Clinical trials: Myocardial Strain
Cardiac Structure and Function, Intracardiac Hemodynamic
Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders
The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions.
- Trial name
- IHMS (NCT06075342)
- Testing
- exercise
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Chest Trauma
Acute Myocardial Dysfunction and Chest Trauma - The Strainy Trauma Study
This study aims to investigate whether the identification of acute myocardial dysfunction by 2D-strain transthoracic sonography in the first week following trauma would allow to better diagnose occult and severe patterns of…
- Trial name
- Strainy trauma (NCT04748003)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Athlete Heart
Myocardial Mechanics in Athlete's Heart
Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling.
- Trial name
- NCT05543525
- Testing
- Echocardiography, Cardiopulmonary exercise testing
- Where
- France
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Non-ST Elevation Myocardial Infarction (NSTEMI), Acute Coronary Syndrome
Left Atrial Strain for Predicting MACE in NSTEMI
This prospective observational study aims to evaluate whether left atrial reservoir strain, measured by two-dimensional speckle tracking echocardiography, independently predicts 6-month major adverse cardiovascular events (MACE)…
- Conditions
- Non-ST Elevation Myocardial Infarction (NSTEMI), Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- NCT07797634
- Volunteers
- 150 people
- Sponsor
- Assiut University
Myocardial Dysfunction, Liver Transplant; Complications
Strain Analysis for Assessment of Myocardic Dysfunction During Orthotopic Liver Transplantation
Mycocardial systolic function (contractility) is an essential element of cardio-circulatory physiology during major visceral surgery, in particular during liver transplantation during which several factors are likely to be at the…
- Trial name
- STRAIN ETO (NCT05037838)
- Testing
- Longitudinal strain obtained thanks to transesophageal ultrasound data recorded during liver transplantation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure
Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This study will compare two ultrasound techniques, 2D and 3D speckle-tracking echocardiography, for measuring how well the heart muscle contracts in patients with heart failure and reduced pumping function.
- Trial name
- 3V2-STEM-HF (NCT07741305)
- Where
- 5 sites in Italy
- Volunteers
- 419 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Congestive Heart Failure Acute
The Effect of Dapagliflozin on Myocardial Strain in Patients With Acute Heart Failure
The goal of this clinical trial is to assess the impact of dapagliflozin on myocardial strain in patients with acute heart failure using speckle tracking echocardiography (STE).
- Trial name
- NCT07403955
- Testing
- Dapagliflozin 10mg Tab
- Volunteers
- 188 people
- Sponsor
- Qilu Hospital of Shandong University
Atrial Function
Normal Values for Myocardial Left Atrial Strain
Transversal retrospective and unicentric study. The investigators sought to determine the normal values for two-dimensional myocardial left atrial strain for the cardiology ultrasound system available in their centre (Philips…
- Trial name
- NCT03874624
- Testing
- two-dimensional speckle tracking
- Where
- Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Leukemia, Cardiac Toxicity
Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain
It is now accepted that the anticancer properties of anthracyclines were allowed in many malignancies improve the prognosis of affected populations.
- Trial name
- CA2D (NCT01212926)
- Testing
- Echographic analysis of myocardial deformation in 2D strain
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
if Aortic Stiffness, Myocardial Wall Strain
RITHM - Resonance Imaging Trial for Heart Biomarkers in Adolescent/Young (AYA) Cancer Survivors
Cardiovascular events are the leading non-cancer cause of mortality after childhood cancer, occurring at a significantly younger age than in the general population.
- Trial name
- NCT01719094
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Myocardial Infarction, STEMI
Intramyocardial Haemorrhage in Patients With Primary STEMI
The purpose of the study is to assess the frequency and intensity of intramyocardial haemorrhage in patients with primary STEMI and different reperfusion strategies.
- Conditions
- Myocardial Infarction, STEMI, Myocardial Necrosis, Myocardial Injury
- Trial name
- HaemInCor (NCT03677466)
- Testing
- Pharmaco-invasive strategy, Primary PCI
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
ST Elevation (STEMI) Myocardial Infarction
LA Strain in Predicting Early Complication in STEMI After PPCI
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI.
- Trial name
- NCT07263282
- Testing
- 2D echocardiography
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiomyopathies
Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients
The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown.
- Trial name
- COCARDE (NCT04358952)
- Testing
- Global Longitudinal Strain
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Toulouse
HER2 Positive Breast Cancer, Cardiovascular Abnormalities
A Prospective Study of Breast Cancer Patients With Abnormal Strain Imaging
The Cardio-Oncology program at Northwestern offers care to cancer patients who develop cardiac toxicities from chemotherapy. Breast cancer patients with the tumor marker for HER2 necessitate treatment with anthracycline and/or…
- Trial name
- NCT02993198
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Northwestern University
Heart Failure
Deep Learning-Based Automated Pressure-Strain Loop Analysis
Noninvasive left ventricular pressure-strain loop analysis estimates myocardial work from longitudinal strain, brachial systolic blood pressure, and cardiac valve-event timing.
- Trial name
- NCT07850726
- Testing
- Sustained Isometric Handgrip Exercise, Semi-Supine Bicycle Exercise
- Where
- Norway
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Valvular Heart Disease Stenosis and Regurgitation
Different Methods of Cardiac MRI in Assessment of Estimated Corrected Ejection Fraction in Valvular Heart Diseases
Comparative study between Phase Contrast , Modified Simpson Rule and Myocardial Strain Analysis methods of Cardiac Magnetic Resonance Imaging in assessment of Corrected Estimated Ejection Fraction in Valvular Heart Disease To…
- Trial name
- NCT05808465
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Disease, Anesthesia
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
- Trial name
- Promise-O2 (NCT04808401)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases, Ischaemic Heart Disease
Machine Learning in Quantitative Stress Echocardiography
Greater diagnostic accuracy is required to find out who is at risk of a heart attack as this can reduce the requirement of more invasive downstream tests and thereby improve the patient experience and also reduce their exposure…
- Trial name
- MLQSE (NCT04193475)
- Testing
- Analysis
- Where
- United Kingdom
- Volunteers
- 1,250 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Coronary Artery Disease
Strain-Encoded Cardiac Magnetic Resonance Imaging for Dobutamine Stress Testing
The purpose of this study is to compare the diagnostic value of SENC to that provided by conventional wall motion analysis for the detection of inducible ischemia during DS-MRI.High-dose dobutamine stress magnetic resonance…
- Trial name
- NCT00758654
- Where
- Germany
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Heidelberg University