Clinical trials: Myocardial Protection
Coronary Disease, Weight Loss
Time Restricted Feeding for Weight Loss and Cardio-protection
Time restricted feeding (TRF) is a novel form of intermittent fasting that involves confining the period of food intake to 8 h/d (e.g. 10 am to 6 pm) without calorie counting.
- Trial name
- NCT02948517
- Testing
- Time restricted feeding
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Coronary Atherosclerosis, Myocardial Infarction
CANARY: Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow
The CANARY (Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow) Study is a pivotal trial to evaluate criteria for defining a Lipid Core Plaque (LCP) that is at high risk of rupturing during standard of…
- Conditions
- Coronary Atherosclerosis, Myocardial Infarction, Coronary Plaque Embolization
- Trial name
- CANARY (NCT01268319)
- Testing
- Embolic Protection Device (EPD), Intracoronary Spectroscopy and Ultrasonic Evaluation, Angioplasty and Stent Implant
- Where
- 9 sites in United States
- Volunteers
- 85 people
- Sponsor
- Infraredx
Coronary Artery Disease, Heart Valve Diseases
Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery
This prospective randomized study evaluates the nephroprotective effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Coronary Artery Disease, Heart Valve Diseases, Cardiomyopathies, Acute Kidney Injury
- Trial name
- NephroNO (NCT03527381)
- Testing
- Nitric Oxide, Standard CPB
- Volunteers
- 96 people
- Sponsor
- Nikolay Kamenshchikov
Hypertrophic Obstructive Cardiomyopathy
Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy
Perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications.
- Trial name
- NCT05073094
- Testing
- Esmolol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Systemic Inflammatory Response
The Effect of Influenza Vaccination on the Systemic Inflammatory Response and Myocardial Protection in Patients Undergoing Cardiac Surgery: a Randomized Controlled Trial
To assess the impact of influenza vaccination on the overall systemic inflammatory response in patients undergoing cardiac surgery and investigate functional and clinical outcomes in vaccinated patients postoperatively.
- Trial name
- NCT02565277
- Testing
- Influenza Vaccine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Health Sciences North Research Institute
Thoracic Surgery, Cardiopulmonary Bypass
Protection During Cardiac Surgery.
This trial investigates whether a multimodal cardioprotection per-surgery therapeutic strategy could reduce myocardial injury in patients undergoing cardiac surgery compared to traditional management.
- Trial name
- ProCCard (NCT03230136)
- Testing
- multimodal cardioprotection strategy, standard anesthetic procedure
- Where
- 8 sites in France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Bypass Surgery
A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery
To compare two different methods of protecting heart muscle from damage caused by a decreased blood supply. Exposure to the anaesthetic agent sevoflurane can allow the heart muscle to resist longer periods of low blood or oxygen…
- Trial name
- NCT00244283
- Testing
- Sevoflurane, High thoracic epidural analgesia
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Golden Jubilee National Hospital
Heart; Surgery, Heart, Functional Disturbance as Result
Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery
Cardioplegia solutions have been used for myocardial protection in cardiac surgery for decades. Different cardioplegic strategies have been evaluated.
- Trial name
- NCT04094168
- Testing
- DEL NIDO CARDIOPLEGIA, COLD BLOOD BASED CARDIOPLEGIA
- Where
- Spain
- Volunteers
- 474 people
- Sponsor
- JESSICA GARCIA SUAREZ
Reperfusion Injury, Myocardial
Empagliflozin on Cardiac-renal Injury in Patients With STEAMI Patients After Primary PCI
This study is a single-center, prospective controlled trial addressing effectiveness of empagliflozin on cardiac-renal injury in patients with STEMI.
