Clinical trials: Myocarditis
Myocarditis Acute
Pulse Corticosteroids Or/and Immunoglobulins to Treat Fulminant Myocarditis
Fulminant myocarditis (FM) is the most severe manifestation of acute myocarditis, an acute inflammatory myocardial disease most often triggered by viral infections.
- Trial name
- CORIUM (NCT06896253)
- Testing
- Pulse bolus corticosteroids, Pulse bolus corticosteroids and IVIG, Pulse bolus corticosteroids (G5%) and IVIG (G5 %)
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocarditis, Pediatric Inflammatory Multisystem Syndrome
Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
- Conditions
- Myocarditis, Pediatric Inflammatory Multisystem Syndrome, Kawasaki Disease
- Trial name
- NCT05911386
- Testing
- study of biological samples and echocardiographic data and link with need of hemodynamic support
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Immune Checkpoint Inhibitors Related Myocarditis
ICIAM Rehabilitation Program Study: A Randomized Controlled Trial
Immunotherapy has become a cornerstone in oncology; however, managing its associated adverse events poses a significant clinical challenge.
- Trial name
- NCT07280429
- Testing
- rehabilitation protocol
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Prevalence of Myocarditis in MINOCA Patients
Prevalence of Myocarditis in Patients Suspected Myocardial Infarction With Non-Obstructive Coronary Arteries
This study aims to determine the prevalence of myocarditis among patients suspected of having myocardial infarction with non-obstructive coronary arteries (MINOCA) and to analyze its clinical characteristics, diagnostic markers .
- Trial name
- NCT06966531
- Testing
- Coronary angiography
- Volunteers
- 148 people
- Sponsor
- Assiut University
Post Viral Fatigue, Viral Myocarditis
Post-COVID-19 Outpatient Care and Biomarkers
The aims of this case-control, non-randomized study including patients with post-COVID-19 persisting symptoms are 1) to establish the large blood biobank, 2) to examine levels of circulating inflammatory biomarkers and different…
- Conditions
- Post Viral Fatigue, Viral Myocarditis, POTS
- Trial name
- POSTCOV (NCT05398952)
- Testing
- Laboratory investigations
- Where
- Austria
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Myocarditis
Myocarditis Registry for Children and Adolescents - MYKKE
MYKKE is a prospective multi-center registry for children and adolescents with myocarditis. The aim is to generate prospective multi-center data on epidemiology, diagnostics, and therapy of pediatric patients with myocarditis in…
- Trial name
- MYKKE (NCT02590341)
- Where
- 13 sites in Germany
- Volunteers
- 1,500 people
- Sponsor
- German Heart Institute
Myocarditis, Giant Cell Myocarditis
Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis
OBJECTIVES: I. Assess the effect of immunosuppression with muromonab-CD3, cyclosporine, methylprednisolone, and prednisone versus standard care in terms of death, heart transplantation, or left ventricular assistive device…
- Trial name
- NCT00004482
- Testing
- Cyclosporine, methylprednisolone, Muromonab-CD3
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Cardiovascular Diseases, Hypertrophic Cardiomyopathy (HCM)
AI-enabled Screening and Diagnosis of Cardiomyopathies Using Coronary CTA
The goal of this observational and diagnostic study is to develop and validate an artificial intelligence assisted approach for coronary computer tomography angiography-(CCTA)-based screening and diagnosis of cardiomyopathies in…
- Conditions
- Cardiovascular Diseases, Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Restrictive Cardiomyopathy
- Trial name
- Atlantis (NCT06748261)
- Testing
- CCTAI model
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
COVID-19
Cardiac Injury in COVID-19: a Pathology Study
The primary goal of the study is to conduct the first systematic cardiac autopsy study in 60 patients dying from COVID-19 to understand the pathology and pathogenesis of cardiac injury in patients with COVID-19, with/without…
- Trial name
- NCT04367792
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Sarcoidosis With Myocarditis, Sarcoidosis
Cell Free DNA in Cardiac Sarcoidosis
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing…
- Conditions
- Sarcoidosis With Myocarditis, Sarcoidosis, Healthy, ST Elevation Myocardial Infarction
- Trial name
- cfDNA in CS (NCT03858777)
- Testing
- cell free DNA
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nabeel Hamzeh
Myocarditis Acute
One-year Prognostic Impact of Microcirculation Assessed by NH IMR Angio in Patients Hospitalized for Acute Myocarditis
The goal of this observational study is to evaluate the association between post-coronary angiography IMR and medium-term clinical prognosis in patients with acute myocarditis.
