Clinical trials: Myocardial Protection
Congenital Heart Disease, Heart Valve Disease
Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery
Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft.
- Trial name
- NCT01653223
- Testing
- simvastatin
- Where
- China
- Volunteers
- 369 people
- Sponsor
- Sun Yat-sen University
Ischemic Reperfusion Injury
Lipid Emulsion in Cardiac Valve Replacement Surgery
Myocardial protection has become an essential adjunctive measure in cardiac surgery to bail the myocardium out of ischemia/reperfusion-induced damage during the operation.
- Trial name
- NCT04951791
- Testing
- SMOFlipid, Normal saline 0.9%
- Volunteers
- 68 people
- Sponsor
- Assiut University
Pathological Processes, Cardiomyopathies
Adenosine as an Adjunct to Blood Cardioplegia
Myocardial protection is a major issue in cardiac surgery, since inadequate protection increases the risk of postoperative cardiac dysfunction.
- Trial name
- NCT02681913
- Testing
- Adenosine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amphia Hospital
Acute Coronary Syndromes
RADIATION PROTECTion With a Pelvic Lead Shield and a Radiation Protection Cap for Operators Performing Coronary Angiography or Intervention
RADIATION PROTECT is a randomized, controlled trial of patients undergoing coronary angiography or PCI with or without a pelvic lead shield.
- Trial name
- NCT02128035
- Testing
- With Lead Shield
- Where
- Canada
- Volunteers
- 230 people
- Sponsor
- Dr. Sanjit S. Jolly
Anterior Myocardial Infarction, Heart Failure
Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients
The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior…
- Trial name
- NCT03579914
- Testing
- Metoprolol Injectable Product, Romote Ischemic Conditioning (RIC), Metoprolol & RIC
- Where
- 16 sites in China
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Harbin Medical University
Myocardial Infarction
Exenatide for Myocardial Protection During Reperfusion Study
This study aims to assess the effect of exenatide on myocardial injury in patients undergoing emergent percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction or heart attack (STEMI).
- Trial name
- EMPRES (NCT01938235)
- Testing
- Exenatide
- Where
- 10 sites in Canada
- Volunteers
- 198 people
- Sponsor
- University Health Network, Toronto
CHD - Coronary Heart Disease, Angina, Stable
Coronary Microcirculatory and Bioresorbable Vascular Scaffolds
Angina and heart attacks are caused by narrowings in the coronary arteries (blood vessels) supplying the heart. These narrowings can be opened using a balloon and stent (angioplasty).
- Conditions
- CHD - Coronary Heart Disease, Angina, Stable, Myocardial Ischemia
- Trial name
- EMPIRE-BVS (NCT03076476)
- Testing
- Bioresorbable Vascular Scaffolds (BVS), Drug-Eluting Stent (DES) - slow, Drug-Eluting Stent (DES) - standard(std)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Coronary Artery Disease, Myocardial Ischemia
Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent
The purpose of the study is to demonstrate that Custodiol-HTK is not inferior to cold cardioplegic solution in patients undergoing cardiovascular surgery requiring cardioplegic arrest.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- NCT01681095
- Testing
- Custodiol HTK, Cold Blood Cardioplegia
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Marc Sakwa, MD
Myocardial Protection in TOF Repair
Myocardial Protection and Clinical Outcome in Patients Undergoing Tetralogy of Fallot Repair : A Randomized Study of Two Different Cardioplegia Technique
Myocardial protection and clinical outcome in patients Undergoing tetralogy of fallot repair: a randomized study of Two cardioplegic techniques.
- Trial name
- TOF (NCT02646254)
- Testing
- blood cardioplegia, del nido cardioplegia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- SUNDER LAL NEGI
Myocardial Ischemic Reperfusion Injury
Myocardial Protection and Anesthetic Agents
The aim of this study was to investigate the myocardial protective effects of remifentanil and dexmedetomidine in cardiac surgery.
- Trial name
- NCT02405689
- Testing
- Remifentanil, Dexmedetomidine, Sevoflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Cardiopulmonary Bypass
Amobarbital and Cardiopulmonary Bypass
Explore the effects of amobarbital on myocardial protection and prognosis in patients undergoing cardiac surgery with cardiopulmonary bypass, investigate the new usage of old drugs, and provide reliable clinical scientific basis…
- Trial name
- NCT06757868
- Testing
- Amobarbital, Midazolam
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tongji Hospital
Open Mitral Cardiac Surgery
Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment
Can pre-operative left stellate ganglion block offer myocardial protection in on-pump mitral valve replacement? A histopathological and clinical assessment.
- Trial name
- NCT06476925
- Testing
- sonar guided stellate ganglion injection, sonar guided stellate ganglion block
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Minia University
COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle
Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19
Long COVID or Postacute sequelae of COVID-19 infection (PASC) are increasingly recognised complications, defined by lingering symptoms, not present prior to the infection, typically persisting for more than 4 weeks.
- Conditions
- COVID-19 Associated Cardiac Involvement, Remodeling, Left Ventricle, Remodeling, Vascular, Left Ventricular Dysfunction
- Trial name
- MYOFLAME-19 (NCT05619653)
- Testing
- Prednisolone, Losartan
- Where
- 5 sites in Austria, Germany
- Volunteers
- 279 people
- Sponsor
- Valentina Puentmann
Cardiogenic Shock, Acute Decompensated Heart Failure
SURPASS Impella 5.5 Study
A multi-center, prospective \& retrospective, observational single-arm study of the clinical outcomes up to one year collected from electronic health records of patients which have undergone standard of care implantation of…
- Trial name
- NCT05100836
- Testing
- Impella 5.5
- Where
- 15 sites in United States
- Volunteers
- 1,017 people
- Sponsor
- Abiomed Inc.
Left Ventricular Dysfunction
Insulin Cardioplegia for Poor Left Ventricular Function
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular…
- Trial name
- NCT00188994
- Testing
- Insulin Cardioplegia
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Congenital Heart Disease
Remote Preconditioning and Myocardial Protection
Remote ischemic preconditioning (RIPC) of the myocardium by limb ischemia/reperfusion may mitigate cardiac damage, but its interaction with the anesthetic regimen is unknown.
- Trial name
- NCT02877238
- Testing
- Sevoflurane plus remote ischemic preconditioning, Total intravenous anesthesia plus remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- Assiut University
Anesthesia, Cardiac Surgery
Sevoflurane in Cardiac Surgery
Patients undergoing high risk cardiac surgery (combined CABG and valvular procedures) will be randomized to receive a total intravenous anesthesia or an anesthesia plan with sevoflurane.
- Trial name
- SEVO AIFA (NCT00821262)
- Testing
- sevoflurane, propofol
- Where
- 5 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Università Vita-Salute San Raffaele
Coronary Artery Disease
Distal Protection Combined With PTCA in AMI Patients
The primary objective is to evaluate if use of the AngioGuard™ XP improves myocardial reperfusion after PTCA as assessed by ST segment resolution at the end of PTCA.
- Trial name
- DIPLOMAT (NCT00264030)
- Testing
- Angioguard distal protection device, PTCA
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Cordis US Corp.
Remote Ischemic Preconditioning, Myocardial Protection
Protection of the Heart With Remote Ischemic Preconditioning During Heart Surgery: A Pilot Study
The purpose of this study is to compare a treatment called remote ischemic preconditioning (rIP) to no treatment. rIP is a simple treatment that is believed to help patients recover better after heart surgery.
- Trial name
- NCT00546390
- Testing
- Blood Pressure Cuff
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Alberta