- Trial name
- NCT03591991
- Testing
- Empagliflozin
- Volunteers
- 128 people
- Sponsor
- Chinese PLA General Hospital
Septic Cardiomyopathy, Septic Shock
The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis
This study focuses on improving heart function in patients with life-threatening blood infections (septic shock). When the body fights severe infections, the heart sometimes struggles to pump blood effectively, which can lead to…
- Trial name
- SHIELD Trail (NCT06898723)
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 440 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Anesthesia
Comparison Between Histidine-tryptophan-ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection for Fallot Tetralogy Patients Undergoing Total Repair
Randomized clinical trial: comparison between Histidine-tryptophan-ketoglutarate cardioplegia and cold blood cardioplegia for myocardial protection for Fallot tetralogy patients undergoing total repair This study aims to compare…
- Trial name
- NCT05176782
- Testing
- HTK cardioplegia, Cold Cadioplegia
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2, Cardiovascular Diseases
The Cardio-Metabolic Clinic
This study aims to investigate whether a Cardio-Metabolic Clinic can protect the cardiovascular health of patients with both diabetes and cardiovascular disease.
- Trial name
- ProtecT-2-D (NCT06203860)
- Testing
- Cardio-Metabolic Clinic
- Where
- Denmark
- Volunteers
- 1,600 people
- Sponsor
- Odense University Hospital
Coronary Heart Disease
Application of a New X-ray Protective Device in Coronary Interventional Therapy
This is a multi-center, prospective and controlled clinical trial which will enroll 200 coronary arteriography or percutaneous coronary intervention with 2-4 interventional cardiologist.
- Trial name
- NCT05088291
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Myocardial Protection
Levosimendan and Myocardial Protection
The aim of this study is to investigate whether pharmacological pre-treatment with levosimendan reduces intensive care unit (ICU) length of stay in patients undergoing elective myocardial revascularization under cardiopulmonary…
- Trial name
- NCT00610350
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Cardiac Surgical Procedures, Heart Valve Prosthesis Implantation
Myocardial Protection With Phosphocreatine in High-RIsk Cardiac SurgEry Patients
There is evidence on the role of the phosphotransfer system in the energy metabolism of the heart, with altered energetics playing an important role in the mechanisms of heart failure.
- Trial name
- PRISE (NCT02757443)
- Testing
- Phosphocreatine sodium tetrahydrate after anaesthesia induction, 5% Glucose after anaesthesia induction, Phosphocreatine sodium tetrahydrate added to cardioplegia
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI
STRATUS-PCI is a pilot clinical trial that compares two ways of running a small heart pump called Impella CP during a high-risk procedure to open blocked heart arteries (percutaneous coronary intervention, or PCI) in patients…
- Trial name
- STRATUS-PCI (NCT07588399)
- Testing
- Impella CP
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Rayyan Hemetsberger
Coronary Artery Disease, Coronary Disease
Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)
Background: CCTA is a common way to evaluate coronary artery disease. It stands for coronary computed tomography angiography. It uses scanning to look at the arteries that supply blood to the heart.
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- NCT03253692
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Disease, Shock, Cardiogenic
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery
Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects…
- Conditions
- Coronary Disease, Shock, Cardiogenic, Renal Failure, Stroke
- Trial name
- GLORIOUS (NCT02673931)
- Testing
- Byetta (Lilly, Exenatide), Conoxia (AGA, oxygen), 20% Human Albumin
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Ischemia
Cardiovascular Disease Protection Tissue
Recent evidence of a potential role for cardiac progenitor cells (CPCs) in cardiac repair and the discovery of a vasoprotective axis of the renin-angiotensin system (RAS) offer such breakthroughs.
- Trial name
- NCT02348515
- Testing
- Heart failure or coronary disease, Heart transplant patients, Orthotopic Heart Transplant Patients
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Saphenous Vein Graft Disease, Myocardial Ischemia
The RETRIEVE Study: Use of the FiberNet® Embolic Protection System in Saphenous Vein Grafts
This is a multicenter, prospective study designed to demonstrate the performance and safety of the FiberNet Embolic Protection System when used as an adjunctive device during saphenous vein graft (SVG) intervention.
- Conditions
- Saphenous Vein Graft Disease, Myocardial Ischemia, Embolism
- Trial name
- RETRIEVE (NCT00453518)
- Testing
- FiberNet EPS used during SVG intervention.
- Where
- 6 sites in United States
- Volunteers
- 29 people
- Sponsor
- Lumen Biomedical