- Trial name
- MICROMYOC (NCT07676201)
- Testing
- Coronary catheterization
- Volunteers
- 106 people
- Sponsor
- University Hospital, Grenoble
Viral Myocarditis, Cardio-Renal Syndrome
Risk Factors for Predictors of In-hospital Death in Acute Fulminant Myocarditis
The investigators performed a retrospective, single-center observational study, and the participants with acute fulminant myocarditis were included.Then, the investigator analyzed the risk factors of in-hospital death in these…
- Conditions
- Viral Myocarditis, Cardio-Renal Syndrome, Risk Factor, Cardiovascular
- Trial name
- NCT03219996
- Testing
- prognosis
- Volunteers
- 76 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Myocarditis, Ischemia
The ORCHESTRATE-Myocarditis Registry
A retrospective, observational study consisting of patients who presents with typical/atypical chest pain and have an ensuing negative ischemic evaluation
- Conditions
- Myocarditis, Ischemia, Chest Pain
- Trial name
- NCT05139329
- Testing
- Imaging
- Where
- 4 sites in United States
- Volunteers
- 382 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Lupus
Cardiac Imaging in Systemic Disorders: the ORACLES Registry
Autoimmune diseases affect a total of 5 to 10% of the population. These diseases are associated with an increased risk of developing cardiovascular pathologies.
- Trial name
- ORACLES (NCT07134166)
- Testing
- data collection
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocarditis
Efficacy of a Myocardial Panel in the Management and Treatment of Pediatric Myocarditis
The goal of this observational study is to determine the efficacy a of combined management and treatment driven by the systematic determination of viral genome, bacterial serology, and markers of inflammation in pediatric…
- Trial name
- NCT07086144
- Testing
- Determination of viral genome, bacterial serology, and markers of inflammation in pediatrics diagnosed with myocarditis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Myocarditis
Pathophysiologic Mechanism for MYOcarditis in COVID19 VAccinations ("MYOVAx" Study)
The coronavirus disease 2019 (COVID-19) is an ongoing pandemic which has infected more than 160 million people and caused 3.4 million deaths worldwide till May 2021.
- Trial name
- MYOVAx (NCT05282498)
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National Heart Centre Singapore
Viral Myocarditis
Presentation, Clinical Course and Patterns of Myocardial Damage Due to Viral Myocarditis
Presentation, Clinical Course and Patterns of Myocardial Damage due to Viral Myocarditis
- Trial name
- NCT04527835
- Testing
- ELIZA, Extraction of nucleic acid ,Determination of viral genome by using PCR, Quantitative real-time PCR to assess viral load ,Immunohistochemistry analysis of EMB.
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Assiut University
PVC - Premature Ventricular Contraction, Myocarditis
Role of Novel ILR in the Management of PVCs
This prospective, observational study is a single center clinical registry of patients referred for management of symptomatic or asymptomatic Premature Ventricular Contractions (PVCs). Subjects will be followed through 12 months.
- Trial name
- NCT06060548
- Testing
- Monitoring of patients presenting with PVCs
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Myocarditis
Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis
Infectious myocarditis are frequent, most of the time viral and can evolve to cardiac insufficiency. The diagnosis is difficult because they can mime an acute coronary syndrome.
- Trial name
- DOTAMIR (NCT03347760)
- Testing
- DOTATOC-68Ga PET initial, DOTATOC-68Ga PET at 6 months, blood sample
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Central Hospital, Nancy, France
Myocarditis
Prognostic Role of High Sensitivity Troponin During Follow up in the Evolution of Acute Myocarditis
The goal of this observational study is to observe if ultra-sensitive troponins (us) measurement between 3 and 6 months after the acute event will be sensitive enough to dispense with all other examinations, particularly cardiac…
- Trial name
- PROGNOSTIC (NCT05949450)
- Where
- France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Grenoble