Clinical trials: Myocardial Perfusion
Coronary Disease, Percutaneous Coronary Intervention
Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women
A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).
- Conditions
- Coronary Disease, Percutaneous Coronary Intervention, Exercise Test, Myocardial Perfusion Imaging
- Trial name
- FiRST (NCT04599192)
- Testing
- No study intervention
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Yale University
Myocardial Diseases, Perfusion Imaging
Validation of Myocardial Perfusion and Extracellular Volume Assessment Using Photon-Counting Computed Tomography (PCCT) Compared With Cardiac Magnetic Resonance (CMR) in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI)
Cardiovascular diseases are the leading cause of death worldwide, responsible for about 30% of all deaths. This substantial burden highlights the need for accurate diagnostic tools that help doctors detect heart disease early and…
- Conditions
- Myocardial Diseases, Perfusion Imaging, Stress Perfusion, Myocardial Fibrosis
- Trial name
- NCT07799363
- Testing
- Stress myocardial perfusion imaging with PCCT. Extracellular volume quantification with PCCT.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Myocardial Perfusion Imaging, Diagnostic Certainty
Comparative Imaging of XTR004 PET and MIBI SPECT in Borderline Coronary Stenosis
Compare the diagnostic certainty of MIBI SPECT myocardial perfusion imaging (MPI) and XTR004 PET MPI.
- Conditions
- Myocardial Perfusion Imaging, Diagnostic Certainty, Stable Coronary Artery Disease
- Trial name
- NCT07187895
- Testing
- XTR004
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Sinotau Pharmaceutical Group
Coronary Artery Disease, Myocardial Perfusion Abnormalities
Regadenoson R-T Perfusion Imaging Trial
To exam the feasibility and accuracy of Regadenoson real time perfusion (RTPE) Imaging during vasodilator stress with Regadenoson for detection of significant coronary artery disease (CAD) in patients scheduled to undergo…
- Trial name
- NCT00837369
- Testing
- Regadenoson
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Nebraska
Myocardial Perfusion Imaging, Magnetic Resonance Imaging
Dotarem Evaluation for Myocardial Perfusion CMR
The overall goal of this study is to investigate the signal intensity and relaxation rate characteristics of gadoterate meglumine (Dotarem, Guerbet, USA) enhanced myocardium during rest and stress perfusion cardiovascular…
- Trial name
- NCT03937921
- Testing
- Gadavist 15Ml Solution for Injection
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Coronary Artery Disease, Myocardial Perfusion Abnormalities
Regadenoson Real Time Perfusion Imaging Trial-Optison
The purpose if this study is to examine how effective Regadenoson is in detecting coronary artery disease during a stress echocardiogram when Optison is administered.
- Trial name
- NCT01489176
- Testing
- Regadenoson; Optison
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska
Coronary Occlusion, Myocardial Ischemia
The Influence of Coronary Chronic Total Occlusion on Myocardial Perfusion on Computed Tomography
The COPACABANA study is designed as a single-centre, open, prospective trial aimed to assess the influence of coronary chronic total occlusion (CTO) on downstream myocardial ischemia via the novel computed tomography perfusion…
- Conditions
- Coronary Occlusion, Myocardial Ischemia, Myocardial Perfusion Imaging, Percutaneous Coronary Intervention
- Trial name
- COPACABANA (NCT04465526)
- Testing
- computed tomography perfusion imaging
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Rest Gated Myocardial Perfusion Imaging in Heart Failure
18F-MFBG Cardiac Imaging for Heart Failure Administration
The clinical feasibility of 18F-FMBG cardiac PET imaging will be observed in sympathetic nervous system activity in patients with heart failure, predicted cardiac events, guided ICD implantation, and evaluated therapy efficiency.
- Trial name
- NCT06149195
- Testing
- Standard medical care for heart failure
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Myocardial Perfusion
Study " COFLORES "
Myocardial perfusion is a major parameter characterizing the status of capillary circulation of the myocardium. Its quantification is possible using Magnetic Resonance Imaging (MRI) during the 1st pass of a contrast agent through…
- Trial name
- NCT02848703
- Testing
- Magnetic Resonance Imaging (MRI), phosphorus-31 Magnetic Resonance Spectroscopy, sodium-23 MRI
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Microcirculatory Perfusion, ST Elevation Myocardial Infarction
Deferred or Immediate Stent Implantation Based on Microvascular Function in STEMI
Timely percutaneous coronary intervention (PCI) with stenting implantation is the current standard treatment for patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- SALVAGE (NCT03581513)
- Testing
- Deferred or Immediate Stent Implantation
- Where
- 8 sites in China
- Volunteers
- 629 people
- Sponsor
- Harbin Medical University
Caridac Output-guided Goal-directed Hemodynamic Therapy, Oxygen Delivery
The Effect of Perioperative Cardiac Output-guided GDT on Oxygen Delivery, Consumption, and Microcirculatory Perfusion
Perioperative cardiac output-guided goal-directed therapy (GDT) triggers fluid, vasopressor, and inotrope administration assuming that optimizing cardiac output (i.e., global blood flow) ensures adequate oxygen delivery and…
- Conditions
- Caridac Output-guided Goal-directed Hemodynamic Therapy, Oxygen Delivery, Oxygen Consumption, Microcirculatory Perfusion
- Trial name
- CUSTOM (NCT05090254)
- Testing
- Treatment algorithms targeting cardiac output
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Artery Disease, Myocardial Perfusion
E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion
E-cigarettes deliver nicotine by creating an aerosol of ultrafine particles. Many questions remain about the size and composition and especially about the potential toxicity of these particles.
- Trial name
- NCT02612701
- Testing
- Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Diabetes Mellitus Type 2, Diastolic Dysfunction
Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients
The purpose of this study is to determine whether liraglutide a GLP-1 analogue are effective in the treatment of diastolic dysfunction in type 2 diabetes patients analyzed by cardiac MRI.
- Conditions
- Diabetes Mellitus Type 2, Diastolic Dysfunction, Cardiac MRI, Myocardial Perfusion
- Trial name
- NCT02655770
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Perfusion
Assessment of Myocardial Perfusion by Tomography and Scintigraphy in Patients With Cardiac Stress Test With Ischemia
Cardiovascular diseases are important cause of death, and of these have highlighted the Coronary Artery Disease (CAD) and its various clinical manifestations.
- Trial name
- Perfusão (NCT02810106)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Perfusion Imaging
Real-Time Myocardial Perfusion Echocardiography in the ICU
This study is being done to find out if and how much the use of RTMPE improves a provider's confidence in the diagnosis they assign.
- Trial name
- NCT03173716
- Testing
- Definity
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Other Postprocedural Cardiac Functional Disturbances, Myocardial Perfusion
Dynamic Effects of Online HDF on Cardiac Function and Myocardial Perfusion Utilising Cardiac MRI (CAMRID)
The purpose of this study is to characterise, in detail, the cardiac structure, function and perfusion of those on haemodialysis and haemodiafiltration, comparing the two modalities to ascertain if haemodiafiltration provides…
- Trial name
- CAMRID (NCT02494843)
- Testing
- online Hemodiafiltration, Hemodialysis
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Myocardial Perfusion Imaging, Computed Tomography
Utility of Regadenoson Low-dose Dynamic Computed Tomography for Myocardial Perfusion Assesment (ULYSSES Study).
The ULYSSES study is a single-center, prospective study aimed at evaluation of myocardial ischemia using regadenoson low-dose dynamic computed tomography myocardial perfusion imaging (CTP) in patients diagnosed with intermediate…
- Conditions
- Myocardial Perfusion Imaging, Computed Tomography, Coronary Artery Disease
- Trial name
- ULYSSES (NCT03917199)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Myocardial Perfusion Imaging, Liver Failure
Myocardial Perfusion Imaging in Liver Transplantation Candidates
The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear.
- Trial name
- ExSPECT (NCT03864497)
- Testing
- Myocardial perfusion imaging
- Volunteers
- 403 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Myocardial Perfusion Imaging
Regadenoson vs Dipyridamole in Use as Pharmacological Stress Agent Before SPECT
Myocardial perfusion scintigraphy is to evaluate coronary perfusion as well as heart muscle function. This examination takes place in two stages, one imaging at rest and one after a cardiac stress caused.
- Trial name
- REDUCE (NCT03084562)
- Testing
- collect examination time, functional and clinical tolerability
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Coronary Disease, Echocardiography
Meta-Analysis of Stress Myocardial Perfusion Imaging
Background: Detection of coronary artery disease (CAD) is important due to its high prevalence and its medical and economic implications.
- Conditions
- Coronary Disease, Echocardiography, Fractional Flow Reserve, Myocardial, Hemodynamics
- Trial name
- NCT03180060
- Where
- Mexico
- Volunteers
- 23,051 people
- Sponsor
- American British Cowdray Medical Center