Stable Angina, Unstable Angina
Impact of Low Frame Rate Fluoroscopy and Cine-angiography on Reducing Operator and Patient Dose
The investigators sought to investigate the efficacy of low frame rate (fluoroscopy at 7.5 frames per second (FPS) and Cine at 10 pulse per second (PPS) vs.
- Conditions
- Stable Angina, Unstable Angina, Acute Coronary Syndrome
- Trial name
- NCT02574949
- Testing
- Radiation: 15 FPS Cine 15 PPS, Radiation: 7.5 low Frame rate, Low Cine
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University Health Network, Toronto
Myocardial Viability in Ischemic Left Ventricular Dysfunction, Prediction for Improvement in Cardiac Function After Revascularization Therapy
The Use of Myocardial Deformation Imaging
Myocardial deformation imaging allows analysis of myocardial viability in ischemic left ventricular dysfunction. This study will evaluate the predictive value of myocardial deformation imaging for improvement in cardiac function…
- Trial name
- NCT00476320
- Testing
- Magnetic Resonance Imaging, Revascularization, Echocardiography with myocardial deformation imaging
- Where
- Germany
- Sponsor
- RWTH Aachen University
Coronary Artery Disease
Prasugrel With Lower Dose - Loading Dose
Although prasugrel, recently available thienopyridine derivative, exhibits rapid and potent platelet inhibition, concerns of low on-treatment platelet reactivity have been suggested especially in East Asian ethnicities.
- Trial name
- PRELOAD-LD (NCT02070159)
- Testing
- Clopidogrel 600 mg, Prasugrel 30 mg, Prasugrel 60 mg
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Dong-A University
Type 2 Diabetes Mellitus, Overweight
Effects of Low Versus High Carbohydrate Diet During Rehabilitation on Cardiovascular Function and Metabolism in Type 2 Diabetes
Compared to the traditional low fat diet for overweight patients with type 2 diabetes, recent evidence shows that low carbohydrate/high protein diets lower triglycerides and postprandial glucose levels more effectively.
- Trial name
- NCT01004757
- Testing
- LOGI diet, Low Fat diet
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Munich Municipal Hospital