Clinical trials: Myocardial Insulin Sensitivity
Myocardial Insulin Sensitivity, Impaired Glucose Metabolism
Ciprofibrate and Pre-diabetes
Free fatty acids (FFA) are the main fuel source in a healthy adult heart, since they are responsible for 70-80% of the myocardial ATP production.
- Conditions
- Myocardial Insulin Sensitivity, Impaired Glucose Metabolism, Diastolic Dysfunction
- Trial name
- FIT (NCT03662984)
- Testing
- Ciprofibrate 100Mg Tablet
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
Impact of Coronary Artery Bypass Graft (CABG) Surgery on Skeletal Muscle Mass and Insulin Sensitivity, Followed by Exercise Intervention
In this study, the investigators want to examine the impact of coronary artery bypass graft (CABG) surgery on skeletal muscle mass, muscle metabolism, and insulin sensitivity in 90 subjects.
- Trial name
- NCT01333839
- Testing
- exercise training
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Metabolic Syndrome, Lipotoxicity
Regression of Fatty Heart by Valsartan Therapy
Traditionally, obesity is considered an indirect cause of heart disease. Obese individuals typically present with a number of traditional Framingham risk factors (hypertension, dyslipidemia, and type 2 diabetes), predisposing…
- Trial name
- NCT00745953
- Testing
- Valsartan, Hydrochlorothiazide
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Type2 Diabetes Mellitus, Stable Coronary Artery Disease
Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity
A Phase III, single-centre, randomized, 2-arm, parallel-group, double blind, placebo-controlled study, consisting of a screening phase (Days -14 to -1), a 4-week double-blind, placebo-controlled treatment phase and a 4-week…
- Trial name
- DapaHeart (NCT03313752)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Giaccari Andrea
Insulin Sensitivity, Type 2 Diabetes
Effects of Rosiglitazone and Metformin on Metabolism in Type 2 Diabetes
The objectives of this study are to compare the effects of rosiglitazone and metformin on insulin stimulated glucose uptake in subjects with type 2 diabetes.
- Trial name
- ROSI (NCT02526615)
- Testing
- Rosiglitazone, Metformin
- Where
- 3 sites in Finland
- Volunteers
- 48 people
- Sponsor
- Turku University Hospital
Heart Failure, Congestive
Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure
The purpose of this study is to determine whether 48 hours of glucagon-like-peptide-1 (GLP-1) infusion can improve heart function and alter substrate metabolism in non-diabetic patients with heart failure.
- Trial name
- NCT00264199
- Testing
- GLP-1
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital Skejby
Coronary Artery Disease, Postprandial Hyperglycemia
Vitamin D Supplementation in CAD and Postchallenge Hyperglycemia
The main aim of the investigation is to clarify, whether vitamin D supplementation in coronary artery disease patients with vitamin D deficiency and postchallenge hyperglycemia has an impact on endothelial dysfunction and…
- Conditions
- Coronary Artery Disease, Postprandial Hyperglycemia, Vitamin D Deficiency
- Trial name
- NCT01183442
- Testing
- vitamin D
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Graz
Coronary Artery Disease, Glucose Intolerance
Exercise Training, Insulin Resistance and Coronary Artery Disease
The purpose of this study was to determine the effects of exercise training on insulin resistance in subjects with coronary artery disease independent of changes in weight, diet, or the effect of an acute bout of exercise.
- Trial name
- NCT00412815
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Myocardial Infarction
Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction
Stress hyperglycemia during myocardial infarction (MI) is related to mortality at short and long term. Recent studies, however, revealed that chronic statin treatment may decrease both insulin sensitivity and secretion…
- Trial name
- NCT01205347
- Testing
- Simvastatin 80mg, Simvastatin 10mg
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Brasilia Heart Study Group
Diabetes Mellitus, Hypertension
Impact of INsulin Sensitivity on Cardiovascular Risk Markers During 10-20 Years of FOllow up
The purpose of this study is to identify risk factors for insulin resistance and to investigate the influence of insulin sensitivity on development of cardiovascular risk markers like blood pressure, heart rate, body build…
- Conditions
- Diabetes Mellitus, Hypertension, Ischemic Heart Disease, Stroke
- Trial name
- INFO (NCT01412554)
- Where
- Norway
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital