Clinical trials: Myocardial Perfusion Imaging
Diagnostic Imaging, Myocardial Ischemia
Sonazoid in Myocardial Perfusion Imaging
Currently, Sonazoid is mainly used for imaging liver lesions by assessing perfusion characteristics. However, the ultrasound technology is the same as for cardiac imaging and the stability of the microbubbles will potentially aid…
- Trial name
- (SIMPI) (NCT05637333)
- Testing
- Contrast Stress Echocardiography
- Where
- United Kingdom
- Sponsor
- London North West Healthcare NHS Trust
Coronary Artery Disease
Gadobutrol / Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)
Subjects being evaluated for suspected or known Coronary artery Disease (CAD) based on signs and/or symptoms, will be invited to participate in the study.
- Trial name
- GadaCAD 2 (NCT01890434)
- Testing
- Gadobutrol (Gadavist, Gadovist, BAY86-4875)
- Where
- 24 sites in United States, Australia and 2 more
- Volunteers
- 478 people
- Sponsor
- Bayer
Perfusion Imaging, MRI
MRI Perfusion Imaging at 3Tx Compared to Invasive FFR Measurements
Coronary artery disease (CAD) has a great significance concerning prevalence and mortality in the western world. It is usually diagnosed by catheterization and coronary arteries are visually assessed by the examiner.
- Conditions
- Perfusion Imaging, MRI, Myocardial Fractional Flow Reserve, Myocardial Ischemia
- Trial name
- Vision MRT (NCT01277055)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heart Center Bogenhausen
Healthy Volunteer, Coronary Arterial Disease
Ultralow Dose PET Imaging of 18F-flurpiridaz
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET) imaging technique for known or suspected coronary artery disease (for detecting myocardial ischemia or infarction)…
- Conditions
- Healthy Volunteer, Coronary Arterial Disease, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT07284576
- Testing
- 18F-flurpiridaz
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Coronary Artery Disease
Stress CT Perfusion in Patients With Chest Pain
Our hypothesis is that quantitative 3D analysis of cardiac CT images obtained during vasodilator stress can accurately identify patients presenting at the emergency department with acute chest pain due to underlying…
- Trial name
- NCT01969916
- Testing
- Regadenoson
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Coronary Artery Disease (CAD), Myocardial Ischemia
A Study of XTR004 Radiotracer in Healthy Volunteers
XTR004 is a 18F-labeled myocardial perfusion positron emission tomography tracer use to measure myocardial perfusion and myocardial blood flow.
- Trial name
- NCT05195879
- Testing
- XTR004
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Coronary Artery Disease
Comparison of Cardiac Imaging Techniques for Diagnosing Coronary Artery Disease
A large number of cardiac catheterizations are performed each year, primarily to diagnose heart disease. However, a cardiac catheterization is an invasive procedure which is associated with serious complications such as heart…
- Trial name
- PACIFIC (NCT01521468)
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Heart Disease
Optimization of 99mTc-Sestamibi Activities in SPECT/CT Myocardial Perfusion Imaging
This work suggests a methodology to adapt the injected radionuclide activity to the level of attenuation of each patient. The investigators propose a dose reduction adapted to the patient's weight, with no significant degradation…
- Trial name
- OSPECT (NCT05146323)
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Myocardial Infarction (MI)
Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses
Patients with myocardial infarction require invasive treatment involving coronary angiography to confirm the diagnosis and, in most cases, treatment by angioplasty/stenting.
- Trial name
- APRICOT (NCT07112820)
- Testing
- perfusion ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Coronary Artery Disease
Myocardial Stress Perfusion Imaging With Dual Source CT
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan.
- Trial name
- NCT00853671
- Testing
- Adenosine Stress Dual-source CTP
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Increased Right Ventricular Radiotracer Uptake
Stress Induced Right Ventricular Uptake on Lexiscan Stress MPI
The objectives of this study are to determine the: 1. Diagnostic value of stress induced RV changes on Lexiscan stress MPI as compared to Exercise stress MPI in predicting a significant CAD. 2.
- Trial name
- RVuptakeLexi (NCT01697995)
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Aiden Abidov
Patients Being Assessed With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson, Lexiscan
Study With Aminophylline to Attenuate of the Side Effects of Regadenoson
The routine administration of 75 mg of intravenous aminophylline following regadenoson (Lexiscan®), a commonly used medication for nuclear stress testing of the heart, can reduce the gastrointestinal (diarrhea and stomach upset)…
- Trial name
- ASSUAGE (NCT01250496)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Rush University Medical Center
Coronary Artery Disease
Anti-gravity Treadmill Exercise in Stress Myocardial Perfusion Imaging
This study will test the hypothesis that the anti-gravity treadmill can be safely used in stress nuclear myocardial perfusion imaging in patients unable to perform conventional treadmill exercise.
- Trial name
- NCT02628002
- Testing
- Antigravity treadmill (Alter-G), Conventional treadmill/regadenoson
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Cincinnati
Hypertrophic Cardiomyopathy
Perfusion Imaging With Myocardial Contrast Echocardiography in HCM
The objective of this study is to determine whether myocardial contrast echocardiography in patients with cardiomyopathy (HCM) can detect resting hypo-perfusion due to fibrosis or stress induced perfusion defects due to…
- Trial name
- NCT02560467
- Testing
- Echo and myocardial contrast echocardiography perfusion imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Coronary Artery Disease (CAD)
A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT)
The purpose of this study is to demonstrate that the strength of agreement between single photon emission computed tomography (SPECT) imaging with regadenoson following inadequate exercise stress testing and SPECT imaging with…
- Trial name
- EXERRT (NCT01618669)
- Testing
- Regadenoson, Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI)
- Where
- 69 sites in United States, Argentina and 2 more
- Volunteers
- 1,147 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Hypertrophic Cardiomyopathy, Myocardial Perfusion Imaging
Presentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging
Chest pain and myocardial ischemia are prevailing features in patients with hypertrophic cardiomyopathy (HCM). Recently introduced single-photon emission computed tomography (SPECT) cameras with solid-state cadmium-zinc-telluride…
- Trial name
- NCT03150342
- Testing
- myocardial perfusion imaging
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Coronary Artery Disease
Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia
Binodenoson (an experimental drug) and adenosine (an FDA-approved drug that is currently used by doctors) are used to increase blood flow to the heart just like when a person exercises on a treadmill.
- Trial name
- VISION-305 (NCT00944970)
- Testing
- binodenoson, adenosine
- Volunteers
- 578 people
- Sponsor
- Pfizer
Coronary Artery Disease
Direct Comparison of 2D Cardiac PET With 3D Cardiac PET
Lowering the per-infusion dose of Rb-82 offers advantages of lessening radiation exposure and extending useable generator life. Prior studies have not shown equivalence of 3D vs 2D Rb-82 PET.
- Trial name
- NCT01993303
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Cardiovascular Imaging Technologies
Coronary Artery Disease
Quantitative 13N-Ammonia Cardiac Rest/Stress Digital PET/CT
Accurate measurements from a non-invasive test like myocardial perfusion positron emission tomography/ computed tomography (PET/CT) may decrease the need for invasive procedures such as cardiac catheterization.The investigators…
- Trial name
- NCT03170817
- Testing
- Cardiac Perfusion Rest/Stress Digital PET/CT, N-13 ammonia, Regadenoson
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Heart Disease, Ischemic, Atherosclerosis, Coronary
Comprehensive Evaluation of Ischemic Heart Disease Using MRI
The purpose of the study is to assess the diagnostic performance of fully automated motion corrected (MC) first pass myocardial perfusion MRI, compared to the original non-corrected first pass myocardial perfusion images in a…
- Trial name
- NCT01234870
- Testing
- Gadolinium, Adenosine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University